TY  - JOUR
AU  - Bartholomaus, Ingo
AU  - Kawakami, Naoto
AU  - Odoardi, Francesca
AU  - Schlager, Christian
AU  - Miljković, Đorđe
AU  - Ellwart, Joachim
AU  - Klinkert, Wolfgang
AU  - Flugel Koch, Cassandra
AU  - Issekutz, Thomas
AU  - Wekerle, Hartmut
AU  - Flugel, Alexander
PY  - 2009
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6023
AB  - The tissues of the central nervous system are effectively shielded from the blood circulation by specialized vessels that are impermeable not only to cells, but also to most macromolecules circulating in the blood. Despite this seemingly absolute seclusion, central nervous system tissues are subject to immune surveillance and are vulnerable to autoimmune attacks. Using intravital two-photon imaging in a Lewis rat model of experimental autoimmune encephalomyelitis, here we present in real-time the interactive processes between effector T cells and cerebral structures from their first arrival to manifest autoimmune disease. We observed that incoming effector T cells successively scanned three planes. The T cells got arrested to leptomeningeal vessels and immediately monitored the luminal surface, crawling preferentially against the blood flow. After diapedesis, the cells continued their scan on the abluminal vascular surface and the underlying leptomeningeal (pial) membrane. There, the T cells encountered phagocytes that effectively present antigens, foreign as well as myelin proteins. These contacts stimulated the effector T cells to produce pro-inflammatory mediators, and provided a trigger to tissue invasion and the formation of inflammatory infiltrations.
PB  - Macmillan Publishers Limited
T2  - Nature
T1  - Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
IS  - 7269
VL  - 462
DO  - 10.1038/nature08478
SP  - 94
EP  - 98
ER  - 

@article{
author = "Bartholomaus, Ingo and Kawakami, Naoto and Odoardi, Francesca and Schlager, Christian and Miljković, Đorđe and Ellwart, Joachim and Klinkert, Wolfgang and Flugel Koch, Cassandra and Issekutz, Thomas and Wekerle, Hartmut and Flugel, Alexander",
year = "2009",
abstract = "The tissues of the central nervous system are effectively shielded from the blood circulation by specialized vessels that are impermeable not only to cells, but also to most macromolecules circulating in the blood. Despite this seemingly absolute seclusion, central nervous system tissues are subject to immune surveillance and are vulnerable to autoimmune attacks. Using intravital two-photon imaging in a Lewis rat model of experimental autoimmune encephalomyelitis, here we present in real-time the interactive processes between effector T cells and cerebral structures from their first arrival to manifest autoimmune disease. We observed that incoming effector T cells successively scanned three planes. The T cells got arrested to leptomeningeal vessels and immediately monitored the luminal surface, crawling preferentially against the blood flow. After diapedesis, the cells continued their scan on the abluminal vascular surface and the underlying leptomeningeal (pial) membrane. There, the T cells encountered phagocytes that effectively present antigens, foreign as well as myelin proteins. These contacts stimulated the effector T cells to produce pro-inflammatory mediators, and provided a trigger to tissue invasion and the formation of inflammatory infiltrations.",
publisher = "Macmillan Publishers Limited",
journal = "Nature",
title = "Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions",
number = "7269",
volume = "462",
doi = "10.1038/nature08478",
pages = "94-98"
}

Bartholomaus, I., Kawakami, N., Odoardi, F., Schlager, C., Miljković, Đ., Ellwart, J., Klinkert, W., Flugel Koch, C., Issekutz, T., Wekerle, H.,& Flugel, A.. (2009). Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. in Nature
Macmillan Publishers Limited., 462(7269), 94-98.
https://doi.org/10.1038/nature08478

Bartholomaus I, Kawakami N, Odoardi F, Schlager C, Miljković Đ, Ellwart J, Klinkert W, Flugel Koch C, Issekutz T, Wekerle H, Flugel A. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. in Nature. 2009;462(7269):94-98.
doi:10.1038/nature08478 .

Bartholomaus, Ingo, Kawakami, Naoto, Odoardi, Francesca, Schlager, Christian, Miljković, Đorđe, Ellwart, Joachim, Klinkert, Wolfgang, Flugel Koch, Cassandra, Issekutz, Thomas, Wekerle, Hartmut, Flugel, Alexander, "Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions" in Nature, 462, no. 7269 (2009):94-98,
https://doi.org/10.1038/nature08478 . .