TY  - JOUR
AU  - Radenović, Lidija
AU  - Selaković, Vesna
AU  - Olivan, Sara
AU  - Calvo, Ana Cristina
AU  - Rando, Amaya
AU  - Petković, Branka
AU  - Osta, Rosario
PY  - 2014
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0361923013001871
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3787
AB  - The tetanus toxin C (TTC) fragment capacity of being transported in a retrograde way through motoneurons and its nontoxic nature opens the door to a new promising therapeutic strategy for neurodegenerative diseases. In this study, the TTC effect was tested for the first time in animal model of global cerebral ischemia induced by 10-min occlusion of both common carotid arteries. The aim was to evaluate the effect of TTC gene therapy treatment on the development and expression of global cerebral ischemia/reperfusion-induced oxidative stress and motor hyperactivity in Mongolian gerbils. Several oxidative stress and motor behavioral parameters were investigated between 2 h and 14 days after reperfusion. Neuroprotective efficiency of TTC was observed in the forebrain cortex, striatum, hippocampus, and cerebellum at the level of each examined oxidative stress parameter (nitric oxide level, superoxide production, superoxide dismutase activity, and index of lipid peroxidation). Additionally, TTC significantly decreased ischemia-induced motor hyperactivity based on tested parameters (locomotion, stereotypy, and rotations). As judged by biochemical as well as behavioral data, treatment with TTC for the first time showed neuroprotective efficiency by reduction of ischemia-induced oxidative stress and motor hyperactivity and can be a promising strategy for ischemia-induced neuronal damage treatment.
PB  - Pergamon-Elsevier Science Ltd
T2  - Brain Research Bulletin
T1  - Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils
VL  - 101
DO  - 10.1016/j.brainresbull.2013.11.006
SP  - 37
EP  - 44
ER  - 

@article{
author = "Radenović, Lidija and Selaković, Vesna and Olivan, Sara and Calvo, Ana Cristina and Rando, Amaya and Petković, Branka and Osta, Rosario",
year = "2014",
abstract = "The tetanus toxin C (TTC) fragment capacity of being transported in a retrograde way through motoneurons and its nontoxic nature opens the door to a new promising therapeutic strategy for neurodegenerative diseases. In this study, the TTC effect was tested for the first time in animal model of global cerebral ischemia induced by 10-min occlusion of both common carotid arteries. The aim was to evaluate the effect of TTC gene therapy treatment on the development and expression of global cerebral ischemia/reperfusion-induced oxidative stress and motor hyperactivity in Mongolian gerbils. Several oxidative stress and motor behavioral parameters were investigated between 2 h and 14 days after reperfusion. Neuroprotective efficiency of TTC was observed in the forebrain cortex, striatum, hippocampus, and cerebellum at the level of each examined oxidative stress parameter (nitric oxide level, superoxide production, superoxide dismutase activity, and index of lipid peroxidation). Additionally, TTC significantly decreased ischemia-induced motor hyperactivity based on tested parameters (locomotion, stereotypy, and rotations). As judged by biochemical as well as behavioral data, treatment with TTC for the first time showed neuroprotective efficiency by reduction of ischemia-induced oxidative stress and motor hyperactivity and can be a promising strategy for ischemia-induced neuronal damage treatment.",
publisher = "Pergamon-Elsevier Science Ltd",
journal = "Brain Research Bulletin",
title = "Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils",
volume = "101",
doi = "10.1016/j.brainresbull.2013.11.006",
pages = "37-44"
}

Radenović, L., Selaković, V., Olivan, S., Calvo, A. C., Rando, A., Petković, B.,& Osta, R.. (2014). Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils. in Brain Research Bulletin
Pergamon-Elsevier Science Ltd., 101, 37-44.
https://doi.org/10.1016/j.brainresbull.2013.11.006

Radenović L, Selaković V, Olivan S, Calvo AC, Rando A, Petković B, Osta R. Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils. in Brain Research Bulletin. 2014;101:37-44.
doi:10.1016/j.brainresbull.2013.11.006 .

Radenović, Lidija, Selaković, Vesna, Olivan, Sara, Calvo, Ana Cristina, Rando, Amaya, Petković, Branka, Osta, Rosario, "Neuroprotective efficiency of tetanus toxin C fragment in model of global cerebral ischemia in Mongolian gerbils" in Brain Research Bulletin, 101 (2014):37-44,
https://doi.org/10.1016/j.brainresbull.2013.11.006 . .

