TY  - JOUR
AU  - Trifunović-Momčilov, Milana
AU  - Krstić Milošević, Dijana
AU  - Trifunović, Snežana
AU  - Ćirić, Ana
AU  - Glamočlija, Jasmina
AU  - Jevremović, Slađana
AU  - Subotić, Angelina
PY  - 2019
UR  - http://eemj.eu/index.php/EEMJ/article/view/3962
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3592
AB  - Common centaury, Centaurium erythraea Rafn., represent the best known and the most investigated medicinal plant species of genus Centaurium. Centaury has been used for centuries in traditional medicine. Secondary metabolites such as bitter secoiridoid glucosides (gentiopicrin, swertiamarin and sweroside), xanthones (eustomin and demethyleustomin), and phenolic acids are the main constituents responsible for the therapeutic properties of centaury. Previous investigation showed that overexpression of the AtCKX genes in transgenic centaury plants did not result in a decrease of total cytokinin (CK) content, but in an altered CK profile leading to a decline of bioactive, the most important physiologically active group of CKs.The aim of this study was to investigate antibacterial and antifungal activity of transgenic centaury methanol extracts as well as pure secoiridoid and xanthone compounds on four Gram positive, four Gram negative bacteria and eight species of microfungi. All tested methanol extracts of control and transgenic AtCKX1 centaury shoots and roots showed better antibacterial activity, while pure compounds (gentiopicrin, swertiamarin, eustomin and demethyleustomin) showed better antifungal activity. The results obtained in this work suggest that centaury methanol extracts and pure compounds represent potential antimicrobials confirming the possibility of using these compounds in agronomy, veterinary, medicine or food industry.
PB  - Gheorghe Asachi Technical University of Iasi, Romania
T2  - Environmental Engineering and Management Journal
T1  - Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro
IS  - 9
VL  - 18
SP  - 2063
EP  - 2072
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_3592
ER  - 

@article{
author = "Trifunović-Momčilov, Milana and Krstić Milošević, Dijana and Trifunović, Snežana and Ćirić, Ana and Glamočlija, Jasmina and Jevremović, Slađana and Subotić, Angelina",
year = "2019",
abstract = "Common centaury, Centaurium erythraea Rafn., represent the best known and the most investigated medicinal plant species of genus Centaurium. Centaury has been used for centuries in traditional medicine. Secondary metabolites such as bitter secoiridoid glucosides (gentiopicrin, swertiamarin and sweroside), xanthones (eustomin and demethyleustomin), and phenolic acids are the main constituents responsible for the therapeutic properties of centaury. Previous investigation showed that overexpression of the AtCKX genes in transgenic centaury plants did not result in a decrease of total cytokinin (CK) content, but in an altered CK profile leading to a decline of bioactive, the most important physiologically active group of CKs.The aim of this study was to investigate antibacterial and antifungal activity of transgenic centaury methanol extracts as well as pure secoiridoid and xanthone compounds on four Gram positive, four Gram negative bacteria and eight species of microfungi. All tested methanol extracts of control and transgenic AtCKX1 centaury shoots and roots showed better antibacterial activity, while pure compounds (gentiopicrin, swertiamarin, eustomin and demethyleustomin) showed better antifungal activity. The results obtained in this work suggest that centaury methanol extracts and pure compounds represent potential antimicrobials confirming the possibility of using these compounds in agronomy, veterinary, medicine or food industry.",
publisher = "Gheorghe Asachi Technical University of Iasi, Romania",
journal = "Environmental Engineering and Management Journal",
title = "Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro",
number = "9",
volume = "18",
pages = "2063-2072",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_3592"
}

Trifunović-Momčilov, M., Krstić Milošević, D., Trifunović, S., Ćirić, A., Glamočlija, J., Jevremović, S.,& Subotić, A.. (2019). Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro. in Environmental Engineering and Management Journal
Gheorghe Asachi Technical University of Iasi, Romania., 18(9), 2063-2072.
https://hdl.handle.net/21.15107/rcub_ibiss_3592

Trifunović-Momčilov M, Krstić Milošević D, Trifunović S, Ćirić A, Glamočlija J, Jevremović S, Subotić A. Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro. in Environmental Engineering and Management Journal. 2019;18(9):2063-2072.
https://hdl.handle.net/21.15107/rcub_ibiss_3592 .

Trifunović-Momčilov, Milana, Krstić Milošević, Dijana, Trifunović, Snežana, Ćirić, Ana, Glamočlija, Jasmina, Jevremović, Slađana, Subotić, Angelina, "Antimicrobial activity, antioxidant potential and total phenolic content of transgenic ATCKX1 centaury (Centaurium erythraea Rafn.) Plants grown in vitro" in Environmental Engineering and Management Journal, 18, no. 9 (2019):2063-2072,
https://hdl.handle.net/21.15107/rcub_ibiss_3592 .