TY  - JOUR
AU  - Pešić, Vesna
AU  - Veskov, Rosica
AU  - Petković, Branka
AU  - Rakić, Ljubisav
AU  - Stojiljković, Mirjana
PY  - 2003
UR  - https://www.sciencedirect.com/science/article/abs/pii/S0197458002002324?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3812
AB  - Changes in locomotor and stereotypic activities induced by an i.p. injection of either (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cycloheptan-5,10- imine maleate (dizocilpine or MK-801; 0.3 mg/kg) or D-amphetamine sulfate (AMPH; 1.5 mg/kg) were studied in male Mill Hill hooded rats of different age. The following age groups of animals were considered: 28-30 postnatal day (PND)-old rats (peripubertal), 48-50 PND-old (pubertal), 3-month-old (adults), 12-month-old (middle-aged) and 24-month-old (aged). The motor response was measured by an automated animal activity measuring system. The obtained results showed that: (1) in contrast to AMPH, MK-801 induced more pronounced increases of both locomotor and stereotypic activities in peripubertal and pubertal than in adult and aged rats; (2) AMPH induced the same locomotor and stereotypic activity increase in pubertal, adult and middle-aged rats; (3) both AMPH and MK-801 led to a senescence-related decrease of motor activity. These data suggest that the balance of the glutamatergic and dopaminergic systems changes during aging. Such a change is important in understanding schizophrenia and the motor system decline observed in the later stages of life.
PB  - Elsevier Science Inc
T2  - Neurobiology of Aging
T1  - Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats
IS  - 5
VL  - 24
DO  - 10.1016/S0197-4580(02)00232-4
SP  - 715
EP  - 723
ER  - 

@article{
author = "Pešić, Vesna and Veskov, Rosica and Petković, Branka and Rakić, Ljubisav and Stojiljković, Mirjana",
year = "2003",
abstract = "Changes in locomotor and stereotypic activities induced by an i.p. injection of either (+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cycloheptan-5,10- imine maleate (dizocilpine or MK-801; 0.3 mg/kg) or D-amphetamine sulfate (AMPH; 1.5 mg/kg) were studied in male Mill Hill hooded rats of different age. The following age groups of animals were considered: 28-30 postnatal day (PND)-old rats (peripubertal), 48-50 PND-old (pubertal), 3-month-old (adults), 12-month-old (middle-aged) and 24-month-old (aged). The motor response was measured by an automated animal activity measuring system. The obtained results showed that: (1) in contrast to AMPH, MK-801 induced more pronounced increases of both locomotor and stereotypic activities in peripubertal and pubertal than in adult and aged rats; (2) AMPH induced the same locomotor and stereotypic activity increase in pubertal, adult and middle-aged rats; (3) both AMPH and MK-801 led to a senescence-related decrease of motor activity. These data suggest that the balance of the glutamatergic and dopaminergic systems changes during aging. Such a change is important in understanding schizophrenia and the motor system decline observed in the later stages of life.",
publisher = "Elsevier Science Inc",
journal = "Neurobiology of Aging",
title = "Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats",
number = "5",
volume = "24",
doi = "10.1016/S0197-4580(02)00232-4",
pages = "715-723"
}

Pešić, V., Veskov, R., Petković, B., Rakić, L.,& Stojiljković, M.. (2003). Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats. in Neurobiology of Aging
Elsevier Science Inc., 24(5), 715-723.
https://doi.org/10.1016/S0197-4580(02)00232-4

Pešić V, Veskov R, Petković B, Rakić L, Stojiljković M. Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats. in Neurobiology of Aging. 2003;24(5):715-723.
doi:10.1016/S0197-4580(02)00232-4 .

Pešić, Vesna, Veskov, Rosica, Petković, Branka, Rakić, Ljubisav, Stojiljković, Mirjana, "Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats" in Neurobiology of Aging, 24, no. 5 (2003):715-723,
https://doi.org/10.1016/S0197-4580(02)00232-4 . .