TY  - JOUR
AU  - Ilić, Đorđe
AU  - Ilić, Aleksandra
AU  - Jakovljević, Branislava
AU  - Džigurski, Jelisaveta
AU  - Dragić, Nataša
AU  - Simić, Svetlana
AU  - Petković, Branka
AU  - Sekulić, Slobodan
PY  - 2021
UR  - https://www.arccjournals.com/journal/indian-journal-of-animal-research/B-1319
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4428
AB  - A review was conducted using PubMed/MEDLINE (published articles) as well as World Wide Web (video material) to determine the frequency of anterior and posterior presentation of the elephant at birth. Of 46 identified cases, 12 were in anterior and 34 in posterior presentation. The Fisher exact test (p= 0.682) did not show a statistically significant difference in the distribution of presentations between the Loxodonta africana (2 anterior and 10 posterior presentation) and Elephas maximus (10 anterior and 24 posterior presentation). The ratio between anterior and posterior presentation 6:29 (18.51% versus 81.49%) at birth without knowing dystocia, is significantly different from the distribution anterior and posterior presentation 6:3 (66.7% versus 33.3%) in cases with dystocia (Fisher exact test p = 0.012). Obtained data shows that posterior presentation at birth in elephants is more often present than anterior, while anterior presentation is more often associated with dystocia.
PB  - Karnal : Agricultural Research Communication Centre
T2  - Indian Journal of Animal Research
T1  - The Incidence of Anterior and Posterior Presentation at Birth in Asian (Elephas maximus) and African Elephants (Loxodonta africana): A Review Study
IS  - 8
VL  - 55
DO  - 10.18805/IJAR.B-1319
SP  - 863
EP  - 866
ER  - 

@article{
author = "Ilić, Đorđe and Ilić, Aleksandra and Jakovljević, Branislava and Džigurski, Jelisaveta and Dragić, Nataša and Simić, Svetlana and Petković, Branka and Sekulić, Slobodan",
year = "2021",
abstract = "A review was conducted using PubMed/MEDLINE (published articles) as well as World Wide Web (video material) to determine the frequency of anterior and posterior presentation of the elephant at birth. Of 46 identified cases, 12 were in anterior and 34 in posterior presentation. The Fisher exact test (p= 0.682) did not show a statistically significant difference in the distribution of presentations between the Loxodonta africana (2 anterior and 10 posterior presentation) and Elephas maximus (10 anterior and 24 posterior presentation). The ratio between anterior and posterior presentation 6:29 (18.51% versus 81.49%) at birth without knowing dystocia, is significantly different from the distribution anterior and posterior presentation 6:3 (66.7% versus 33.3%) in cases with dystocia (Fisher exact test p = 0.012). Obtained data shows that posterior presentation at birth in elephants is more often present than anterior, while anterior presentation is more often associated with dystocia.",
publisher = "Karnal : Agricultural Research Communication Centre",
journal = "Indian Journal of Animal Research",
title = "The Incidence of Anterior and Posterior Presentation at Birth in Asian (Elephas maximus) and African Elephants (Loxodonta africana): A Review Study",
number = "8",
volume = "55",
doi = "10.18805/IJAR.B-1319",
pages = "863-866"
}

Ilić, Đ., Ilić, A., Jakovljević, B., Džigurski, J., Dragić, N., Simić, S., Petković, B.,& Sekulić, S.. (2021). The Incidence of Anterior and Posterior Presentation at Birth in Asian (Elephas maximus) and African Elephants (Loxodonta africana): A Review Study. in Indian Journal of Animal Research
Karnal : Agricultural Research Communication Centre., 55(8), 863-866.
https://doi.org/10.18805/IJAR.B-1319

Ilić Đ, Ilić A, Jakovljević B, Džigurski J, Dragić N, Simić S, Petković B, Sekulić S. The Incidence of Anterior and Posterior Presentation at Birth in Asian (Elephas maximus) and African Elephants (Loxodonta africana): A Review Study. in Indian Journal of Animal Research. 2021;55(8):863-866.
doi:10.18805/IJAR.B-1319 .

Ilić, Đorđe, Ilić, Aleksandra, Jakovljević, Branislava, Džigurski, Jelisaveta, Dragić, Nataša, Simić, Svetlana, Petković, Branka, Sekulić, Slobodan, "The Incidence of Anterior and Posterior Presentation at Birth in Asian (Elephas maximus) and African Elephants (Loxodonta africana): A Review Study" in Indian Journal of Animal Research, 55, no. 8 (2021):863-866,
https://doi.org/10.18805/IJAR.B-1319 . .

TY  - JOUR
AU  - Čapo, Ivan
AU  - Milenković, Ivan
AU  - Čapo, Nataša
AU  - Stilinović, Nebojša
AU  - Vukmirović, Saša
AU  - Teofilovic, Branislava
AU  - Petković, Branka
AU  - Sekulić, Slobodan
PY  - 2020
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46642000041C
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4102
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/6035
AB  - The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.
PB  - Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses
IS  - 4
VL  - 72
DO  - 10.2298/ABS200619041C
SP  - 473
EP  - 482
ER  - 

@article{
author = "Čapo, Ivan and Milenković, Ivan and Čapo, Nataša and Stilinović, Nebojša and Vukmirović, Saša and Teofilovic, Branislava and Petković, Branka and Sekulić, Slobodan",
year = "2020",
abstract = "The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.",
publisher = "Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses",
number = "4",
volume = "72",
doi = "10.2298/ABS200619041C",
pages = "473-482"
}

Čapo, I., Milenković, I., Čapo, N., Stilinović, N., Vukmirović, S., Teofilovic, B., Petković, B.,& Sekulić, S.. (2020). Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses. in Archives of Biological Sciences
Serbian Biological Society., 72(4), 473-482.
https://doi.org/10.2298/ABS200619041C

Čapo I, Milenković I, Čapo N, Stilinović N, Vukmirović S, Teofilovic B, Petković B, Sekulić S. Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses. in Archives of Biological Sciences. 2020;72(4):473-482.
doi:10.2298/ABS200619041C .

Čapo, Ivan, Milenković, Ivan, Čapo, Nataša, Stilinović, Nebojša, Vukmirović, Saša, Teofilovic, Branislava, Petković, Branka, Sekulić, Slobodan, "Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses" in Archives of Biological Sciences, 72, no. 4 (2020):473-482,
https://doi.org/10.2298/ABS200619041C . .

