TY  - JOUR
AU  - Schwarze, Benedikt
AU  - Jelača, Sanja
AU  - Welcke, Linda
AU  - Maksimović-Ivanić, Danijela
AU  - Mijatović, Sanja
AU  - Hey-Hawkins, Evamarie
PY  - 2019
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201900554
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3531
AB  - Investigations on the antitumor activity of metallacarboranes are sparse in the literature and limited to a handful of ruthena- and molybdacarboranes. In this study, the molybdacarborane fragment [3-(CO)2 -closo-3,1,2-MoC2 B9 H11 ] was combined with a vector molecule, inspired by the well-known drug tamoxifen or 4,4'-dihydroxytamoxifen (TAM-diOH). The molybdacarborane derivative [3,3-{4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2'-bipyridine-κ2 N,N'}-3-(CO)2 -closo-3,1,2-MoC2 B9 H11 ] (10), as well as the ligand itself 4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2'-bipyridine (6) showed cytotoxic activities in the low micromolar range against breast adenocarcinoma (MDA-MB-231, MDA-MB-361 and MCF-7), human glioblastoma (LN-229) and human glioma (U-251) cell lines. In addition, compounds 6 and 10 were found to induce senescence and cytodestructive autophagy, lower ROS/RNS levels, but only the molybdacarborane 10 induced a strong increase of nitric oxide (NO) concentration in the MCF-7 cells.
T2  - ChemMedChem
T1  - 2,2'-Bipyridine-Modified Tamoxifen: A Versatile Vector for Molybdacarboranes.
IS  - 24
VL  - 14
DO  - 10.1002/cmdc.201900554
SP  - 2075
EP  - 2083
ER  - 

@article{
author = "Schwarze, Benedikt and Jelača, Sanja and Welcke, Linda and Maksimović-Ivanić, Danijela and Mijatović, Sanja and Hey-Hawkins, Evamarie",
year = "2019",
abstract = "Investigations on the antitumor activity of metallacarboranes are sparse in the literature and limited to a handful of ruthena- and molybdacarboranes. In this study, the molybdacarborane fragment [3-(CO)2 -closo-3,1,2-MoC2 B9 H11 ] was combined with a vector molecule, inspired by the well-known drug tamoxifen or 4,4'-dihydroxytamoxifen (TAM-diOH). The molybdacarborane derivative [3,3-{4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2'-bipyridine-κ2 N,N'}-3-(CO)2 -closo-3,1,2-MoC2 B9 H11 ] (10), as well as the ligand itself 4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2'-bipyridine (6) showed cytotoxic activities in the low micromolar range against breast adenocarcinoma (MDA-MB-231, MDA-MB-361 and MCF-7), human glioblastoma (LN-229) and human glioma (U-251) cell lines. In addition, compounds 6 and 10 were found to induce senescence and cytodestructive autophagy, lower ROS/RNS levels, but only the molybdacarborane 10 induced a strong increase of nitric oxide (NO) concentration in the MCF-7 cells.",
journal = "ChemMedChem",
title = "2,2'-Bipyridine-Modified Tamoxifen: A Versatile Vector for Molybdacarboranes.",
number = "24",
volume = "14",
doi = "10.1002/cmdc.201900554",
pages = "2075-2083"
}

Schwarze, B., Jelača, S., Welcke, L., Maksimović-Ivanić, D., Mijatović, S.,& Hey-Hawkins, E.. (2019). 2,2'-Bipyridine-Modified Tamoxifen: A Versatile Vector for Molybdacarboranes.. in ChemMedChem, 14(24), 2075-2083.
https://doi.org/10.1002/cmdc.201900554

Schwarze B, Jelača S, Welcke L, Maksimović-Ivanić D, Mijatović S, Hey-Hawkins E. 2,2'-Bipyridine-Modified Tamoxifen: A Versatile Vector for Molybdacarboranes.. in ChemMedChem. 2019;14(24):2075-2083.
doi:10.1002/cmdc.201900554 .

Schwarze, Benedikt, Jelača, Sanja, Welcke, Linda, Maksimović-Ivanić, Danijela, Mijatović, Sanja, Hey-Hawkins, Evamarie, "2,2'-Bipyridine-Modified Tamoxifen: A Versatile Vector for Molybdacarboranes." in ChemMedChem, 14, no. 24 (2019):2075-2083,
https://doi.org/10.1002/cmdc.201900554 . .