TY  - JOUR
AU  - Ivanović Matić, Svetlana
AU  - Dinić, Svetlana
AU  - Vujošević, Mladen
AU  - Poznanović, Goran
PY  - 2000
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6966
AB  - The protein composition of hepatocyte nuclear matrices was examined in rats from the 16th day of gestation to 75 days after birth (adult). An overall increase in size of the nuclear matrix was accompanied by quantitative and qualitative changes in its protein content. Quantitative changes of the major proteins of the peripheral lamina surrounding the isolated nuclear matrix were detected. By Western analysis we established that in pre- and postnatal nuclear matrices the relative concentrations of lamin C were greater than lamin A. After birth, the relative concentrations of both lamins progressively increased. In the adult nuclear matrix, the concentration of lamin A was greater than lamin C. In contrast, the relative concentrations of lamin B remained unchanged throughout development and growth. The relative concentrations of two nuclear matrix-associated regulatory proteins studied changed with development and growth: transcription factor C/EBP alpha isoforms, which were detected during the gestation period, increased notably after the first postnatal day, attaining a maximum at the adult stage; the high concentrations of the proliferating cell nuclear antigen (PCNA) perceptibly decreased after the 21st prenatal day. Changes in the composition of the nuclear matrix protein suggest that this structure coordinates nuclear functioning during cell differentiation.
PB  - John Wiley and Sons
T2  - IUBMB Life
T1  - The protein composition of the hepatocyte nuclear matrix is differentiation-stage specific
IS  - 6
VL  - 49
DO  - 10.1080/15216540050167052
SP  - 511
EP  - 517
ER  - 

@article{
author = "Ivanović Matić, Svetlana and Dinić, Svetlana and Vujošević, Mladen and Poznanović, Goran",
year = "2000",
abstract = "The protein composition of hepatocyte nuclear matrices was examined in rats from the 16th day of gestation to 75 days after birth (adult). An overall increase in size of the nuclear matrix was accompanied by quantitative and qualitative changes in its protein content. Quantitative changes of the major proteins of the peripheral lamina surrounding the isolated nuclear matrix were detected. By Western analysis we established that in pre- and postnatal nuclear matrices the relative concentrations of lamin C were greater than lamin A. After birth, the relative concentrations of both lamins progressively increased. In the adult nuclear matrix, the concentration of lamin A was greater than lamin C. In contrast, the relative concentrations of lamin B remained unchanged throughout development and growth. The relative concentrations of two nuclear matrix-associated regulatory proteins studied changed with development and growth: transcription factor C/EBP alpha isoforms, which were detected during the gestation period, increased notably after the first postnatal day, attaining a maximum at the adult stage; the high concentrations of the proliferating cell nuclear antigen (PCNA) perceptibly decreased after the 21st prenatal day. Changes in the composition of the nuclear matrix protein suggest that this structure coordinates nuclear functioning during cell differentiation.",
publisher = "John Wiley and Sons",
journal = "IUBMB Life",
title = "The protein composition of the hepatocyte nuclear matrix is differentiation-stage specific",
number = "6",
volume = "49",
doi = "10.1080/15216540050167052",
pages = "511-517"
}

Ivanović Matić, S., Dinić, S., Vujošević, M.,& Poznanović, G.. (2000). The protein composition of the hepatocyte nuclear matrix is differentiation-stage specific. in IUBMB Life
John Wiley and Sons., 49(6), 511-517.
https://doi.org/10.1080/15216540050167052

Ivanović Matić S, Dinić S, Vujošević M, Poznanović G. The protein composition of the hepatocyte nuclear matrix is differentiation-stage specific. in IUBMB Life. 2000;49(6):511-517.
doi:10.1080/15216540050167052 .

Ivanović Matić, Svetlana, Dinić, Svetlana, Vujošević, Mladen, Poznanović, Goran, "The protein composition of the hepatocyte nuclear matrix is differentiation-stage specific" in IUBMB Life, 49, no. 6 (2000):511-517,
https://doi.org/10.1080/15216540050167052 . .