TY  - JOUR
AU  - Pupovac, Nikolina
AU  - Erić, Mirela
AU  - Sekulić, Slobodan
AU  - Knezi, Nikola
AU  - Vlaški, Angelina
AU  - Hajder, Dragica
AU  - Petković, Branka
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3763
AB  - The carotid canal is located in the petrous part of the temporal bone and transmits the internal carotid artery along with the venous and sympathetic nerve plexus. The shape, location and dimensions of the carotid canal are clinically very important especially in cases of skull base surgery. The aim of this study was to investigate the morphological and morphometric parameters of the external aperture of the carotid canal in Serbian population. The study included 24 dry adult skulls and 36 dry adult temporal bones. Diameters and distances of the external aperture of the carotid canal from various important landmarks of the skull base were measured. The shape of the external carotid canal aperture was also noted. Digital data were processed in the ImageJ software. The average length of the external aperture of the carotid canal in all investigated specimens (skulls and temporal bones) on the right and left sides was 7.31±1.01 mm and 7.71±1.06 mm, respectively. The average width of the external aperture of the carotid canal on the right side was 5.82±0.78 mm while on the left side was 6.20±1.04 mm. The frequency of different shapes of the external aperture of the carotid canal was as follows: round in 45 (53.57 %), oval in 25 (29.76 %), and the rarest was almond shape noted in 13 (15.47 %) cases. There were no statistically significant differences in all measured parameters between genders and body sides. The only statistical significance was found in females between right and left side in relation with length (AP diameter) of the external aperture of the carotid canal. The results of this study will be useful for neurosurgeons to improve different surgical approaches to the petrous part of the internal carotid artery and prevent its complications.
AB  - El conducto carotídeo se encuentra en la parte petrosa del hueso temporal y da paso a la arteria carótida interna junto con el plexo nervioso venoso y simpático. La forma, ubicación y dimensiones del canal carotídeo son clínicamente muy importantes, especialmente en casos de cirugía de la base del cráneo. El objetivo de este estudio fue investigar los parámetros morfológicos y morfométricos de la apertura externa del canal carotídeo en la población serbia. El estudio incluyó 24 cráneos adultoss y 36 huesos temporales adultos secos. Se midieron los diámetros y distancias de la apertura externa desde varios puntos de referencia de la base del cráneo. También se observó la forma de la apertura del canal carotídeo externo. Los datos digitales se procesaron con Software ImageJ. La longitud promedio de la apertura en todos los especímenes investigados (cráneos y huesos temporales) en los lados derecho e izquierdo fue de 7,31 ± 1,01 mm y 7,71 ± 1,06 mm, respectivamente. El ancho promedio de la apertura en el lado derecho fue de 5,82 ± 0,78 mm mientras que en el lado izquierdo fue de 6,20 ± 1,04 mm. La frecuencia de las diferentes formas de la abertura externa fue la siguiente: redonda en 45 (53,57 %), ovalada en 25 (29,76 %), y la más rara fue la forma de almendra observada en 13 (15,47 %) casos. No hubo diferencias estadísticamente significativas en todos los parámetros medidos entre sexos y lados del cuerpo. La única estadística significativa se encontró en las mujeres entre el lado derecho e izquierdo en relación con la longitud (diámetro AP) de la apertura externa del conducto carotídeo. Los resultados de este estudio serán útiles para un mejor enfoque quirúrgico de los neurocirujanos en la parte petrosa de la arteria carótida interna, y advertir posibles complicaciones.
PB  - Chilean Society of Anatomy
T2  - International Journal of Morphology
T1  - Morphological and Morphometric Analysis of the External Aperture of the Carotid Canal in Serbian Population
T1  - Análisis Morfológico y Morfométrico de la Apertura Externa del Canal Carotídeo en la Población Serbia
IS  - 4
VL  - 38
DO  - 10.4067/S0717-95022020000401026
SP  - 1026
EP  - 1031
ER  - 

@article{
author = "Pupovac, Nikolina and Erić, Mirela and Sekulić, Slobodan and Knezi, Nikola and Vlaški, Angelina and Hajder, Dragica and Petković, Branka",
year = "2020",
abstract = "The carotid canal is located in the petrous part of the temporal bone and transmits the internal carotid artery along with the venous and sympathetic nerve plexus. The shape, location and dimensions of the carotid canal are clinically very important especially in cases of skull base surgery. The aim of this study was to investigate the morphological and morphometric parameters of the external aperture of the carotid canal in Serbian population. The study included 24 dry adult skulls and 36 dry adult temporal bones. Diameters and distances of the external aperture of the carotid canal from various important landmarks of the skull base were measured. The shape of the external carotid canal aperture was also noted. Digital data were processed in the ImageJ software. The average length of the external aperture of the carotid canal in all investigated specimens (skulls and temporal bones) on the right and left sides was 7.31±1.01 mm and 7.71±1.06 mm, respectively. The average width of the external aperture of the carotid canal on the right side was 5.82±0.78 mm while on the left side was 6.20±1.04 mm. The frequency of different shapes of the external aperture of the carotid canal was as follows: round in 45 (53.57 %), oval in 25 (29.76 %), and the rarest was almond shape noted in 13 (15.47 %) cases. There were no statistically significant differences in all measured parameters between genders and body sides. The only statistical significance was found in females between right and left side in relation with length (AP diameter) of the external aperture of the carotid canal. The results of this study will be useful for neurosurgeons to improve different surgical approaches to the petrous part of the internal carotid artery and prevent its complications., El conducto carotídeo se encuentra en la parte petrosa del hueso temporal y da paso a la arteria carótida interna junto con el plexo nervioso venoso y simpático. La forma, ubicación y dimensiones del canal carotídeo son clínicamente muy importantes, especialmente en casos de cirugía de la base del cráneo. El objetivo de este estudio fue investigar los parámetros morfológicos y morfométricos de la apertura externa del canal carotídeo en la población serbia. El estudio incluyó 24 cráneos adultoss y 36 huesos temporales adultos secos. Se midieron los diámetros y distancias de la apertura externa desde varios puntos de referencia de la base del cráneo. También se observó la forma de la apertura del canal carotídeo externo. Los datos digitales se procesaron con Software ImageJ. La longitud promedio de la apertura en todos los especímenes investigados (cráneos y huesos temporales) en los lados derecho e izquierdo fue de 7,31 ± 1,01 mm y 7,71 ± 1,06 mm, respectivamente. El ancho promedio de la apertura en el lado derecho fue de 5,82 ± 0,78 mm mientras que en el lado izquierdo fue de 6,20 ± 1,04 mm. La frecuencia de las diferentes formas de la abertura externa fue la siguiente: redonda en 45 (53,57 %), ovalada en 25 (29,76 %), y la más rara fue la forma de almendra observada en 13 (15,47 %) casos. No hubo diferencias estadísticamente significativas en todos los parámetros medidos entre sexos y lados del cuerpo. La única estadística significativa se encontró en las mujeres entre el lado derecho e izquierdo en relación con la longitud (diámetro AP) de la apertura externa del conducto carotídeo. Los resultados de este estudio serán útiles para un mejor enfoque quirúrgico de los neurocirujanos en la parte petrosa de la arteria carótida interna, y advertir posibles complicaciones.",
publisher = "Chilean Society of Anatomy",
journal = "International Journal of Morphology",
title = "Morphological and Morphometric Analysis of the External Aperture of the Carotid Canal in Serbian Population, Análisis Morfológico y Morfométrico de la Apertura Externa del Canal Carotídeo en la Población Serbia",
number = "4",
volume = "38",
doi = "10.4067/S0717-95022020000401026",
pages = "1026-1031"
}

Pupovac, N., Erić, M., Sekulić, S., Knezi, N., Vlaški, A., Hajder, D.,& Petković, B.. (2020). Morphological and Morphometric Analysis of the External Aperture of the Carotid Canal in Serbian Population. in International Journal of Morphology
Chilean Society of Anatomy., 38(4), 1026-1031.
https://doi.org/10.4067/S0717-95022020000401026

Pupovac N, Erić M, Sekulić S, Knezi N, Vlaški A, Hajder D, Petković B. Morphological and Morphometric Analysis of the External Aperture of the Carotid Canal in Serbian Population. in International Journal of Morphology. 2020;38(4):1026-1031.
doi:10.4067/S0717-95022020000401026 .

Pupovac, Nikolina, Erić, Mirela, Sekulić, Slobodan, Knezi, Nikola, Vlaški, Angelina, Hajder, Dragica, Petković, Branka, "Morphological and Morphometric Analysis of the External Aperture of the Carotid Canal in Serbian Population" in International Journal of Morphology, 38, no. 4 (2020):1026-1031,
https://doi.org/10.4067/S0717-95022020000401026 . .

