TY  - CONF
AU  - Jelača, Sanja
AU  - Mijatović, Sanja
AU  - Dajić-Stevanović, Zora
AU  - Arsenijević, Nebojša
AU  - Maksimović-Ivanić, Danijela
PY  - 2022
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5286
AB  - Eryngium amethystinum is herb from Apiaceae family. It has been used as a food or in traditional medicine for the treatment of various diseases1. In the present work, we have evaluated its cytotoxic effect on a panel of human cancer cells (human breast carcinoma MCF7, human malignant melanoma A375, human colon carcinoma HCT116 and human lung cancer A549). Treatment with Eryngium amethystinum ethanol extract decreased viability of all cancer cell lines in a dose-dependent manner after 72 h. For further investigation of potential mechanism of action A549 cell line was selected. The observed viability decrease was followed by loss of dividing potential after the treatment. Aditionaly, 90% of A549 cells were subjected to programmed cell death ̶ apoptosis which was not followed with caspase activation. In paralel with this, typical apoptotic morphology of treated cells was observed by fluorescent microscopy. Apart from this decreased cell viability was due to triggered autophagic cell death. Taken together, the shown effect of Eryngium amethystinum makes this plant worthwhile for further evaluation in the field of oncology.
PB  - Belgrade: Faculty of Chemistry
C3  - Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
T1  - Antitumor properties of Eryngium amethystinum extract
SP  - 75
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_5286
ER  - 

@conference{
author = "Jelača, Sanja and Mijatović, Sanja and Dajić-Stevanović, Zora and Arsenijević, Nebojša and Maksimović-Ivanić, Danijela",
year = "2022",
abstract = "Eryngium amethystinum is herb from Apiaceae family. It has been used as a food or in traditional medicine for the treatment of various diseases1. In the present work, we have evaluated its cytotoxic effect on a panel of human cancer cells (human breast carcinoma MCF7, human malignant melanoma A375, human colon carcinoma HCT116 and human lung cancer A549). Treatment with Eryngium amethystinum ethanol extract decreased viability of all cancer cell lines in a dose-dependent manner after 72 h. For further investigation of potential mechanism of action A549 cell line was selected. The observed viability decrease was followed by loss of dividing potential after the treatment. Aditionaly, 90% of A549 cells were subjected to programmed cell death ̶ apoptosis which was not followed with caspase activation. In paralel with this, typical apoptotic morphology of treated cells was observed by fluorescent microscopy. Apart from this decreased cell viability was due to triggered autophagic cell death. Taken together, the shown effect of Eryngium amethystinum makes this plant worthwhile for further evaluation in the field of oncology.",
publisher = "Belgrade: Faculty of Chemistry",
journal = "Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia",
title = "Antitumor properties of Eryngium amethystinum extract",
pages = "75",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5286"
}

Jelača, S., Mijatović, S., Dajić-Stevanović, Z., Arsenijević, N.,& Maksimović-Ivanić, D.. (2022). Antitumor properties of Eryngium amethystinum extract. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia
Belgrade: Faculty of Chemistry., 75.
https://hdl.handle.net/21.15107/rcub_ibiss_5286

Jelača S, Mijatović S, Dajić-Stevanović Z, Arsenijević N, Maksimović-Ivanić D. Antitumor properties of Eryngium amethystinum extract. in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia. 2022;:75.
https://hdl.handle.net/21.15107/rcub_ibiss_5286 .

Jelača, Sanja, Mijatović, Sanja, Dajić-Stevanović, Zora, Arsenijević, Nebojša, Maksimović-Ivanić, Danijela, "Antitumor properties of Eryngium amethystinum extract" in Proceedings: Serbian Biochemical Society, Eleventh Conference, Scientific meeting of an international character: "Amazing Biochemistry"; 2022 Sep 22-23; Novi Sad, Serbia (2022):75,
https://hdl.handle.net/21.15107/rcub_ibiss_5286 .