TY  - JOUR
AU  - Vuletić, Ana
AU  - Konjević, Gordana
AU  - Milanović, Desanka
AU  - Ruždijić, Sabera
AU  - Jurisić, Vladimir
PY  - 2010
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/1350
AB  - Retinoic acid (RA), similar to specific growth factors, can induce differentiation of proliferating promyelocytic precursors into terminally differentiated granulocytes, although little is known about effects of its 13-cis isomer on promyelocytic leukemia (PML). In this study we demonstrate that 13-cis-RA has a dose and time-dependant antiproliferative effect on HL-60 PML cell line, that it induces cell accumulation in resting G0/G1 phase of the cell cycle followed by an increase in CD11b granulocyte differentiation antigen expression. The obtained increase in the percentage of HL-60 cells in G0/G1 phase and complementary decrease in S phase of the cell cycle are accompanied by a decrease in the expression of cell cycle regulatory molecule cyclin B1. We also show the induction of interferon regulatory factor-I (IRF- I) transcription that can, also, to some extent contribute to the antiproliferative effect of l 3-cis-RA. Furthermore, down-regulation of BcI-2 protein expression in I 3-cis-RA treated HL-60 cells may contribute to sensitivity to apoptosis of growth arrested HL-60 promyelocytic cells.
T2  - Pathology & Oncology Research
T1  - Antiproliferative Effect of 13-cis-Retinoic Acid is Associated with Granulocyte Differentiation and Decrease in Cyclin B1 and Bcl-2 Protein Levels in G0/G1 Arrested HL-60 Cells
IS  - 3
VL  - 16
DO  - 10.1007/s12253-009-9241-2
SP  - 393
EP  - 401
ER  - 

@article{
author = "Vuletić, Ana and Konjević, Gordana and Milanović, Desanka and Ruždijić, Sabera and Jurisić, Vladimir",
year = "2010",
abstract = "Retinoic acid (RA), similar to specific growth factors, can induce differentiation of proliferating promyelocytic precursors into terminally differentiated granulocytes, although little is known about effects of its 13-cis isomer on promyelocytic leukemia (PML). In this study we demonstrate that 13-cis-RA has a dose and time-dependant antiproliferative effect on HL-60 PML cell line, that it induces cell accumulation in resting G0/G1 phase of the cell cycle followed by an increase in CD11b granulocyte differentiation antigen expression. The obtained increase in the percentage of HL-60 cells in G0/G1 phase and complementary decrease in S phase of the cell cycle are accompanied by a decrease in the expression of cell cycle regulatory molecule cyclin B1. We also show the induction of interferon regulatory factor-I (IRF- I) transcription that can, also, to some extent contribute to the antiproliferative effect of l 3-cis-RA. Furthermore, down-regulation of BcI-2 protein expression in I 3-cis-RA treated HL-60 cells may contribute to sensitivity to apoptosis of growth arrested HL-60 promyelocytic cells.",
journal = "Pathology & Oncology Research",
title = "Antiproliferative Effect of 13-cis-Retinoic Acid is Associated with Granulocyte Differentiation and Decrease in Cyclin B1 and Bcl-2 Protein Levels in G0/G1 Arrested HL-60 Cells",
number = "3",
volume = "16",
doi = "10.1007/s12253-009-9241-2",
pages = "393-401"
}

Vuletić, A., Konjević, G., Milanović, D., Ruždijić, S.,& Jurisić, V.. (2010). Antiproliferative Effect of 13-cis-Retinoic Acid is Associated with Granulocyte Differentiation and Decrease in Cyclin B1 and Bcl-2 Protein Levels in G0/G1 Arrested HL-60 Cells. in Pathology & Oncology Research, 16(3), 393-401.
https://doi.org/10.1007/s12253-009-9241-2

Vuletić A, Konjević G, Milanović D, Ruždijić S, Jurisić V. Antiproliferative Effect of 13-cis-Retinoic Acid is Associated with Granulocyte Differentiation and Decrease in Cyclin B1 and Bcl-2 Protein Levels in G0/G1 Arrested HL-60 Cells. in Pathology & Oncology Research. 2010;16(3):393-401.
doi:10.1007/s12253-009-9241-2 .

Vuletić, Ana, Konjević, Gordana, Milanović, Desanka, Ruždijić, Sabera, Jurisić, Vladimir, "Antiproliferative Effect of 13-cis-Retinoic Acid is Associated with Granulocyte Differentiation and Decrease in Cyclin B1 and Bcl-2 Protein Levels in G0/G1 Arrested HL-60 Cells" in Pathology & Oncology Research, 16, no. 3 (2010):393-401,
https://doi.org/10.1007/s12253-009-9241-2 . .