TY  - JOUR
AU  - Drljača, Jovana
AU  - Vejnović, Ana-Marija
AU  - Miljković, Dejan
AU  - Popović, Milan
AU  - Rakić, Dušica
AU  - Sekulić, Slobodan
AU  - Čapo, Ivan
AU  - Petković, Branka
PY  - 2020
UR  - http://www.serbiosoc.org.rs/arch/index.php/abs/article/view/4473
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3655
AB  - The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress.
T2  - Archives of Biological Sciences
T1  - Changes in mouse thymus after exposure to tube-restraint stress
IS  - 1
VL  - 72
DO  - 10.2298/abs190716060d
SP  - 5
EP  - 11
ER  - 

@article{
author = "Drljača, Jovana and Vejnović, Ana-Marija and Miljković, Dejan and Popović, Milan and Rakić, Dušica and Sekulić, Slobodan and Čapo, Ivan and Petković, Branka",
year = "2020",
abstract = "The thymus is the primary lymphoid organ involved in the regulation of the immune and endocrine systems. It is particularly sensitive to various types of stress, which induce its atrophy. This study deals with the effect of repeated restraint stress on the weight, proliferation and apoptosis of the thymus in mice. During restraint, the animals were placed in 50-mL conical plastic tubes for 2 h every day for either 10 or 20 consecutive days. A significant reduction in thymus weight along with decreased cellularity and pronounced atrophy of the cortical part of the thymus was observed in animals exposed to repeated tube-restraint stress for 10 and 20 consecutive days. The observed changes in the thymus were the same, regardless of the number of days of exposure to stress. These findings provide a more comprehensive view of repeated tube-restraint, with special emphasis on its duration on stress-induced thymus atrophy. The presented findings could serve as a basis for further studies aimed at identifying the mechanisms responsible for the adaptive response of the thymus after repeated exposure to stress.",
journal = "Archives of Biological Sciences",
title = "Changes in mouse thymus after exposure to tube-restraint stress",
number = "1",
volume = "72",
doi = "10.2298/abs190716060d",
pages = "5-11"
}

Drljača, J., Vejnović, A., Miljković, D., Popović, M., Rakić, D., Sekulić, S., Čapo, I.,& Petković, B.. (2020). Changes in mouse thymus after exposure to tube-restraint stress. in Archives of Biological Sciences, 72(1), 5-11.
https://doi.org/10.2298/abs190716060d

Drljača J, Vejnović A, Miljković D, Popović M, Rakić D, Sekulić S, Čapo I, Petković B. Changes in mouse thymus after exposure to tube-restraint stress. in Archives of Biological Sciences. 2020;72(1):5-11.
doi:10.2298/abs190716060d .

Drljača, Jovana, Vejnović, Ana-Marija, Miljković, Dejan, Popović, Milan, Rakić, Dušica, Sekulić, Slobodan, Čapo, Ivan, Petković, Branka, "Changes in mouse thymus after exposure to tube-restraint stress" in Archives of Biological Sciences, 72, no. 1 (2020):5-11,
https://doi.org/10.2298/abs190716060d . .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Petković, Branka
PY  - 2019
UR  - https://www.tandfonline.com/doi/full/10.1080/01443615.2018.1557612
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3324
T2  - Journal of Obstetrics and Gynaecology
T1  - First confirmation of the hypothesis that polyhydramnios causes bone maldevelopment
IS  - 6
VL  - 39
DO  - 10.1080/01443615.2018.1557612
SP  - 879
ER  - 

@article{
author = "Sekulić, Slobodan and Petković, Branka",
year = "2019",
journal = "Journal of Obstetrics and Gynaecology",
title = "First confirmation of the hypothesis that polyhydramnios causes bone maldevelopment",
number = "6",
volume = "39",
doi = "10.1080/01443615.2018.1557612",
pages = "879"
}

Sekulić, S.,& Petković, B.. (2019). First confirmation of the hypothesis that polyhydramnios causes bone maldevelopment. in Journal of Obstetrics and Gynaecology, 39(6), 879.
https://doi.org/10.1080/01443615.2018.1557612

Sekulić S, Petković B. First confirmation of the hypothesis that polyhydramnios causes bone maldevelopment. in Journal of Obstetrics and Gynaecology. 2019;39(6):879.
doi:10.1080/01443615.2018.1557612 .

Sekulić, Slobodan, Petković, Branka, "First confirmation of the hypothesis that polyhydramnios causes bone maldevelopment" in Journal of Obstetrics and Gynaecology, 39, no. 6 (2019):879,
https://doi.org/10.1080/01443615.2018.1557612 . .

TY  - JOUR
AU  - Keković, Goran
AU  - Sekulić, S.
PY  - 2019
UR  - http://link.springer.com/10.1007/s11062-019-09783-y
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3368
AB  - We investigated change point detection (CPD) in time series composed of harmonic functions driven by Gaussian noise (in EEGs, in particular) and proposed a method of moving average filters in conjunction with wavelet transform. Numerical simulations showed that CPD runs over 90% within the frequency band <40 Hz. This means that detection of structural change points is almost guaranteed in the respective cases. The mean absolute error (MAE) as a measure of performance of the method was below 5%. The method is rather robust against noise. It has been demonstrated that CPD is possible at the noise amplitude exceeding 25% of the amplitude of harmonic functions. In application of the proposed method on the signals, CPD appeared in 74% of the analyzed EEGs.
T2  - Neurophysiology
T2  - Neurophysiology
T1  - Detection of Change Points in Time Series with Moving Average Filters and Wavelet Transform: Application to EEG Signals
IS  - 1
VL  - 51
DO  - 10.1007/s11062-019-09783-y
SP  - 2
EP  - 8
ER  - 

@article{
author = "Keković, Goran and Sekulić, S.",
year = "2019",
abstract = "We investigated change point detection (CPD) in time series composed of harmonic functions driven by Gaussian noise (in EEGs, in particular) and proposed a method of moving average filters in conjunction with wavelet transform. Numerical simulations showed that CPD runs over 90% within the frequency band <40 Hz. This means that detection of structural change points is almost guaranteed in the respective cases. The mean absolute error (MAE) as a measure of performance of the method was below 5%. The method is rather robust against noise. It has been demonstrated that CPD is possible at the noise amplitude exceeding 25% of the amplitude of harmonic functions. In application of the proposed method on the signals, CPD appeared in 74% of the analyzed EEGs.",
journal = "Neurophysiology, Neurophysiology",
title = "Detection of Change Points in Time Series with Moving Average Filters and Wavelet Transform: Application to EEG Signals",
number = "1",
volume = "51",
doi = "10.1007/s11062-019-09783-y",
pages = "2-8"
}

Keković, G.,& Sekulić, S.. (2019). Detection of Change Points in Time Series with Moving Average Filters and Wavelet Transform: Application to EEG Signals. in Neurophysiology, 51(1), 2-8.
https://doi.org/10.1007/s11062-019-09783-y

Keković G, Sekulić S. Detection of Change Points in Time Series with Moving Average Filters and Wavelet Transform: Application to EEG Signals. in Neurophysiology. 2019;51(1):2-8.
doi:10.1007/s11062-019-09783-y .

