TY  - JOUR
AU  - Miljković, Đorđe
AU  - Trajković, Vladimir
PY  - 2004
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6010
AB  - Interleukin-17 (IL-17) is a proinflammatory T cell cytokine presumably involved in physiological responses to infection, but also in immunopathology of autoimmune disorders such as rheumatoid arthritis. The proinflammatory action of IL-17 depends considerably on its ability to trigger the expression of inducible nitric oxide (NO) synthase (iNOS), an enzyme responsible for the generation of cytotoxic and immunoregulatory free radical NO. Here we discuss the role of IL-17 in the cytokine network controlling iNOS expression, and analyze signaling pathways employed by IL-17 for the initiation of iNOS gene transcription. We also propose biological consequences of IL-17-mediated NO release that could be relevant for the mechanisms or therapy of autoimmune and inflammatory disorders.
PB  - Elsevier
T2  - Cytokine and Growth Factor Reviews
T1  - Inducible nitric oxide synthase activation by interleukin-17
IS  - 1
VL  - 15
DO  - 10.1016/j.cytogfr.2003.10.003
SP  - 21
EP  - 32
ER  - 

@article{
author = "Miljković, Đorđe and Trajković, Vladimir",
year = "2004",
abstract = "Interleukin-17 (IL-17) is a proinflammatory T cell cytokine presumably involved in physiological responses to infection, but also in immunopathology of autoimmune disorders such as rheumatoid arthritis. The proinflammatory action of IL-17 depends considerably on its ability to trigger the expression of inducible nitric oxide (NO) synthase (iNOS), an enzyme responsible for the generation of cytotoxic and immunoregulatory free radical NO. Here we discuss the role of IL-17 in the cytokine network controlling iNOS expression, and analyze signaling pathways employed by IL-17 for the initiation of iNOS gene transcription. We also propose biological consequences of IL-17-mediated NO release that could be relevant for the mechanisms or therapy of autoimmune and inflammatory disorders.",
publisher = "Elsevier",
journal = "Cytokine and Growth Factor Reviews",
title = "Inducible nitric oxide synthase activation by interleukin-17",
number = "1",
volume = "15",
doi = "10.1016/j.cytogfr.2003.10.003",
pages = "21-32"
}

Miljković, Đ.,& Trajković, V.. (2004). Inducible nitric oxide synthase activation by interleukin-17. in Cytokine and Growth Factor Reviews
Elsevier., 15(1), 21-32.
https://doi.org/10.1016/j.cytogfr.2003.10.003

Miljković Đ, Trajković V. Inducible nitric oxide synthase activation by interleukin-17. in Cytokine and Growth Factor Reviews. 2004;15(1):21-32.
doi:10.1016/j.cytogfr.2003.10.003 .

Miljković, Đorđe, Trajković, Vladimir, "Inducible nitric oxide synthase activation by interleukin-17" in Cytokine and Growth Factor Reviews, 15, no. 1 (2004):21-32,
https://doi.org/10.1016/j.cytogfr.2003.10.003 . .