@article{
author = "Perović, Milka and Ćirić, Jelena and Matović, Valentina and Srbovan, Maja and Koruga, Đuro and Kanazir, Selma and Ivković, Sanja",
year = "2024",
abstract = "Introduction: In the present study, we assessed the effects of the hyper- harmonized-
hydroxylated fullerene– water complex (3HFWC) on Alzheimer's disease (AD) neuro
pathological hallmarks in 5XFAD mice, an AD animal model.
Methods: The 3- week- old 5XFAD mice were exposed to 3HFWC water solution ad li
bitum for 3 months in the presymptomatic phase of pathology. The functional effects
of the treatment were confirmed through near- infrared spectroscopy (NIRS) analysis
through machine learning (ML) using artificial neural networks (ANNs) to classify the
control and 3HFWC- treated brain tissue samples. The effects of 3HFWC treatment
on amyloid- β (Aβ) accumulation, plaque formation, gliosis, and synaptic plasticity in
cortical and hippocampal tissue were assessed.
Results: The 3HFWC treatment significantly decreased the amyloid- β plaque load in
specific parts of the cerebral cortex. At the same time, 3HFWC treatment did not
induce the activation of glia (astrocytes and microglia) nor did it negatively affect
synaptic protein markers (GAP- 43, synaptophysin, and PSD- 95).
Conclusion: The obtained results point to the potential of 3HFWC, when applied in
the presymptomatic phase of AD, to interfere with amyloid plaque formation without
inducing AD- related pathological processes such as neuroinflammation, gliosis, and
synaptic vulnerability.",
publisher = "Wiley",
journal = "CNS Neuroscience and Therapeutics",
title = "The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease",
number = "3",
volume = "30",
doi = "10.1111/cns.14188",
pages = "e14188"
}
