TY  - JOUR
AU  - Čapo, Ivan
AU  - Milenković, Ivan
AU  - Čapo, Nataša
AU  - Stilinović, Nebojša
AU  - Vukmirović, Saša
AU  - Teofilovic, Branislava
AU  - Petković, Branka
AU  - Sekulić, Slobodan
PY  - 2020
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46642000041C
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4102
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/6035
AB  - The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses
IS  - 4
VL  - 72
DO  - 10.2298/ABS200619041C
SP  - 473
EP  - 482
ER  - 

@article{
author = "Čapo, Ivan and Milenković, Ivan and Čapo, Nataša and Stilinović, Nebojša and Vukmirović, Saša and Teofilovic, Branislava and Petković, Branka and Sekulić, Slobodan",
year = "2020",
abstract = "The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses",
number = "4",
volume = "72",
doi = "10.2298/ABS200619041C",
pages = "473-482"
}

Čapo, I., Milenković, I., Čapo, N., Stilinović, N., Vukmirović, S., Teofilovic, B., Petković, B.,& Sekulić, S.. (2020). Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses. in Archives of Biological Sciences
Serbian Biological Society., 72(4), 473-482.
https://doi.org/10.2298/ABS200619041C

Čapo I, Milenković I, Čapo N, Stilinović N, Vukmirović S, Teofilovic B, Petković B, Sekulić S. Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses. in Archives of Biological Sciences. 2020;72(4):473-482.
doi:10.2298/ABS200619041C .

Čapo, Ivan, Milenković, Ivan, Čapo, Nataša, Stilinović, Nebojša, Vukmirović, Saša, Teofilovic, Branislava, Petković, Branka, Sekulić, Slobodan, "Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses" in Archives of Biological Sciences, 72, no. 4 (2020):473-482,
https://doi.org/10.2298/ABS200619041C . .