@article{
author = "Tomić, Mirko and Kundaković, Marija and Butorović, Biljana and Petković, Branka and Andrić, Deana and Roglić, Goran and Ignjatović, Đurđica and Kostić-Rajačić, Slađana",
year = "2004",
abstract = "Six active compounds, among previously synthesized and screened arylpiperazines, were selected and evaluated for the binding affinity to rat dopamine, serotonin and alpha(1) receptors. Two compounds with benztriazole group had a 5-HT2A/D-2 binding ratio characteristic for atypical neuroleptics (>1, pK(i) values). Compound 2, 5-{2-[4-(2,3-dimethyl-phenyl)-piperazin-1-yl]ethyl}1H-benzotriazole, expressed clozapine-like in vitro binding profile at D-2, 5-HT2A and alpha1 receptors and a higher affinity for 5-HT1A receptors than clozapine. Also, it exhibited the noncataleptic behavioural pattern of atypical antipsychotics and antagonized d-amphetamine-induced hyperlocomotion in rats.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Bioorganic and Medicinal Chemistry Letters",
title = "Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential",
number = "16",
volume = "14",
doi = "10.1016/j.bmcl.2004.06.005",
pages = "4263-4266"
}