TY  - JOUR
AU  - Rauš Balind, Snežana
AU  - Selaković, Vesna
AU  - Radenović, Lidija
AU  - Prolić, Zlatko
AU  - Petković, Branka
PY  - 2014
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088921
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3788
AB  - Magnetic field as ecological factor has influence on all living beings. The aim of this study was to determine if extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affects oxidative stress in the brain of gerbils submitted to 10-min global cerebral ischemia. After occlusion of both carotid arteries, 3-month-old gerbils were continuously exposed to ELF-MF for 7 days. Nitric oxide and superoxide anion production, superoxide dismutase activity and index of lipid peroxidation were examined in the forebrain cortex, striatum and hippocampus on the 7th (immediate effect of ELF-MF) and 14th day after reperfusion (delayed effect of ELF-MF). Ischemia per se increased oxidative stress in the brain on the 7th and 14th day after reperfusion. ELF-MF also increased oxidative stress, but to a greater extent than ischemia, only immediately after cessation of exposure. Ischemic gerbils exposed to ELF-MF had increased oxidative stress parameters on the 7th day after reperfusion, but to a lesser extent than ischemic or ELF-MF-exposed animals. On the 14th day after reperfusion, oxidative stress parameters in the brain of these gerbils were mostly at the control levels. Applied ELF-MF decreases oxidative stress induced by global cerebral ischemia and thereby reduces possible negative consequences which free radical species could have in the brain. The results presented here indicate a beneficial effect of ELF-MF (50 Hz, 0.5 mT) in the model of global cerebral ischemia.
PB  - Public Library of Science
T2  - PLoS One
T1  - Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia
IS  - 2
IS  - 2
VL  - 9
DO  - 10.1371/journal.pone.0088921
SP  - e88921
ER  - 

@article{
author = "Rauš Balind, Snežana and Selaković, Vesna and Radenović, Lidija and Prolić, Zlatko and Petković, Branka",
year = "2014",
abstract = "Magnetic field as ecological factor has influence on all living beings. The aim of this study was to determine if extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affects oxidative stress in the brain of gerbils submitted to 10-min global cerebral ischemia. After occlusion of both carotid arteries, 3-month-old gerbils were continuously exposed to ELF-MF for 7 days. Nitric oxide and superoxide anion production, superoxide dismutase activity and index of lipid peroxidation were examined in the forebrain cortex, striatum and hippocampus on the 7th (immediate effect of ELF-MF) and 14th day after reperfusion (delayed effect of ELF-MF). Ischemia per se increased oxidative stress in the brain on the 7th and 14th day after reperfusion. ELF-MF also increased oxidative stress, but to a greater extent than ischemia, only immediately after cessation of exposure. Ischemic gerbils exposed to ELF-MF had increased oxidative stress parameters on the 7th day after reperfusion, but to a lesser extent than ischemic or ELF-MF-exposed animals. On the 14th day after reperfusion, oxidative stress parameters in the brain of these gerbils were mostly at the control levels. Applied ELF-MF decreases oxidative stress induced by global cerebral ischemia and thereby reduces possible negative consequences which free radical species could have in the brain. The results presented here indicate a beneficial effect of ELF-MF (50 Hz, 0.5 mT) in the model of global cerebral ischemia.",
publisher = "Public Library of Science",
journal = "PLoS One",
title = "Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia",
number = "2, 2",
volume = "9",
doi = "10.1371/journal.pone.0088921",
pages = "e88921"
}

Rauš Balind, S., Selaković, V., Radenović, L., Prolić, Z.,& Petković, B.. (2014). Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia. in PLoS One
Public Library of Science., 9(2), e88921.
https://doi.org/10.1371/journal.pone.0088921

Rauš Balind S, Selaković V, Radenović L, Prolić Z, Petković B. Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia. in PLoS One. 2014;9(2):e88921.
doi:10.1371/journal.pone.0088921 .

Rauš Balind, Snežana, Selaković, Vesna, Radenović, Lidija, Prolić, Zlatko, Petković, Branka, "Extremely Low Frequency Magnetic Field (50 Hz, 0.5 mT) Reduces Oxidative Stress in the Brain of Gerbils Submitted to Global Cerebral Ischemia" in PLoS One, 9, no. 2 (2014):e88921,
https://doi.org/10.1371/journal.pone.0088921 . .