TY  - JOUR
AU  - Gozzi, Marta
AU  - Murganic, Blagoje
AU  - Drača, Dijana
AU  - Popp, John
AU  - Coburger, Peter
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Hey-Hawkins, Evamarie
PY  - 2019
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201900349
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3534
AB  - The role of autophagy in cancer is often complex, ranging from tumor-promoting to -suppressing effects. In this study, two novel hybrid molecules were designed, containing a ruthenacarborane fragment conjugated with a known modulator of autophagy, namely a quinoline derivative. The complex closo-[3-(η6 -p-cymene)-1-(quinolin-8-yl-acetate)-3,1,2-RuC2 B9 H10 ] (4) showed a dual mode of action against the LN229 (human glioblastoma) cell line, where it inhibited tumor-promoting autophagy, and strongly inhibited cell proliferation, de facto blocking cellular division. These results, together with the tendency to spontaneously form nanoparticles in aqueous solution, make complex 4 a very promising drug candidate for further studies in vivo, for the treatment of autophagy-prone glioblastomas.
T2  - ChemMedChem
T1  - Quinoline-Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action.
DO  - 10.1002/cmdc.201900349
ER  - 

@article{
author = "Gozzi, Marta and Murganic, Blagoje and Drača, Dijana and Popp, John and Coburger, Peter and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Hey-Hawkins, Evamarie",
year = "2019",
abstract = "The role of autophagy in cancer is often complex, ranging from tumor-promoting to -suppressing effects. In this study, two novel hybrid molecules were designed, containing a ruthenacarborane fragment conjugated with a known modulator of autophagy, namely a quinoline derivative. The complex closo-[3-(η6 -p-cymene)-1-(quinolin-8-yl-acetate)-3,1,2-RuC2 B9 H10 ] (4) showed a dual mode of action against the LN229 (human glioblastoma) cell line, where it inhibited tumor-promoting autophagy, and strongly inhibited cell proliferation, de facto blocking cellular division. These results, together with the tendency to spontaneously form nanoparticles in aqueous solution, make complex 4 a very promising drug candidate for further studies in vivo, for the treatment of autophagy-prone glioblastomas.",
journal = "ChemMedChem",
title = "Quinoline-Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action.",
doi = "10.1002/cmdc.201900349"
}

Gozzi, M., Murganic, B., Drača, D., Popp, J., Coburger, P., Maksimović-Ivanić, D., Mijatović, S.,& Hey-Hawkins, E.. (2019). Quinoline-Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action.. in ChemMedChem.
https://doi.org/10.1002/cmdc.201900349

Gozzi M, Murganic B, Drača D, Popp J, Coburger P, Maksimović-Ivanić D, Mijatović S, Hey-Hawkins E. Quinoline-Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action.. in ChemMedChem. 2019;.
doi:10.1002/cmdc.201900349 .

Gozzi, Marta, Murganic, Blagoje, Drača, Dijana, Popp, John, Coburger, Peter, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Hey-Hawkins, Evamarie, "Quinoline-Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action." in ChemMedChem (2019),
https://doi.org/10.1002/cmdc.201900349 . .