Keković, Goran, Sekulić, S., "Detection of Change Points in Time Series with Moving Average Filters and Wavelet Transform: Application to EEG Signals" in Neurophysiology, 51, no. 1 (2019):2-8,
https://doi.org/10.1007/s11062-019-09783-y . .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Stojadinović, Gordana
AU  - Petković, Branka
PY  - 2017
UR  - http://www.doiserbia.nb.rs/issue.aspx?issueid=3008
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3773
AB  - Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2–3 months old rats weighing 200 – 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity.
AB  - Uvod. U eksperimentima je uporedo registrovana elektrokortikalna aktivnost parijetalne kore velikog mozga, kao i aktivnost kore malog mozga. Cilj je da se uporedi njihova spontana aktivnost jer se registrovanje vrši u anesteziji. Materijal i metode. U istraživanju smo koristili pacove starosti 2 - 3 meseca, telesne mase 200 - 350 g. Formirane su dve grupe pacova sa istim karakteristikama. Kod prve grupe, koju cinilo je 15 pacova (kontrolna grupa) ispitivanje je rađeno u anesteziji, zabeležene su promene spektralne snage u skladu sa obimom frekvencije. Druga grupa od 30 pacova je ispitivana pod istim eksperimentalnim uslovima, ali su pacovi tretirani rastvorom aluminijum hlorid heksahidrata, ili 1.5 % rastvorom aluminijum hlorid heksahidrata per os. Diskusija. Promena spontane aktivnosti malog mozga u uslovima intoksikacije aluminijumom je poređena sa kontrolnim vrednostima. Pokazano je da lezija i neurotoksičnost u uslovima stabilne anestezije dovode do desinhronizacije aktivnosti malog mozga. Ovo je opisano promenom fraktalne dimenzije elektrokortikalne aktivnosti. Pretpostavka je da se inhibicija izazvana anestetikom kompenzuje u uslovima intoksikacije aluminijumom. Zaključak. Mali mozak ima ulogu u kompenzaciji putem promene spontane aktivnosti. Ovakav odgovor podrazumeva povećanje vrednosti fraktalne dimenzije elektrokortikalne aktivnosti malog mozga koja je u uslovima neurotoksičnosti smanjena.
PB  - Društvo lekara Vojvodine Srpskog lekarskog društva
T2  - Medical Review
T1  - Spontaneous cerebellar activity and its role in neurotoxicity
T1  - Spontana aktivnost malog mozga i njegova uloga u neurotoksičnosti
IS  - 9-10
VL  - 70
DO  - 10.2298/MPNS1710283M
SP  - 283
EP  - 289
ER  - 

@article{
author = "Martać, Ljiljana and Stojadinović, Gordana and Petković, Branka",
year = "2017",
abstract = "Introduction. In performed experiments, the parietal electrocortical activity of the cerebral cortex and the activity of the cerebellar cortex were simultaneously recorded. The main purpose was to compare their spontaneous activity, as the recording was conducted during anesthesia. Material and Methods. We used 2–3 months old rats weighing 200 – 350 g. Two groups of rats with same characteristics were made. The first group of 15 rats (control group) was recorded under anesthesia and there was a change in spectral power in accordance with frequency ranges. The second group of 30 rats was recorded under the same experimental conditions, but the rats were treated intraperitoneally by aluminium chloride hexahydrate solution or with 1.5% solution of aluminium chloride hexahydrate per os. Discussion. Changes in spontaneous activity of the cerebellum during aluminium intoxication were compared with control values. It was shown that lesion and neurotoxicity during stable anesthesia led to desynchronization of the cerebellar activity. This is described by the change in fractal dimension of cerebellar electrocortical activity. The assumption is that the inhibition caused by anesthetic is compensated during aluminium intoxication. Conclusion. The cerebellum plays a role in compensation through changes in spontaneous activity. This response involves an increase in the value of fractal dimension of cerebellar electrocortical activity which is reduced in neurotoxicity., Uvod. U eksperimentima je uporedo registrovana elektrokortikalna aktivnost parijetalne kore velikog mozga, kao i aktivnost kore malog mozga. Cilj je da se uporedi njihova spontana aktivnost jer se registrovanje vrši u anesteziji. Materijal i metode. U istraživanju smo koristili pacove starosti 2 - 3 meseca, telesne mase 200 - 350 g. Formirane su dve grupe pacova sa istim karakteristikama. Kod prve grupe, koju cinilo je 15 pacova (kontrolna grupa) ispitivanje je rađeno u anesteziji, zabeležene su promene spektralne snage u skladu sa obimom frekvencije. Druga grupa od 30 pacova je ispitivana pod istim eksperimentalnim uslovima, ali su pacovi tretirani rastvorom aluminijum hlorid heksahidrata, ili 1.5 % rastvorom aluminijum hlorid heksahidrata per os. Diskusija. Promena spontane aktivnosti malog mozga u uslovima intoksikacije aluminijumom je poređena sa kontrolnim vrednostima. Pokazano je da lezija i neurotoksičnost u uslovima stabilne anestezije dovode do desinhronizacije aktivnosti malog mozga. Ovo je opisano promenom fraktalne dimenzije elektrokortikalne aktivnosti. Pretpostavka je da se inhibicija izazvana anestetikom kompenzuje u uslovima intoksikacije aluminijumom. Zaključak. Mali mozak ima ulogu u kompenzaciji putem promene spontane aktivnosti. Ovakav odgovor podrazumeva povećanje vrednosti fraktalne dimenzije elektrokortikalne aktivnosti malog mozga koja je u uslovima neurotoksičnosti smanjena.",
publisher = "Društvo lekara Vojvodine Srpskog lekarskog društva",
journal = "Medical Review",
title = "Spontaneous cerebellar activity and its role in neurotoxicity, Spontana aktivnost malog mozga i njegova uloga u neurotoksičnosti",
number = "9-10",
volume = "70",
doi = "10.2298/MPNS1710283M",
pages = "283-289"
}

Martać, L., Stojadinović, G.,& Petković, B.. (2017). Spontaneous cerebellar activity and its role in neurotoxicity. in Medical Review
Društvo lekara Vojvodine Srpskog lekarskog društva., 70(9-10), 283-289.
https://doi.org/10.2298/MPNS1710283M

Martać L, Stojadinović G, Petković B. Spontaneous cerebellar activity and its role in neurotoxicity. in Medical Review. 2017;70(9-10):283-289.
doi:10.2298/MPNS1710283M .

Martać, Ljiljana, Stojadinović, Gordana, Petković, Branka, "Spontaneous cerebellar activity and its role in neurotoxicity" in Medical Review, 70, no. 9-10 (2017):283-289,
https://doi.org/10.2298/MPNS1710283M . .

TY  - JOUR
AU  - Martać, Ljiljana
AU  - Sekulić, Slobodan
AU  - Cvijanović, Milan
PY  - 2016
UR  - http://www.architalbiol.org/aib/article/view/154118
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2755
AB  - We used electrocortical spectral analysis and fractal methods for assessing the effects of unilateral, single brain injury on cerebellum. Cerebellar electrocortical activity was recorded in control state (before the injury) and after a single brain injury of the cerebellar cortex in anesthetized rats. We noticed that the mean power in gamma high-frequency domain (32-128 Hz) of the cerebellum, was increased after the first brain injury, while after a two-week recovery, it was larger than before the injury. The unilateral brain injury induced a permanent increase of the mild gamma activity in both the left and the right side of cerebellum cortex, but there was no further increase after the lesion was repeated. Our recent electrophysiological study on the cerebellum (Culic et al., 2005) suggested that the mean power spectra of the cerebellar cortical activity in the gamma frequency range might be the indicator of acute single focal brain injury. However, there is insufficient information on the effects of the repeated brain injury on the cerebellar electrocortical activity and morphology. There was no significant difference between the absolute and the relative mean power of the left and the right paravermal cortical activity (before, as well as, after the injury), in each of the animals tested afterwards, but there were differences between the left and the right side of cerebellum in experimental animals. Repeated injury of the cerebellar cortical areas, is strengthened by morphological changes in the cerebellar hemisphere, and shows a decrease in delta and an increase in gamma range.
T2  - Archives Italiennes de Biologie
T1  - Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum
IS  - 4
VL  - 154
DO  - 10.12871/00039829201441
SP  - 118
EP  - 124
ER  - 

