TY  - JOUR
AU  - Tomić, Mirko
AU  - Kundaković, Marija
AU  - Butorović, Biljana
AU  - Petković, Branka
AU  - Andrić, Deana
AU  - Roglić, Goran
AU  - Ignjatović, Đurđica
AU  - Kostić-Rajačić, Slađana
PY  - 2004
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007462?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3805
AB  - Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics (>1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats.
PB  - Pergamon-Elsevier Science Ltd
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
IS  - 16
VL  - 14
DO  - 10.1016/j.bmcl.2004.06.005
SP  - 4263
EP  - 4266
ER  - 

@article{
author = "Tomić, Mirko and Kundaković, Marija and Butorović, Biljana and Petković, Branka and Andrić, Deana and Roglić, Goran and Ignjatović, Đurđica and Kostić-Rajačić, Slađana",
year = "2004",
abstract = "Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics (>1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential",
number = "16",
volume = "14",
doi = "10.1016/j.bmcl.2004.06.005",
pages = "4263-4266"
}

Tomić, M., Kundaković, M., Butorović, B., Petković, B., Andrić, D., Roglić, G., Ignjatović, Đ.,& Kostić-Rajačić, S.. (2004). Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd., 14(16), 4263-4266.
https://doi.org/10.1016/j.bmcl.2004.06.005

Tomić M, Kundaković M, Butorović B, Petković B, Andrić D, Roglić G, Ignjatović Đ, Kostić-Rajačić S. Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters. 2004;14(16):4263-4266.
doi:10.1016/j.bmcl.2004.06.005 .

Tomić, Mirko, Kundaković, Marija, Butorović, Biljana, Petković, Branka, Andrić, Deana, Roglić, Goran, Ignjatović, Đurđica, Kostić-Rajačić, Slađana, "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential" in Bioorganic and Medicinal Chemistry Letters, 14, no. 16 (2004):4263-4266,
https://doi.org/10.1016/j.bmcl.2004.06.005 . .