TY  - JOUR
AU  - Richter, Stefan
AU  - Singh, Sushma
AU  - Drača, Dijana
AU  - Kate, Anup
AU  - Kumbhar, Anupa
AU  - Kumbhar, Avinash S.
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Lönnecke, Peter
AU  - Hey-Hawkins, Evamarie
PY  - 2016
UR  - http://xlink.rsc.org/?DOI=C6DT01782G
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27264161
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2847
AB  - A series of Ru(II) arene complexes of mono- and bidentate N-donor ligands with carboxyl or ester groups and chlorido ancillary ligands were synthesised and structurally characterised. The complexes have a distorted tetrahedral piano-stool geometry. The binding interaction was studied with calf thymus DNA (CT-DNA) by absorption titration, viscosity measurement, thermal melting, circular dichroism, ethidium bromide displacement assay and DNA cleavage of plasmid DNA (pBR322), investigated by gel electrophoresis. The dichlorido complexes bind covalently to DNA in the dark, similar to cisplatin, while the monochlorido complexes bind covalently on irradiation, similar to cisplatin analogues. The compounds are selectively cytotoxic against several tumour cell lines and show specific nonlinear correlation between dose and activity. This phenomenon is closely related to their potential to act preferentially as inhibitors of cell division.
T2  - Dalton Transactions
T1  - Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands
IS  - 33
VL  - 45
DO  - 10.1039/c6dt01782g
SP  - 13114
EP  - 13125
ER  - 

@article{
author = "Richter, Stefan and Singh, Sushma and Drača, Dijana and Kate, Anup and Kumbhar, Anupa and Kumbhar, Avinash S. and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Lönnecke, Peter and Hey-Hawkins, Evamarie",
year = "2016",
abstract = "A series of Ru(II) arene complexes of mono- and bidentate N-donor ligands with carboxyl or ester groups and chlorido ancillary ligands were synthesised and structurally characterised. The complexes have a distorted tetrahedral piano-stool geometry. The binding interaction was studied with calf thymus DNA (CT-DNA) by absorption titration, viscosity measurement, thermal melting, circular dichroism, ethidium bromide displacement assay and DNA cleavage of plasmid DNA (pBR322), investigated by gel electrophoresis. The dichlorido complexes bind covalently to DNA in the dark, similar to cisplatin, while the monochlorido complexes bind covalently on irradiation, similar to cisplatin analogues. The compounds are selectively cytotoxic against several tumour cell lines and show specific nonlinear correlation between dose and activity. This phenomenon is closely related to their potential to act preferentially as inhibitors of cell division.",
journal = "Dalton Transactions",
title = "Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands",
number = "33",
volume = "45",
doi = "10.1039/c6dt01782g",
pages = "13114-13125"
}

Richter, S., Singh, S., Drača, D., Kate, A., Kumbhar, A., Kumbhar, A. S., Maksimović-Ivanić, D., Mijatović, S., Lönnecke, P.,& Hey-Hawkins, E.. (2016). Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands. in Dalton Transactions, 45(33), 13114-13125.
https://doi.org/10.1039/c6dt01782g

Richter S, Singh S, Drača D, Kate A, Kumbhar A, Kumbhar AS, Maksimović-Ivanić D, Mijatović S, Lönnecke P, Hey-Hawkins E. Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands. in Dalton Transactions. 2016;45(33):13114-13125.
doi:10.1039/c6dt01782g .

Richter, Stefan, Singh, Sushma, Drača, Dijana, Kate, Anup, Kumbhar, Anupa, Kumbhar, Avinash S., Maksimović-Ivanić, Danijela, Mijatović, Sanja, Lönnecke, Peter, Hey-Hawkins, Evamarie, "Antiproliferative activity of ruthenium(ii) arene complexes with mono- and bidentate pyridine-based ligands" in Dalton Transactions, 45, no. 33 (2016):13114-13125,
https://doi.org/10.1039/c6dt01782g . .