@article{
author = "Martać, Ljiljana and Sekulić, Slobodan and Cvijanović, Milan",
year = "2016",
abstract = "We used electrocortical spectral analysis and fractal methods for assessing the effects of unilateral, single brain injury on cerebellum. Cerebellar electrocortical activity was recorded in control state (before the injury) and after a single brain injury of the cerebellar cortex in anesthetized rats. We noticed that the mean power in gamma high-frequency domain (32-128 Hz) of the cerebellum, was increased after the first brain injury, while after a two-week recovery, it was larger than before the injury. The unilateral brain injury induced a permanent increase of the mild gamma activity in both the left and the right side of cerebellum cortex, but there was no further increase after the lesion was repeated. Our recent electrophysiological study on the cerebellum (Culic et al., 2005) suggested that the mean power spectra of the cerebellar cortical activity in the gamma frequency range might be the indicator of acute single focal brain injury. However, there is insufficient information on the effects of the repeated brain injury on the cerebellar electrocortical activity and morphology. There was no significant difference between the absolute and the relative mean power of the left and the right paravermal cortical activity (before, as well as, after the injury), in each of the animals tested afterwards, but there were differences between the left and the right side of cerebellum in experimental animals. Repeated injury of the cerebellar cortical areas, is strengthened by morphological changes in the cerebellar hemisphere, and shows a decrease in delta and an increase in gamma range.",
journal = "Archives Italiennes de Biologie",
title = "Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum",
number = "4",
volume = "154",
doi = "10.12871/00039829201441",
pages = "118-124"
}

Martać, L., Sekulić, S.,& Cvijanović, M.. (2016). Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum. in Archives Italiennes de Biologie, 154(4), 118-124.
https://doi.org/10.12871/00039829201441

Martać L, Sekulić S, Cvijanović M. Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum. in Archives Italiennes de Biologie. 2016;154(4):118-124.
doi:10.12871/00039829201441 .

Martać, Ljiljana, Sekulić, Slobodan, Cvijanović, Milan, "Electrocortical spectral analysis and fractal methods for assessing the effects of unilateral brain injury on rat cerebellum" in Archives Italiennes de Biologie, 154, no. 4 (2016):118-124,
https://doi.org/10.12871/00039829201441 . .

