TY  - JOUR
AU  - Tomić, Mirko
AU  - Kundaković, Marija
AU  - Butorović, Biljana
AU  - Petković, Branka
AU  - Andrić, Deana
AU  - Roglić, Goran
AU  - Ignjatović, Đurđica
AU  - Kostić-Rajačić, Slađana
PY  - 2004
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007462?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3805
AB  - Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics (>1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats.
PB  - Pergamon-Elsevier Science Ltd
T2  - Bioorganic and Medicinal Chemistry Letters
T1  - Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential
IS  - 16
VL  - 14
DO  - 10.1016/j.bmcl.2004.06.005
SP  - 4263
EP  - 4266
ER  - 

@article{
author = "Tomić, Mirko and Kundaković, Marija and Butorović, Biljana and Petković, Branka and Andrić, Deana and Roglić, Goran and Ignjatović, Đurđica and Kostić-Rajačić, Slađana",
year = "2004",
abstract = "Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics (>1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential",
number = "16",
volume = "14",
doi = "10.1016/j.bmcl.2004.06.005",
pages = "4263-4266"
}

Tomić, M., Kundaković, M., Butorović, B., Petković, B., Andrić, D., Roglić, G., Ignjatović, Đ.,& Kostić-Rajačić, S.. (2004). Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd., 14(16), 4263-4266.
https://doi.org/10.1016/j.bmcl.2004.06.005

Tomić M, Kundaković M, Butorović B, Petković B, Andrić D, Roglić G, Ignjatović Đ, Kostić-Rajačić S. Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. in Bioorganic and Medicinal Chemistry Letters. 2004;14(16):4263-4266.
doi:10.1016/j.bmcl.2004.06.005 .

Tomić, Mirko, Kundaković, Marija, Butorović, Biljana, Petković, Branka, Andrić, Deana, Roglić, Goran, Ignjatović, Đurđica, Kostić-Rajačić, Slađana, "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential" in Bioorganic and Medicinal Chemistry Letters, 14, no. 16 (2004):4263-4266,
https://doi.org/10.1016/j.bmcl.2004.06.005 . .

TY  - JOUR
AU  - Pešić, Vesna
AU  - Petković, Branka
AU  - Milanović, Desanka
AU  - Tomić, Mirko
AU  - Veskov, Rosica
AU  - Rakić, Ljubisav
PY  - 2003
UR  - https://www.sciencedirect.com/science/article/pii/S0166432803001426?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3811
AB  - The aim of the present study was to examine motor effects of amphetamine (AMPH) in rats pretreated with either dizocilpine (MK-801) or phencyclidine (PCP), and to estimate possible differences in these effects. Our results showed that AMPH increases the duration of motor effects of PCP, while it does not change motor effects of MK-801. These findings may reflect different mechanisms of action of MK-801 and PCP, as well as selective influence of AMPH on metabolism of these drugs.
PB  - Elsevier
T2  - Behavioural Brain Research
T1  - Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine
IS  - 1-2
VL  - 147
DO  - 10.1016/S0166-4328(03)00142-6
SP  - 211
EP  - 215
ER  - 

@article{
author = "Pešić, Vesna and Petković, Branka and Milanović, Desanka and Tomić, Mirko and Veskov, Rosica and Rakić, Ljubisav",
year = "2003",
abstract = "The aim of the present study was to examine motor effects of amphetamine (AMPH) in rats pretreated with either dizocilpine (MK-801) or phencyclidine (PCP), and to estimate possible differences in these effects. Our results showed that AMPH increases the duration of motor effects of PCP, while it does not change motor effects of MK-801. These findings may reflect different mechanisms of action of MK-801 and PCP, as well as selective influence of AMPH on metabolism of these drugs.",
publisher = "Elsevier",
journal = "Behavioural Brain Research",
title = "Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine",
number = "1-2",
volume = "147",
doi = "10.1016/S0166-4328(03)00142-6",
pages = "211-215"
}

Pešić, V., Petković, B., Milanović, D., Tomić, M., Veskov, R.,& Rakić, L.. (2003). Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine. in Behavioural Brain Research
Elsevier., 147(1-2), 211-215.
https://doi.org/10.1016/S0166-4328(03)00142-6

Pešić V, Petković B, Milanović D, Tomić M, Veskov R, Rakić L. Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine. in Behavioural Brain Research. 2003;147(1-2):211-215.
doi:10.1016/S0166-4328(03)00142-6 .

Pešić, Vesna, Petković, Branka, Milanović, Desanka, Tomić, Mirko, Veskov, Rosica, Rakić, Ljubisav, "Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine" in Behavioural Brain Research, 147, no. 1-2 (2003):211-215,
https://doi.org/10.1016/S0166-4328(03)00142-6 . .