TY  - JOUR
AU  - Božić, Iva
AU  - Savić, Danijela
AU  - Lavrnja, Irena
PY  - 2021
UR  - http://www.ncbi.nlm.nih.gov/pubmed/33226087
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4404
AB  - Astrocytes, the most abundant glial cells in the central nervous system (CNS), have numerous integral roles in all CNS functions. They are essential for synaptic transmission and support neurons by providing metabolic substrates, secreting growth factors and regulating extracellular concentrations of ions and neurotransmitters. Astrocytes respond to CNS insults through reactive astrogliosis, in which they go through many functional and molecular changes. In neuroinflammatory conditions reactive astrocytes exert both beneficial and detrimental functions, depending on the context and heterogeneity of astrocytic populations. In this review we profile astrocytic diversity in the context of neuroinflammation; with a specific focus on multiple sclerosis (MS) and its best-described animal model experimental autoimmune encephalomyelitis (EAE). We characterize two main subtypes, protoplasmic and fibrous astrocytes and describe the role of intermediate filaments in the physiology and pathology of these cells. Additionally, we outline a variety of markers that are emerging as important in investigating astrocytic biology in both physiological conditions and neuroinflammation.
T2  - Histology and Histopathology
T1  - Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation
IS  - 3
VL  - 36
DO  - 10.14670/HH-18-284
SP  - 267
EP  - 290
ER  - 

@article{
author = "Božić, Iva and Savić, Danijela and Lavrnja, Irena",
year = "2021",
abstract = "Astrocytes, the most abundant glial cells in the central nervous system (CNS), have numerous integral roles in all CNS functions. They are essential for synaptic transmission and support neurons by providing metabolic substrates, secreting growth factors and regulating extracellular concentrations of ions and neurotransmitters. Astrocytes respond to CNS insults through reactive astrogliosis, in which they go through many functional and molecular changes. In neuroinflammatory conditions reactive astrocytes exert both beneficial and detrimental functions, depending on the context and heterogeneity of astrocytic populations. In this review we profile astrocytic diversity in the context of neuroinflammation; with a specific focus on multiple sclerosis (MS) and its best-described animal model experimental autoimmune encephalomyelitis (EAE). We characterize two main subtypes, protoplasmic and fibrous astrocytes and describe the role of intermediate filaments in the physiology and pathology of these cells. Additionally, we outline a variety of markers that are emerging as important in investigating astrocytic biology in both physiological conditions and neuroinflammation.",
journal = "Histology and Histopathology",
title = "Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation",
number = "3",
volume = "36",
doi = "10.14670/HH-18-284",
pages = "267-290"
}

Božić, I., Savić, D.,& Lavrnja, I.. (2021). Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation. in Histology and Histopathology, 36(3), 267-290.
https://doi.org/10.14670/HH-18-284

Božić I, Savić D, Lavrnja I. Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation. in Histology and Histopathology. 2021;36(3):267-290.
doi:10.14670/HH-18-284 .

Božić, Iva, Savić, Danijela, Lavrnja, Irena, "Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation" in Histology and Histopathology, 36, no. 3 (2021):267-290,
https://doi.org/10.14670/HH-18-284 . .