TY  - JOUR
AU  - Bjelobaba, Ivana
AU  - Janjić, Marija
AU  - Prévide, Rafael Maso
AU  - Abebe, Daniel
AU  - Kucka, Marek
AU  - Stojilković, Stanko S.
PY  - 2019
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2019.00248/full
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3363
AB  - Cell-matrix interactions play important roles in pituitary development, physiology, and pathogenesis. In other tissues, a family of non-collagenous proteins, termed SIBLINGs, are known to contribute to cell-matrix interactions. Anterior pituitary gland expresses two SIBLING genes, Dmp1 (dentin matrix protein-1) and Spp1 (secreted phosphoprotein-1) encoding DMP1 and osteopontin proteins, respectively, but their expression pattern and roles in pituitary functions have not been clarified. Here we provide novel evidence supporting the conclusion that Spp1/osteopontin, like Dmp1/DMP1, are expressed in gonadotrophs in a sex- and age-specific manner. Other anterior pituitary cell types do not express these genes. In contrast to Dmp1, Spp1 expression is higher in males; in females, the expression reaches the peak during the diestrus phase of estrous cycle. In further contrast to Dmp1 and marker genes for gonadotrophs, the expression of Spp1 is not regulated by gonadotropin-releasing hormone in vivo and in vitro. However, Spp1 expression increases progressively after pituitary cell dispersion in both female and male cultures. We may speculate that gonadotrophs signal to other pituitary cell types about changes in the structure of pituitary cell-matrix network by osteopontin, a function consistent with the role of this secretory protein in postnatal tissue remodeling, extracellular matrix reorganization after injury, and tumorigenesis.
PB  - Frontiers Media S.A.
T2  - Frontiers in Endocrinology
T1  - Distinct Expression Patterns of Osteopontin and Dentin Matrix Protein 1 Genes in Pituitary Gonadotrophs
IS  - MAR
VL  - 10
VL  - 10.3389/fendo.2019.00248
DO  - 10.3389/fendo.2019.00248
SP  - 248
ER  - 

@article{
author = "Bjelobaba, Ivana and Janjić, Marija and Prévide, Rafael Maso and Abebe, Daniel and Kucka, Marek and Stojilković, Stanko S.",
year = "2019",
abstract = "Cell-matrix interactions play important roles in pituitary development, physiology, and pathogenesis. In other tissues, a family of non-collagenous proteins, termed SIBLINGs, are known to contribute to cell-matrix interactions. Anterior pituitary gland expresses two SIBLING genes, Dmp1 (dentin matrix protein-1) and Spp1 (secreted phosphoprotein-1) encoding DMP1 and osteopontin proteins, respectively, but their expression pattern and roles in pituitary functions have not been clarified. Here we provide novel evidence supporting the conclusion that Spp1/osteopontin, like Dmp1/DMP1, are expressed in gonadotrophs in a sex- and age-specific manner. Other anterior pituitary cell types do not express these genes. In contrast to Dmp1, Spp1 expression is higher in males; in females, the expression reaches the peak during the diestrus phase of estrous cycle. In further contrast to Dmp1 and marker genes for gonadotrophs, the expression of Spp1 is not regulated by gonadotropin-releasing hormone in vivo and in vitro. However, Spp1 expression increases progressively after pituitary cell dispersion in both female and male cultures. We may speculate that gonadotrophs signal to other pituitary cell types about changes in the structure of pituitary cell-matrix network by osteopontin, a function consistent with the role of this secretory protein in postnatal tissue remodeling, extracellular matrix reorganization after injury, and tumorigenesis.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Endocrinology",
title = "Distinct Expression Patterns of Osteopontin and Dentin Matrix Protein 1 Genes in Pituitary Gonadotrophs",
number = "MAR",
volume = "10, 10.3389/fendo.2019.00248",
doi = "10.3389/fendo.2019.00248",
pages = "248"
}

Bjelobaba, I., Janjić, M., Prévide, R. M., Abebe, D., Kucka, M.,& Stojilković, S. S.. (2019). Distinct Expression Patterns of Osteopontin and Dentin Matrix Protein 1 Genes in Pituitary Gonadotrophs. in Frontiers in Endocrinology
Frontiers Media S.A.., 10(MAR), 248.
https://doi.org/10.3389/fendo.2019.00248

Bjelobaba I, Janjić M, Prévide RM, Abebe D, Kucka M, Stojilković SS. Distinct Expression Patterns of Osteopontin and Dentin Matrix Protein 1 Genes in Pituitary Gonadotrophs. in Frontiers in Endocrinology. 2019;10(MAR):248.
doi:10.3389/fendo.2019.00248 .

Bjelobaba, Ivana, Janjić, Marija, Prévide, Rafael Maso, Abebe, Daniel, Kucka, Marek, Stojilković, Stanko S., "Distinct Expression Patterns of Osteopontin and Dentin Matrix Protein 1 Genes in Pituitary Gonadotrophs" in Frontiers in Endocrinology, 10, no. MAR (2019):248,
https://doi.org/10.3389/fendo.2019.00248 . .