TY  - THES
AU  - Podgorac, Jelena
PY  - 2014
UR  - http://eteze.kg.ac.rs/application/showtheses?thesesId=1324
UR  - https://fedorakg.kg.ac.rs/fedora/get/o:409/bdef:Content/download
UR  - http://nardus.mpn.gov.rs/123456789/3741
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/2441
AB  - Osnovni cilj ove doktorske disertacije je bio da se ispitaju posledice intrauterinog izlaganja različitim dozama valproata na tok fizičkog i psihomotornog razvoja jedinki miša. Ispitivani su efekti valproata na CNS-u u subterapijskim dozama i dozno- zavisni efekat. Testovi primenjeni na potomstvu su u literaturi okarakterisani kao odgovarajući za procenu stanja motornog i senzornog sistema u određenoj fazi postnatalnog razvoja. Određeni testovi, pored opšte motorne sposobnosti, omogućavali su i procenu ponašanja tipa anksioznosti / depresije, hiper- i hipoaktivnosti jedinki.
Metode. U eksperimentima su korišćene ženke i mužjaci zdravih laboratorijskih miševa soja NMRI, odabrane metodom slučajnog izbora iz okota na Vojnomedicinskoj akademiji u Beogradu. Eksperiment je počinjao sparivanjem dve ženke i jednog mužjaka u jednom kavezu. Shodno tretmanu, oformljeno je 5 eksperimentalnih grupa i to jedna kontrolna (n=9 ženki), koja je bila tretirana fiziološkim rastvorom (Natrii Chloridi Infundibule 0,9%, HemofarmhospitalLogica), i 4 grupe koje su tretirane valproatom (Valproic acid sodium salt – 2 propylpentanoic sodium, ≥98, P4543 Sigma Aldrich) u dozi od 50 mg/kg, 100 mg/kg, 200 mg/kg ili 400 mg/kg (n=10-11 ženki po grupi). Natrijumova so valproinske kiseline rastvarana je u fiziološkom rastvoru. Injeciranje je obavljano svakodnevno, od momenta sparivanja, tokom čitavog perioda priploda i gestacije. Nakon rađanja potomstva tretman je prestajao i ženke su sa svojim potomstvom odvajane u zasebne kaveze. Pristup hrani i vodi je bio neograničen.
Procenjivan je odgovor potomstva u sledećim testovima: (1) test refleksa uspravljanja , (2)test kačenja o rep, (3) test izlaganja vrućoj ploči, (4) test uzdignutog krstastog lavirinta, (5) test otvorenog polja
Rezultati. Kontinuirana primena različitih doza valproata (50, 100, 200 i 400 mg/kg) na ženkama miša NMRI soja u periodu priploda ima negativan dozno-zavisni uticaj na fertilitet, a kontinuirana primena u periodu priploda i gestacije na smrtnost ženki (akcenat na visokim dozama). Tretman nema značajnog uticaja na telesnu težinu ženki.
Intrauterino izlaganje valproatu ima negativan uticaj na telesnu težinu jedinki tokom postnatalnog razvoja, uključujući period adolescencije. Tretman je povezan i sa kašnjenjem u otvaranju očiju jedinki u periodu do 15. dana postanatalnog razvoja.
Intrauterino izlaganje različitim dozama valproata značajno utiče na ponašanje jedinki u testu uspravljanja. Shodno starosti jedinki efekat tretmana se ogleda kako u kvalitetu (tipu) odgovora i u vremenu koje je potrebno jedinki da se uspravi.
Tretman valproatom tokom prenatalnog perioda utiče na ishod testa kačenja o rep kada se jedinke testiraju u periodu od 5. do 10. postnatalnog dana (sa akcentom na doze 200 mg/kg i 400 mg/kg). Kod jedinki starih 15 postnatalnih dana posledice tretmana nisu uočene.
Intrauterino izlaganje valproatu značajno utiče na ishod u testu izlaganja vrućoj ploči jedinki starih 25 i 32 postnatalna dana. Efekat se ogleda u povećanju broja jedinki koje neadekvatno odgovaraju na test, kao i u produženoj latenci odgovora na stimulus kod jedinki koje adekvatno odgovore na test.
Izlaganje majki tokom trudnoće valproatu značajno utiče na ponašanje adolescentnog potomstva (PND35) u testu uzdignutog krstastog lavirinta, a posledice su dozno- i polno-specifične. U testu otvorenog polja (PND40), izlaganje majki tokom trudnoće valproatu značajno utiče na ponašanje adolescentnog potomstva oba pola. Shodno primenjenoj dozi, efekat se ogleda u finom narušavanju analiziranih parametara (lokomotorna, stereotipna ili vertikalna aktivnost) u određenom periodu boravka u otvorenom polju.
Zaključak. Primenjeni eksperimentalni model kontirnuirane aplikacije valproata tokom priploda i gestacije na jedinkama miša je u korelaciji sa njegovom terapijskom primenom u tretmanu epilepsija tokom trudnoće u humanoj populaciji. Rezultati dobijeni u našim istraživanjima su jasno ukazali da posledice intrauterinog izlaganja valproatu zavise kako od primenjene doze tako i od pola potomstva. Od posebnog značaja su pokazatelji da subterapijske doze valproata primenjene tokom gestacije značajno utiču na psihomotorni razvoj jedinki. U metodološkom smislu naši eksperimenti su pokazali da za pravilno sagledavanje posledica intrauterinog izlaganja valproatu mora da postoji adekvatan opseg postnatalnih starosti jedinki. Shodno činjenici da je metabolizam valproata kod jedinki miševa ubrzan u odnosu na metabolizam ovog leka u humanoj populaciji, kritički pristup u aproksimaciji podataka dobijenih iz animalnog modela miša na ljudsku populaciju je neophodan.
Cilj ove doktorske disertacije je bio da se ispitaju posledice intrauterinog izlaganja različitim dozama valproata (sa akcentom na subterapijske doze) na psihomotorni razvoj jedinki miša, koje su testirane u različitim fazama postnatalnog razvoja. Baterija testova za ispitivanje ponašanja koja je upotrebljena tokom ove studije uključivala je sledeće testove: test refleksa uspravljanja i test kačenja o rep – tokom prve dve postnatalne nedelje, test izlaganja vrućoj ploči – u periadolescentnoj fazi, test uzdignutog krstastog lavirinta i test otvorenog polja – tokom adolescencije.
Podaci dobijeni u testu refleksa uspravljanja i testu kačenja jedinke o rep su jasno ukazali na kašnjenje u razvoju senzornog i motornog sistema jedinki koje su tokom gestacije bile izložene različitim dozama valproata, koje je uočljivo kroz kvalitativno i kvantitativno drugačiji odgovor jedinki na date testove u periodu ranog postnatalnog razvoja. Velike fizičke anomalije nisu detektovane, ali je jasno pokazan negativan uticaj intrauterinog izlaganja valproatu na telesnu težinu i otvaranje očiju. Podaci dobijeni u testu vruće ploče su dodatno ukazali na kašnjenje u sazrevanju senzornog sistema značajnog za percepciju bolnog stimulusa, sa posebnim akcentom na uticaj malih
5
doza valproata. Testovi primenjeni na jedinkama u periodu adolescencije su ukazali da intrauterino izlaganje valproatu izaziva polno- i dozno-specifične promene u ponašanju, u smislu anksiozno/depresivnih stanja kod jedinki muškog pola usled primene velikih doza valproata i hiperaktivnih stanja kod jedinki ženskog pola usled primene malih doza valproata.
Rezultati dobijeni u ovom istraživanju pružaju mogućnost sagledavanja posledica primene valproata tokom trudnoće na funkcionisanje centralnog nervnog sistema potomstva, sa aspekta ponašanja. U skladu sa literaturom, naši eksperimenti su ukazali da intrauterino izlaganje valproatu izaziva kompleksne promene u ponašanju potomstva, usled morfo-funkcionalnih poremećaja u određenim moždanim regionima. Ipak, ostaje da se precizno utvrde neuralni korelati bihejvioralnih efekata opisanih u našoj studiji koja je za model imala kontinuiranu primenu valproata tokom čitave gestacije, što je eksperimentalno za sada nedovoljno ispitano.
AB  - The aim of this study was to examine the effects of intrauterine exposure to different doses of valproate on the course of physical and psychomotor development of mouse. The effects of valproate in the CNS was evaluated at subtherapeutic doses and dose-dependent effect. 
The tests applied to the offspring in the literature are labeled as suitable for the assessment of motor and sensory system at a certain stage of postnatal development. Certain tests, in addition to general motor skills, allowed the assessment of behavioral state as anxiety / depression, hyper-and hypo-activity of offspring. 
The study was done on adult female NMRI mice. Four experimental and one control group was formed. Females were treated with subcutaneous injection of 50, 100, 200 and 400 mg/kg VPA (Valproic acid sodium salt – 2 propylpentanoic sodium, ≥98, P4543 Sigma Aldrich) or with saline (Natrii Chloridi Infundibule 0,9%, HemofarmhospitalLogica) (control group). All treatments were performed during breeding and whole gestation period. Mice were given ad libitum access to food and water. The offspring was examined in tests: 
(1) Righting test, (2) Tail suspension test, (3) Hot plate test, (4) Elevated plus maze test and (5) Open field test 
Results: Different doses of VPA (50, 100, 200 and 400 mg/kg) continuously applied on female NMRI mice during breeding and whole gestation caused female mortality and lower fertility dose-dependent effect. Treatment had no influence on female body weight. 
In utero exposure to valproate has a negative impact on body weight of individuals during postnatal development, including the adolescence. Treatment is associated with a delay in eye-opening at the 15th postnatal day (PND). 
Prenatal exposition to different doses of VPA significantly influence on offspring behaviour in righting reflex. Regarding the critical developmental postnatal points, treatment influence on type response and latency during righting reflex testing. 
VPA treatment during gestation affect outcome of tail suspension test at the 5th and 10th PND (regarding the doses of 200 and 400mg/kg). There are no concequences in treated groups in tst at 15th PND. 
VPA exposition in utero distinctly influence on outcome during hot plate testing at 25th and 32nd PND. Increased procent of inadequately response and extended latency in adequate response of treated mice was obtained in hot plate test. 
Offspring which mothers were treated with VPA shown different pattern of behaviour (dose- and gender- dependent) during adolescence in elevated plus maze test (PND 35). Mice prenataly exposed to VPA during adolescence (PND40), represent significant differences during locomotor, stereotipic and vertical activity in the open field test. 
Conclusion: Experimental model of continuous application of VPA during breeding and gestation on mice is congruent with therapeutic application in epilepsy treatment during pregnancy in human population. Obtained results in this study indicate that exposure to VPA induce the effect which is dose- and gender-dependent. A subtherapeutic doses applied during gestation significantly influence on the course of psychomotor development. Methodolically, this experiments had shown that the consequences of exposition to valproate in-utero must be examined during adequate postnatal period. Mice has higher rate of VPA metabolism compared with the human rate. Regarding this fact, critical approach must be considered in approximation of the results obtained from animal model of mice to human population.
PB  - Kragujevac: University of Kragujevac, Faculty of Medical Sciences
T2  - University of Kragujevac, Faculty of Medical Sciences
T1  - Uticaj primene valproične kiseline tokom priploda i gestacije na animalnom modelu miša - efekat na psihomotorni razvoj kod potomaka
T1  - Influence of valproic acid application during breeding and gestation in the mouse animal model - effect on psychomotor development in offspring
SP  - 1
EP  - 133
UR  - https://hdl.handle.net/21.15107/rcub_nardus_3741
ER  - 

