TY  - JOUR
AU  - Nikolovski, Neda
AU  - Mansilla, María José
AU  - Jevtić, Bojan
AU  - Navarro-Barriuso, Juan
AU  - Saksida, Tamara
AU  - Martínez-Cáceres, Eva M.
AU  - Miljković, Đorđe
PY  - 2019
UR  - https://www.frontiersin.org/article/10.3389/fimmu.2019.00157/full
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6374627
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3280
AB  - Dendritic cells (DC) are professional antigen presenting cells that have a key role in shaping the immune response. Tolerogenic DC (tolDC) have immuno-regulatory properties and they are a promising prospective therapy for multiple sclerosis and other autoimmune diseases. Ethyl pyruvate (EP) is a redox analog of dimethyl fumarate (Tecfidera), a drug for multiple sclerosis treatment. We have recently shown that EP ameliorates experimental autoimmune encephalomyelitis, a multiple sclerosis murine model. Here, we expanded our study to its tolerogenic effects on DC. Phenotypic analysis has shown that DC obtained from mice or humans reduce expression of molecules required for T cell activation such as CD86, CD83, and HLA-DR under the influence of EP, while CD11c expression and viability of DC are not affected. Furthermore, EP-treated DC restrain proliferation and modulate cytokine production of allogeneic lymphocytes. These results demonstrate that EP has the ability to direct DC toward tolDC.
T2  - Frontiers in Immunology
T1  - Ethyl Pyruvate Induces Tolerogenic Dendritic Cells.
VL  - 10
DO  - 10.3389/fimmu.2019.00157
SP  - 157
ER  - 

@article{
author = "Nikolovski, Neda and Mansilla, María José and Jevtić, Bojan and Navarro-Barriuso, Juan and Saksida, Tamara and Martínez-Cáceres, Eva M. and Miljković, Đorđe",
year = "2019",
abstract = "Dendritic cells (DC) are professional antigen presenting cells that have a key role in shaping the immune response. Tolerogenic DC (tolDC) have immuno-regulatory properties and they are a promising prospective therapy for multiple sclerosis and other autoimmune diseases. Ethyl pyruvate (EP) is a redox analog of dimethyl fumarate (Tecfidera), a drug for multiple sclerosis treatment. We have recently shown that EP ameliorates experimental autoimmune encephalomyelitis, a multiple sclerosis murine model. Here, we expanded our study to its tolerogenic effects on DC. Phenotypic analysis has shown that DC obtained from mice or humans reduce expression of molecules required for T cell activation such as CD86, CD83, and HLA-DR under the influence of EP, while CD11c expression and viability of DC are not affected. Furthermore, EP-treated DC restrain proliferation and modulate cytokine production of allogeneic lymphocytes. These results demonstrate that EP has the ability to direct DC toward tolDC.",
journal = "Frontiers in Immunology",
title = "Ethyl Pyruvate Induces Tolerogenic Dendritic Cells.",
volume = "10",
doi = "10.3389/fimmu.2019.00157",
pages = "157"
}

Nikolovski, N., Mansilla, M. J., Jevtić, B., Navarro-Barriuso, J., Saksida, T., Martínez-Cáceres, E. M.,& Miljković, Đ.. (2019). Ethyl Pyruvate Induces Tolerogenic Dendritic Cells.. in Frontiers in Immunology, 10, 157.
https://doi.org/10.3389/fimmu.2019.00157

Nikolovski N, Mansilla MJ, Jevtić B, Navarro-Barriuso J, Saksida T, Martínez-Cáceres EM, Miljković Đ. Ethyl Pyruvate Induces Tolerogenic Dendritic Cells.. in Frontiers in Immunology. 2019;10:157.
doi:10.3389/fimmu.2019.00157 .

Nikolovski, Neda, Mansilla, María José, Jevtić, Bojan, Navarro-Barriuso, Juan, Saksida, Tamara, Martínez-Cáceres, Eva M., Miljković, Đorđe, "Ethyl Pyruvate Induces Tolerogenic Dendritic Cells." in Frontiers in Immunology, 10 (2019):157,
https://doi.org/10.3389/fimmu.2019.00157 . .