TY  - JOUR
AU  - Monfoulet, Laurent‐Emmanuel
AU  - Ruskovska, Tatjana
AU  - Ajdžanović, Vladimir
AU  - Havlik, Jaroslav
AU  - Vauzour, David
AU  - Bayram, Banu
AU  - Krga, Irena
AU  - Corral-Jara, Karla-Fabiola
AU  - Kistanova, Elena
AU  - Abadjieva, Desislava
AU  - Massaro, Marika
AU  - Scoditti, Egeria
AU  - Deligiannidou, Eirini
AU  - Kontogiorgis, Christos
AU  - Arola-Arnal, Anna
AU  - van Schothorst, Evert M
AU  - Morand, Christine
AU  - Milenkovic, Dragan
PY  - 2021
UR  - https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202100227
UR  - http://www.ncbi.nlm.nih.gov/pubmed/34048642
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4437
AB  - SCOPE Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. METHODS AND RESULTS To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. CONCLUSION This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives.
PB  - John Wiley and Sons
T2  - Molecular Nutrition & Food Research
T2  - Molecular Nutrition & Food Research
T1  - Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.
IS  - 16
VL  - 65
DO  - 10.1002/mnfr.202100227
SP  - e2100227
ER  - 

@article{
author = "Monfoulet, Laurent‐Emmanuel and Ruskovska, Tatjana and Ajdžanović, Vladimir and Havlik, Jaroslav and Vauzour, David and Bayram, Banu and Krga, Irena and Corral-Jara, Karla-Fabiola and Kistanova, Elena and Abadjieva, Desislava and Massaro, Marika and Scoditti, Egeria and Deligiannidou, Eirini and Kontogiorgis, Christos and Arola-Arnal, Anna and van Schothorst, Evert M and Morand, Christine and Milenkovic, Dragan",
year = "2021",
abstract = "SCOPE Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. METHODS AND RESULTS To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. CONCLUSION This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives.",
publisher = "John Wiley and Sons",
journal = "Molecular Nutrition & Food Research, Molecular Nutrition & Food Research",
title = "Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.",
number = "16",
volume = "65",
doi = "10.1002/mnfr.202100227",
pages = "e2100227"
}

Monfoulet, L., Ruskovska, T., Ajdžanović, V., Havlik, J., Vauzour, D., Bayram, B., Krga, I., Corral-Jara, K., Kistanova, E., Abadjieva, D., Massaro, M., Scoditti, E., Deligiannidou, E., Kontogiorgis, C., Arola-Arnal, A., van Schothorst, E. M., Morand, C.,& Milenkovic, D.. (2021). Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.. in Molecular Nutrition & Food Research
John Wiley and Sons., 65(16), e2100227.
https://doi.org/10.1002/mnfr.202100227

Monfoulet L, Ruskovska T, Ajdžanović V, Havlik J, Vauzour D, Bayram B, Krga I, Corral-Jara K, Kistanova E, Abadjieva D, Massaro M, Scoditti E, Deligiannidou E, Kontogiorgis C, Arola-Arnal A, van Schothorst EM, Morand C, Milenkovic D. Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.. in Molecular Nutrition & Food Research. 2021;65(16):e2100227.
doi:10.1002/mnfr.202100227 .

Monfoulet, Laurent‐Emmanuel, Ruskovska, Tatjana, Ajdžanović, Vladimir, Havlik, Jaroslav, Vauzour, David, Bayram, Banu, Krga, Irena, Corral-Jara, Karla-Fabiola, Kistanova, Elena, Abadjieva, Desislava, Massaro, Marika, Scoditti, Egeria, Deligiannidou, Eirini, Kontogiorgis, Christos, Arola-Arnal, Anna, van Schothorst, Evert M, Morand, Christine, Milenkovic, Dragan, "Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies." in Molecular Nutrition & Food Research, 65, no. 16 (2021):e2100227,
https://doi.org/10.1002/mnfr.202100227 . .