@phdthesis{
author = "Podgorac, Jelena",
year = "2014",
abstract = "Osnovni cilj ove doktorske disertacije je bio da se ispitaju posledice intrauterinog izlaganja različitim dozama valproata na tok fizičkog i psihomotornog razvoja jedinki miša. Ispitivani su efekti valproata na CNS-u u subterapijskim dozama i dozno- zavisni efekat. Testovi primenjeni na potomstvu su u literaturi okarakterisani kao odgovarajući za procenu stanja motornog i senzornog sistema u određenoj fazi postnatalnog razvoja. Određeni testovi, pored opšte motorne sposobnosti, omogućavali su i procenu ponašanja tipa anksioznosti / depresije, hiper- i hipoaktivnosti jedinki.
Metode. U eksperimentima su korišćene ženke i mužjaci zdravih laboratorijskih miševa soja NMRI, odabrane metodom slučajnog izbora iz okota na Vojnomedicinskoj akademiji u Beogradu. Eksperiment je počinjao sparivanjem dve ženke i jednog mužjaka u jednom kavezu. Shodno tretmanu, oformljeno je 5 eksperimentalnih grupa i to jedna kontrolna (n=9 ženki), koja je bila tretirana fiziološkim rastvorom (Natrii Chloridi Infundibule 0,9%, HemofarmhospitalLogica), i 4 grupe koje su tretirane valproatom (Valproic acid sodium salt – 2 propylpentanoic sodium, ≥98, P4543 Sigma Aldrich) u dozi od 50 mg/kg, 100 mg/kg, 200 mg/kg ili 400 mg/kg (n=10-11 ženki po grupi). Natrijumova so valproinske kiseline rastvarana je u fiziološkom rastvoru. Injeciranje je obavljano svakodnevno, od momenta sparivanja, tokom čitavog perioda priploda i gestacije. Nakon rađanja potomstva tretman je prestajao i ženke su sa svojim potomstvom odvajane u zasebne kaveze. Pristup hrani i vodi je bio neograničen.
Procenjivan je odgovor potomstva u sledećim testovima: (1) test refleksa uspravljanja , (2)test kačenja o rep, (3) test izlaganja vrućoj ploči, (4) test uzdignutog krstastog lavirinta, (5) test otvorenog polja
Rezultati. Kontinuirana primena različitih doza valproata (50, 100, 200 i 400 mg/kg) na ženkama miša NMRI soja u periodu priploda ima negativan dozno-zavisni uticaj na fertilitet, a kontinuirana primena u periodu priploda i gestacije na smrtnost ženki (akcenat na visokim dozama). Tretman nema značajnog uticaja na telesnu težinu ženki.
Intrauterino izlaganje valproatu ima negativan uticaj na telesnu težinu jedinki tokom postnatalnog razvoja, uključujući period adolescencije. Tretman je povezan i sa kašnjenjem u otvaranju očiju jedinki u periodu do 15. dana postanatalnog razvoja.
Intrauterino izlaganje različitim dozama valproata značajno utiče na ponašanje jedinki u testu uspravljanja. Shodno starosti jedinki efekat tretmana se ogleda kako u kvalitetu (tipu) odgovora i u vremenu koje je potrebno jedinki da se uspravi.
Tretman valproatom tokom prenatalnog perioda utiče na ishod testa kačenja o rep kada se jedinke testiraju u periodu od 5. do 10. postnatalnog dana (sa akcentom na doze 200 mg/kg i 400 mg/kg). Kod jedinki starih 15 postnatalnih dana posledice tretmana nisu uočene.
Intrauterino izlaganje valproatu značajno utiče na ishod u testu izlaganja vrućoj ploči jedinki starih 25 i 32 postnatalna dana. Efekat se ogleda u povećanju broja jedinki koje neadekvatno odgovaraju na test, kao i u produženoj latenci odgovora na stimulus kod jedinki koje adekvatno odgovore na test.
Izlaganje majki tokom trudnoće valproatu značajno utiče na ponašanje adolescentnog potomstva (PND35) u testu uzdignutog krstastog lavirinta, a posledice su dozno- i polno-specifične. U testu otvorenog polja (PND40), izlaganje majki tokom trudnoće valproatu značajno utiče na ponašanje adolescentnog potomstva oba pola. Shodno primenjenoj dozi, efekat se ogleda u finom narušavanju analiziranih parametara (lokomotorna, stereotipna ili vertikalna aktivnost) u određenom periodu boravka u otvorenom polju.
Zaključak. Primenjeni eksperimentalni model kontirnuirane aplikacije valproata tokom priploda i gestacije na jedinkama miša je u korelaciji sa njegovom terapijskom primenom u tretmanu epilepsija tokom trudnoće u humanoj populaciji. Rezultati dobijeni u našim istraživanjima su jasno ukazali da posledice intrauterinog izlaganja valproatu zavise kako od primenjene doze tako i od pola potomstva. Od posebnog značaja su pokazatelji da subterapijske doze valproata primenjene tokom gestacije značajno utiču na psihomotorni razvoj jedinki. U metodološkom smislu naši eksperimenti su pokazali da za pravilno sagledavanje posledica intrauterinog izlaganja valproatu mora da postoji adekvatan opseg postnatalnih starosti jedinki. Shodno činjenici da je metabolizam valproata kod jedinki miševa ubrzan u odnosu na metabolizam ovog leka u humanoj populaciji, kritički pristup u aproksimaciji podataka dobijenih iz animalnog modela miša na ljudsku populaciju je neophodan.
Cilj ove doktorske disertacije je bio da se ispitaju posledice intrauterinog izlaganja različitim dozama valproata (sa akcentom na subterapijske doze) na psihomotorni razvoj jedinki miša, koje su testirane u različitim fazama postnatalnog razvoja. Baterija testova za ispitivanje ponašanja koja je upotrebljena tokom ove studije uključivala je sledeće testove: test refleksa uspravljanja i test kačenja o rep – tokom prve dve postnatalne nedelje, test izlaganja vrućoj ploči – u periadolescentnoj fazi, test uzdignutog krstastog lavirinta i test otvorenog polja – tokom adolescencije.
Podaci dobijeni u testu refleksa uspravljanja i testu kačenja jedinke o rep su jasno ukazali na kašnjenje u razvoju senzornog i motornog sistema jedinki koje su tokom gestacije bile izložene različitim dozama valproata, koje je uočljivo kroz kvalitativno i kvantitativno drugačiji odgovor jedinki na date testove u periodu ranog postnatalnog razvoja. Velike fizičke anomalije nisu detektovane, ali je jasno pokazan negativan uticaj intrauterinog izlaganja valproatu na telesnu težinu i otvaranje očiju. Podaci dobijeni u testu vruće ploče su dodatno ukazali na kašnjenje u sazrevanju senzornog sistema značajnog za percepciju bolnog stimulusa, sa posebnim akcentom na uticaj malih
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doza valproata. Testovi primenjeni na jedinkama u periodu adolescencije su ukazali da intrauterino izlaganje valproatu izaziva polno- i dozno-specifične promene u ponašanju, u smislu anksiozno/depresivnih stanja kod jedinki muškog pola usled primene velikih doza valproata i hiperaktivnih stanja kod jedinki ženskog pola usled primene malih doza valproata.
Rezultati dobijeni u ovom istraživanju pružaju mogućnost sagledavanja posledica primene valproata tokom trudnoće na funkcionisanje centralnog nervnog sistema potomstva, sa aspekta ponašanja. U skladu sa literaturom, naši eksperimenti su ukazali da intrauterino izlaganje valproatu izaziva kompleksne promene u ponašanju potomstva, usled morfo-funkcionalnih poremećaja u određenim moždanim regionima. Ipak, ostaje da se precizno utvrde neuralni korelati bihejvioralnih efekata opisanih u našoj studiji koja je za model imala kontinuiranu primenu valproata tokom čitave gestacije, što je eksperimentalno za sada nedovoljno ispitano., The aim of this study was to examine the effects of intrauterine exposure to different doses of valproate on the course of physical and psychomotor development of mouse. The effects of valproate in the CNS was evaluated at subtherapeutic doses and dose-dependent effect. 
The tests applied to the offspring in the literature are labeled as suitable for the assessment of motor and sensory system at a certain stage of postnatal development. Certain tests, in addition to general motor skills, allowed the assessment of behavioral state as anxiety / depression, hyper-and hypo-activity of offspring. 
The study was done on adult female NMRI mice. Four experimental and one control group was formed. Females were treated with subcutaneous injection of 50, 100, 200 and 400 mg/kg VPA (Valproic acid sodium salt – 2 propylpentanoic sodium, ≥98, P4543 Sigma Aldrich) or with saline (Natrii Chloridi Infundibule 0,9%, HemofarmhospitalLogica) (control group). All treatments were performed during breeding and whole gestation period. Mice were given ad libitum access to food and water. The offspring was examined in tests: 
(1) Righting test, (2) Tail suspension test, (3) Hot plate test, (4) Elevated plus maze test and (5) Open field test 
Results: Different doses of VPA (50, 100, 200 and 400 mg/kg) continuously applied on female NMRI mice during breeding and whole gestation caused female mortality and lower fertility dose-dependent effect. Treatment had no influence on female body weight. 
In utero exposure to valproate has a negative impact on body weight of individuals during postnatal development, including the adolescence. Treatment is associated with a delay in eye-opening at the 15th postnatal day (PND). 
Prenatal exposition to different doses of VPA significantly influence on offspring behaviour in righting reflex. Regarding the critical developmental postnatal points, treatment influence on type response and latency during righting reflex testing. 
VPA treatment during gestation affect outcome of tail suspension test at the 5th and 10th PND (regarding the doses of 200 and 400mg/kg). There are no concequences in treated groups in tst at 15th PND. 
VPA exposition in utero distinctly influence on outcome during hot plate testing at 25th and 32nd PND. Increased procent of inadequately response and extended latency in adequate response of treated mice was obtained in hot plate test. 
Offspring which mothers were treated with VPA shown different pattern of behaviour (dose- and gender- dependent) during adolescence in elevated plus maze test (PND 35). Mice prenataly exposed to VPA during adolescence (PND40), represent significant differences during locomotor, stereotipic and vertical activity in the open field test. 
Conclusion: Experimental model of continuous application of VPA during breeding and gestation on mice is congruent with therapeutic application in epilepsy treatment during pregnancy in human population. Obtained results in this study indicate that exposure to VPA induce the effect which is dose- and gender-dependent. A subtherapeutic doses applied during gestation significantly influence on the course of psychomotor development. Methodolically, this experiments had shown that the consequences of exposition to valproate in-utero must be examined during adequate postnatal period. Mice has higher rate of VPA metabolism compared with the human rate. Regarding this fact, critical approach must be considered in approximation of the results obtained from animal model of mice to human population.",
publisher = "Kragujevac: University of Kragujevac, Faculty of Medical Sciences",
journal = "University of Kragujevac, Faculty of Medical Sciences",
title = "Uticaj primene valproične kiseline tokom priploda i gestacije na animalnom modelu miša - efekat na psihomotorni razvoj kod potomaka, Influence of valproic acid application during breeding and gestation in the mouse animal model - effect on psychomotor development in offspring",
pages = "1-133",
url = "https://hdl.handle.net/21.15107/rcub_nardus_3741"
}

