TY  - JOUR
AU  - Matias, Diogo
AU  - Nicolai, Marisa
AU  - Saraiva, Lucília
AU  - Pinheiro, Rute
AU  - Faustino, Célia
AU  - Diaz Lanza, Ana
AU  - Pinto Reis, Catarina
AU  - Stanković, Tijana
AU  - Dinić, Jelena
AU  - Pešić, Milica
AU  - Rijo, Patrícia
PY  - 2019
UR  - http://pubs.acs.org/doi/10.1021/acsomega.9b00512
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3349
AB  - Cytotoxicity screenings have identified Plectranthus plants as potential sources of antitumor lead compounds. In this work, several extracts from Plectranthus madagascariensis were prepared using different solvents (acetone, methanol, and supercritical CO2) and extraction techniques (maceration, ultrasound-assisted, and supercritical fluid extraction), and their chemical composition was detailed using high-performance liquid chromatography with a diode array detector. The cytotoxic activity of the major compounds identified, namely, rosmarinic acid (1) and abietane diterpenes 7α,6β-dihydroxyroyleanone (2), 7α-formyloxy-6β-hydroxyroyleanone (3), 7α-acetoxy-6β-hydroxyroyleanone (4), and coleon U (5), was evaluated in a battery of human cancer cell lines, including breast (MDA-MB-231, MCF-7), colon (HCT116), and lung (NCI-H460, NCI-H460/R) cancer, and also in healthy lung (MCR-5) cells. Royleanone (3) was isolated for the first time from P. madagascariensis, and its full spectroscopic characterization (proto...
T2  - ACS Omega
T1  - Cytotoxic Activity of Royleanone Diterpenes from <i>Plectranthus madagascariensis</i> Benth
IS  - 5
VL  - 4
DO  - 10.1021/acsomega.9b00512
SP  - 8094
EP  - 8103
ER  - 

@article{
author = "Matias, Diogo and Nicolai, Marisa and Saraiva, Lucília and Pinheiro, Rute and Faustino, Célia and Diaz Lanza, Ana and Pinto Reis, Catarina and Stanković, Tijana and Dinić, Jelena and Pešić, Milica and Rijo, Patrícia",
year = "2019",
abstract = "Cytotoxicity screenings have identified Plectranthus plants as potential sources of antitumor lead compounds. In this work, several extracts from Plectranthus madagascariensis were prepared using different solvents (acetone, methanol, and supercritical CO2) and extraction techniques (maceration, ultrasound-assisted, and supercritical fluid extraction), and their chemical composition was detailed using high-performance liquid chromatography with a diode array detector. The cytotoxic activity of the major compounds identified, namely, rosmarinic acid (1) and abietane diterpenes 7α,6β-dihydroxyroyleanone (2), 7α-formyloxy-6β-hydroxyroyleanone (3), 7α-acetoxy-6β-hydroxyroyleanone (4), and coleon U (5), was evaluated in a battery of human cancer cell lines, including breast (MDA-MB-231, MCF-7), colon (HCT116), and lung (NCI-H460, NCI-H460/R) cancer, and also in healthy lung (MCR-5) cells. Royleanone (3) was isolated for the first time from P. madagascariensis, and its full spectroscopic characterization (proto...",
journal = "ACS Omega",
title = "Cytotoxic Activity of Royleanone Diterpenes from <i>Plectranthus madagascariensis</i> Benth",
number = "5",
volume = "4",
doi = "10.1021/acsomega.9b00512",
pages = "8094-8103"
}

Matias, D., Nicolai, M., Saraiva, L., Pinheiro, R., Faustino, C., Diaz Lanza, A., Pinto Reis, C., Stanković, T., Dinić, J., Pešić, M.,& Rijo, P.. (2019). Cytotoxic Activity of Royleanone Diterpenes from <i>Plectranthus madagascariensis</i> Benth. in ACS Omega, 4(5), 8094-8103.
https://doi.org/10.1021/acsomega.9b00512

Matias D, Nicolai M, Saraiva L, Pinheiro R, Faustino C, Diaz Lanza A, Pinto Reis C, Stanković T, Dinić J, Pešić M, Rijo P. Cytotoxic Activity of Royleanone Diterpenes from <i>Plectranthus madagascariensis</i> Benth. in ACS Omega. 2019;4(5):8094-8103.
doi:10.1021/acsomega.9b00512 .

Matias, Diogo, Nicolai, Marisa, Saraiva, Lucília, Pinheiro, Rute, Faustino, Célia, Diaz Lanza, Ana, Pinto Reis, Catarina, Stanković, Tijana, Dinić, Jelena, Pešić, Milica, Rijo, Patrícia, "Cytotoxic Activity of Royleanone Diterpenes from <i>Plectranthus madagascariensis</i> Benth" in ACS Omega, 4, no. 5 (2019):8094-8103,
https://doi.org/10.1021/acsomega.9b00512 . .