TY  - CONF
AU  - Jovanović, Mirna
AU  - Bangay, Gabrielle
AU  - Jovanović Stojanov, Sofija
AU  - Dragoj, Miodrag
AU  - Stepanović, Ana
AU  - Lupšić, Ema
AU  - Podolski-Renić, Ana
AU  - Dinić, Jelena
AU  - Rijo, Patricia
AU  - Pešić, Milica
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5369
AB  - Plants of the genus Plectranthus (Lamiaceae) are used in traditional medicine. Here, the anti-cancer effects of the three abietane diterpenoid derivatives from Plectranthus species are described. Compounds’ effects (comp. 1 = VI31.1.1, comp. 2 = VI20.1.1, comp. 3 = RoyBz) were tested
in human lung cancer cells, in sensitive NCI-H460 and chemoresistant NCI-H460/R, as well as in colon cancer cells, sensitive DLD1, and hemoresistant DLD1-TxR. The resistant cells were more sensitive than corresponding parental cells to 1 and 2 in MTT assay, with IC50 values ranging from 3 to 10 μM. For the most potent 3 (IC50 as low as 1 μM), resistant cells had up to 2 times higher IC50 values than sensitive cells. The growth inhibition effect by all three compounds was more ronounced in cancer cells, compared to normal human fibroblasts (MRC-5). Only 2 induced a significant cell death effect showing 70% non-viable cells in NCI-H460. The effect the compoundsmight have on the P-gp extrusion pump was also tested using doxorubicin and rhodamine 123 accumulation assays. Compounds 1 and 2 caused a significant increase in the accumulation of both P-gp substrates, doxorubicin, and rhodamine 123. The compounds isolated from Plectranthus showed anticancer potential in lung and colon cancer cells. Importantly, they displayed colateral sensitivity - a phenomenon when the chemoresistant cells are more sensitive to the compounds than corresponding sensitive cells. The compounds inhibited the P-gp activity implying MDR modulating potential.
PB  - Belgrade: Serbian Plant Physiology Society
C3  - 4th International Conference on Plant Biology [and] 23rd SPPS Meeting; 2022 Oct 6-8; Belgrade, Serbia
T1  - Multidrug-resistant cancer cells are sensitive to abietane diterpenoids from Plectranthus species
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5369
ER  - 

@conference{
author = "Jovanović, Mirna and Bangay, Gabrielle and Jovanović Stojanov, Sofija and Dragoj, Miodrag and Stepanović, Ana and Lupšić, Ema and Podolski-Renić, Ana and Dinić, Jelena and Rijo, Patricia and Pešić, Milica",
year = "2022",
abstract = "Plants of the genus Plectranthus (Lamiaceae) are used in traditional medicine. Here, the anti-cancer effects of the three abietane diterpenoid derivatives from Plectranthus species are described. Compounds’ effects (comp. 1 = VI31.1.1, comp. 2 = VI20.1.1, comp. 3 = RoyBz) were tested
in human lung cancer cells, in sensitive NCI-H460 and chemoresistant NCI-H460/R, as well as in colon cancer cells, sensitive DLD1, and hemoresistant DLD1-TxR. The resistant cells were more sensitive than corresponding parental cells to 1 and 2 in MTT assay, with IC50 values ranging from 3 to 10 μM. For the most potent 3 (IC50 as low as 1 μM), resistant cells had up to 2 times higher IC50 values than sensitive cells. The growth inhibition effect by all three compounds was more ronounced in cancer cells, compared to normal human fibroblasts (MRC-5). Only 2 induced a significant cell death effect showing 70% non-viable cells in NCI-H460. The effect the compoundsmight have on the P-gp extrusion pump was also tested using doxorubicin and rhodamine 123 accumulation assays. Compounds 1 and 2 caused a significant increase in the accumulation of both P-gp substrates, doxorubicin, and rhodamine 123. The compounds isolated from Plectranthus showed anticancer potential in lung and colon cancer cells. Importantly, they displayed colateral sensitivity - a phenomenon when the chemoresistant cells are more sensitive to the compounds than corresponding sensitive cells. The compounds inhibited the P-gp activity implying MDR modulating potential.",
publisher = "Belgrade: Serbian Plant Physiology Society",
journal = "4th International Conference on Plant Biology [and] 23rd SPPS Meeting; 2022 Oct 6-8; Belgrade, Serbia",
title = "Multidrug-resistant cancer cells are sensitive to abietane diterpenoids from Plectranthus species",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5369"
}

Jovanović, M., Bangay, G., Jovanović Stojanov, S., Dragoj, M., Stepanović, A., Lupšić, E., Podolski-Renić, A., Dinić, J., Rijo, P.,& Pešić, M.. (2022). Multidrug-resistant cancer cells are sensitive to abietane diterpenoids from Plectranthus species. in 4th International Conference on Plant Biology [and] 23rd SPPS Meeting; 2022 Oct 6-8; Belgrade, Serbia
Belgrade: Serbian Plant Physiology Society..
https://hdl.handle.net/21.15107/rcub_ibiss_5369

Jovanović M, Bangay G, Jovanović Stojanov S, Dragoj M, Stepanović A, Lupšić E, Podolski-Renić A, Dinić J, Rijo P, Pešić M. Multidrug-resistant cancer cells are sensitive to abietane diterpenoids from Plectranthus species. in 4th International Conference on Plant Biology [and] 23rd SPPS Meeting; 2022 Oct 6-8; Belgrade, Serbia. 2022;.
https://hdl.handle.net/21.15107/rcub_ibiss_5369 .

Jovanović, Mirna, Bangay, Gabrielle, Jovanović Stojanov, Sofija, Dragoj, Miodrag, Stepanović, Ana, Lupšić, Ema, Podolski-Renić, Ana, Dinić, Jelena, Rijo, Patricia, Pešić, Milica, "Multidrug-resistant cancer cells are sensitive to abietane diterpenoids from Plectranthus species" in 4th International Conference on Plant Biology [and] 23rd SPPS Meeting; 2022 Oct 6-8; Belgrade, Serbia (2022),
https://hdl.handle.net/21.15107/rcub_ibiss_5369 .