Podgorac, J.. (2014). Uticaj primene valproične kiseline tokom priploda i gestacije na animalnom modelu miša - efekat na psihomotorni razvoj kod potomaka. in University of Kragujevac, Faculty of Medical Sciences
Kragujevac: University of Kragujevac, Faculty of Medical Sciences., 1-133.
https://hdl.handle.net/21.15107/rcub_nardus_3741

Podgorac J. Uticaj primene valproične kiseline tokom priploda i gestacije na animalnom modelu miša - efekat na psihomotorni razvoj kod potomaka. in University of Kragujevac, Faculty of Medical Sciences. 2014;:1-133.
https://hdl.handle.net/21.15107/rcub_nardus_3741 .

Podgorac, Jelena, "Uticaj primene valproične kiseline tokom priploda i gestacije na animalnom modelu miša - efekat na psihomotorni razvoj kod potomaka" in University of Kragujevac, Faculty of Medical Sciences (2014):1-133,
https://hdl.handle.net/21.15107/rcub_nardus_3741 .

TY  - JOUR
AU  - Sekulić, Slobodan
AU  - Ilinčić, Marko
AU  - Radeka, Gordana
AU  - Novaković- Mikić, Aleksandra
AU  - Simić, Svetlana
AU  - Podgorac, Jelena
AU  - Keković, Goran
PY  - 2013
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6809
AB  - Aim
To investigate the association of cornual-fundal location of the placenta and breech presentation at term delivery.
Methods
This study was conducted at the Department of Obstetrics and Gynecology, Novi Sad, in 2011. The inclusion criteria were delivery at ≥37 weeks of gestation, singleton gestation, and cornual-fundal location of the placenta determined by ultrasonography at ≥37 weeks of gestation when 3/4 or more of the placenta was in the cornual-fundal region.
Results
Out of 2750 ultrasound examinations performed, 143 showed cornual-fundal location of the placenta (frequency 5.2%). Eighty six cases had cephalic presentation (60.14%) and 57 (39.86%) had breech presentation. Of the remaining cases with non- cornual-fundal location, 2585 had cephalic presentation and 22 (0.84%) had breech presentation. The difference in the frequency of breech presentation between the cornual-fundal and non-cornual-fundal groups was significant (χ2 = 77.78, P < 0.001).
Conclusion
Cornual-fundal location of the placenta may be an important clue in resolving the etiology of a number of cases of breech presentation at term delivery.
PB  - Zagreb: Medicinska naklada
T2  - Croatian Medical Journal
T1  - Breech Presentation and the cornual-fundal location on the placenta
IS  - 2
VL  - 54
DO  - 10.3325/cmj.2013.54.198
SP  - 198
EP  - 202
ER  - 

@article{
author = "Sekulić, Slobodan and Ilinčić, Marko and Radeka, Gordana and Novaković- Mikić, Aleksandra and Simić, Svetlana and Podgorac, Jelena and Keković, Goran",
year = "2013",
abstract = "Aim
To investigate the association of cornual-fundal location of the placenta and breech presentation at term delivery.
Methods
This study was conducted at the Department of Obstetrics and Gynecology, Novi Sad, in 2011. The inclusion criteria were delivery at ≥37 weeks of gestation, singleton gestation, and cornual-fundal location of the placenta determined by ultrasonography at ≥37 weeks of gestation when 3/4 or more of the placenta was in the cornual-fundal region.
Results
Out of 2750 ultrasound examinations performed, 143 showed cornual-fundal location of the placenta (frequency 5.2%). Eighty six cases had cephalic presentation (60.14%) and 57 (39.86%) had breech presentation. Of the remaining cases with non- cornual-fundal location, 2585 had cephalic presentation and 22 (0.84%) had breech presentation. The difference in the frequency of breech presentation between the cornual-fundal and non-cornual-fundal groups was significant (χ2 = 77.78, P < 0.001).
Conclusion
Cornual-fundal location of the placenta may be an important clue in resolving the etiology of a number of cases of breech presentation at term delivery.",
publisher = "Zagreb: Medicinska naklada",
journal = "Croatian Medical Journal",
title = "Breech Presentation and the cornual-fundal location on the placenta",
number = "2",
volume = "54",
doi = "10.3325/cmj.2013.54.198",
pages = "198-202"
}

Sekulić, S., Ilinčić, M., Radeka, G., Novaković- Mikić, A., Simić, S., Podgorac, J.,& Keković, G.. (2013). Breech Presentation and the cornual-fundal location on the placenta. in Croatian Medical Journal
Zagreb: Medicinska naklada., 54(2), 198-202.
https://doi.org/10.3325/cmj.2013.54.198

Sekulić S, Ilinčić M, Radeka G, Novaković- Mikić A, Simić S, Podgorac J, Keković G. Breech Presentation and the cornual-fundal location on the placenta. in Croatian Medical Journal. 2013;54(2):198-202.
doi:10.3325/cmj.2013.54.198 .

Sekulić, Slobodan, Ilinčić, Marko, Radeka, Gordana, Novaković- Mikić, Aleksandra, Simić, Svetlana, Podgorac, Jelena, Keković, Goran, "Breech Presentation and the cornual-fundal location on the placenta" in Croatian Medical Journal, 54, no. 2 (2013):198-202,
https://doi.org/10.3325/cmj.2013.54.198 . .