TY  - JOUR
AU  - Mihajlović, Ekatarina
AU  - Biancalana, Lorenzo
AU  - Jelača, Sanja
AU  - Chiaverini, Lorenzo
AU  - Dojčinović, Biljana
AU  - Dunđerović, Duško
AU  - Zacchini, Stefano
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Marchetti, Fabio
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6701
AB  - FETPY, an organo-diiron(I) complex, showed strong cytotoxicity across a panel of human and mouse cancer cell lines, combined with an outstanding selectivity compared to nonmalignant cells. Enhanced iron uptake in aggressive, low-differentiated cell lines, caused membrane lipid peroxidation, which resulted in ferroptosis in human ovarian cancer cells. FETPY induced significant morphological changes in murine B16–F1 and B16–F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential. Additionally, FETPY substantially suppressed tumor growth in low- and high-grade syngeneic melanoma models when administered in a therapeutic regimen. FETPY is featured by satisfactory water solubility (millimolar range), an amphiphilic character (Log Pow = −0.17), and excellent stability in a biological medium (DMEM). These important requisites for drug development are rarely met in iron complexes investigated so far as possible anticancer agents. Overall, FETPY holds promise as a safe and potent targeted antitumor agent.
PB  - American Chemical Society
T2  - Journal of Medicinal Chemistry
T1  - FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo
IS  - 9
VL  - 67
DO  - 10.1021/acs.jmedchem.4c00377
SP  - 7553
EP  - 7568
ER  - 

@article{
author = "Mihajlović, Ekatarina and Biancalana, Lorenzo and Jelača, Sanja and Chiaverini, Lorenzo and Dojčinović, Biljana and Dunđerović, Duško and Zacchini, Stefano and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Marchetti, Fabio",
year = "2024",
abstract = "FETPY, an organo-diiron(I) complex, showed strong cytotoxicity across a panel of human and mouse cancer cell lines, combined with an outstanding selectivity compared to nonmalignant cells. Enhanced iron uptake in aggressive, low-differentiated cell lines, caused membrane lipid peroxidation, which resulted in ferroptosis in human ovarian cancer cells. FETPY induced significant morphological changes in murine B16–F1 and B16–F10 melanoma cells, leading to senescence and/or trans-differentiation into Schwann-like cells, thus significantly reducing their tumorigenic potential. Additionally, FETPY substantially suppressed tumor growth in low- and high-grade syngeneic melanoma models when administered in a therapeutic regimen. FETPY is featured by satisfactory water solubility (millimolar range), an amphiphilic character (Log Pow = −0.17), and excellent stability in a biological medium (DMEM). These important requisites for drug development are rarely met in iron complexes investigated so far as possible anticancer agents. Overall, FETPY holds promise as a safe and potent targeted antitumor agent.",
publisher = "American Chemical Society",
journal = "Journal of Medicinal Chemistry",
title = "FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo",
number = "9",
volume = "67",
doi = "10.1021/acs.jmedchem.4c00377",
pages = "7553-7568"
}

Mihajlović, E., Biancalana, L., Jelača, S., Chiaverini, L., Dojčinović, B., Dunđerović, D., Zacchini, S., Mijatović, S., Maksimović-Ivanić, D.,& Marchetti, F.. (2024). FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo. in Journal of Medicinal Chemistry
American Chemical Society., 67(9), 7553-7568.
https://doi.org/10.1021/acs.jmedchem.4c00377

Mihajlović E, Biancalana L, Jelača S, Chiaverini L, Dojčinović B, Dunđerović D, Zacchini S, Mijatović S, Maksimović-Ivanić D, Marchetti F. FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo. in Journal of Medicinal Chemistry. 2024;67(9):7553-7568.
doi:10.1021/acs.jmedchem.4c00377 .

Mihajlović, Ekatarina, Biancalana, Lorenzo, Jelača, Sanja, Chiaverini, Lorenzo, Dojčinović, Biljana, Dunđerović, Duško, Zacchini, Stefano, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Marchetti, Fabio, "FETPY: a Diiron(I) Thio–Carbyne Complex with Prominent Anticancer Activity In Vitro and In Vivo" in Journal of Medicinal Chemistry, 67, no. 9 (2024):7553-7568,
https://doi.org/10.1021/acs.jmedchem.4c00377 . .