TY  - CONF
AU  - Krajnović, Tamara
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Wessjohann, Ludger A.
AU  - Kaluđerović, Goran N.
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5289
AB  - Prenylflavonoid from hops - xanthohumol (XN) has been shown to possess diverse biological properties, including strong anticancer activity. One of the possibilities for improving delivery and effectiveness of drugs is the use of mesoporous silica nanoparticles such as nontoxic SBA-15. The aim of this study was the evaluation of the in vitro anticancer potential of XN loaded with different amounts into SBA-15 particles against malignant mouse melanoma B16-F10 cells. Our data indicate that SBA-15 containing XN showed a loading rate–activity dependence. Importantly, immobilization of XN into SBA-15 preserved and even potentiated its antitumor potential, in comparison to its free form. Also, by loading into SBA-15 carrier, XNs’ anticancer mode of action converted from predominantly cytotoxic to cytostatic, resulting in a reduction of dividing potential. In addition, contrasting the previously observed apoptotic-inducing property of free XN, immobilized XN induced autophagic cell death that might be important for disabling tumor repopulation in response to apoptotic-induced cell proliferation, a mechanism often asscociated with therapy failure of advanced forms of cancer1.
PB  - Belgrade: Faculty of Chemistry
C3  - Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
T1  - Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells
SP  - 87
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5289
ER  - 

@conference{
author = "Krajnović, Tamara and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Wessjohann, Ludger A. and Kaluđerović, Goran N.",
year = "2022",
abstract = "Prenylflavonoid from hops - xanthohumol (XN) has been shown to possess diverse biological properties, including strong anticancer activity. One of the possibilities for improving delivery and effectiveness of drugs is the use of mesoporous silica nanoparticles such as nontoxic SBA-15. The aim of this study was the evaluation of the in vitro anticancer potential of XN loaded with different amounts into SBA-15 particles against malignant mouse melanoma B16-F10 cells. Our data indicate that SBA-15 containing XN showed a loading rate–activity dependence. Importantly, immobilization of XN into SBA-15 preserved and even potentiated its antitumor potential, in comparison to its free form. Also, by loading into SBA-15 carrier, XNs’ anticancer mode of action converted from predominantly cytotoxic to cytostatic, resulting in a reduction of dividing potential. In addition, contrasting the previously observed apoptotic-inducing property of free XN, immobilized XN induced autophagic cell death that might be important for disabling tumor repopulation in response to apoptotic-induced cell proliferation, a mechanism often asscociated with therapy failure of advanced forms of cancer1.",
publisher = "Belgrade: Faculty of Chemistry",
journal = "Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia",
title = "Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells",
pages = "87",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5289"
}

Krajnović, T., Maksimović-Ivanić, D., Mijatović, S., Wessjohann, L. A.,& Kaluđerović, G. N.. (2022). Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
Belgrade: Faculty of Chemistry., 87.
https://hdl.handle.net/21.15107/rcub_ibiss_5289

Krajnović T, Maksimović-Ivanić D, Mijatović S, Wessjohann LA, Kaluđerović GN. Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia. 2022;:87.
https://hdl.handle.net/21.15107/rcub_ibiss_5289 .

Krajnović, Tamara, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Wessjohann, Ludger A., Kaluđerović, Goran N., "Anticancer potential of xanthohumol loaded into SBA-15 mesoporous silica particles against B16-F10 cells" in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia (2022):87,
https://hdl.handle.net/21.15107/rcub_ibiss_5289 .