TY  - JOUR
AU  - Čakmak, Dragan
AU  - Perović, Veljko
AU  - Kresović, Mirjana
AU  - Pavlović, Dragana
AU  - Matić, Marija
AU  - Mitrović, Miroslava
AU  - Pavlović, Pavle
PY  - 2020
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3598
AB  - The focus of this research on children’s playgrounds with artificial surfaces aimed to establish levels of potentially toxic elements (PTEs) in dust, their origin, and impact on children at 15 playgrounds: 9 on school grounds and 6 on day nurseries in Belgrade (Serbia). Soil samples were taken from the immediate vicinity of the playgrounds to establish the origin of PTEs in the dust samples. Soil analyses revealed the lithogenic origin of Co, Cr, Ni, Fe, Mn, As, Cd, Cu, Pb, and Zn and the anthropogenic origin of As, Cd, Cu, Pb, and Zn. However, in the dust samples, the origin of the elements was different with As, Co, Fe, and Mn originating from the surrounding soil; Cr and Ni levels affected by both atmospheric deposition and the surrounding soil; Cd, Pb, and Zn concentrations impacted by atmospheric deposition; and Cu levels affected by factors of a local character. No noncancer risk was found for any of the individual elements investigated, nor for any of the playgrounds being studied, while a minimal cancer risk was found from As with values greater than 1E−6 at almost all the sites. Based on the results obtained for the spatial distribution of individual PTE levels, it was determined that the surrounding soil and atmospheric deposition have an almost equal impact on noncancer risk values.
T2  - Archives of Environmental Contamination and Toxicology
T1  - Sources and a Health Risk Assessment of Potentially Toxic Elements in Dust at Children’s Playgrounds with Artificial Surfaces: A Case Study in Belgrade
IS  - 2
VL  - 78
DO  - 10.1007/s00244-019-00702-0
SP  - 190
EP  - 205
ER  - 

@article{
author = "Čakmak, Dragan and Perović, Veljko and Kresović, Mirjana and Pavlović, Dragana and Matić, Marija and Mitrović, Miroslava and Pavlović, Pavle",
year = "2020",
abstract = "The focus of this research on children’s playgrounds with artificial surfaces aimed to establish levels of potentially toxic elements (PTEs) in dust, their origin, and impact on children at 15 playgrounds: 9 on school grounds and 6 on day nurseries in Belgrade (Serbia). Soil samples were taken from the immediate vicinity of the playgrounds to establish the origin of PTEs in the dust samples. Soil analyses revealed the lithogenic origin of Co, Cr, Ni, Fe, Mn, As, Cd, Cu, Pb, and Zn and the anthropogenic origin of As, Cd, Cu, Pb, and Zn. However, in the dust samples, the origin of the elements was different with As, Co, Fe, and Mn originating from the surrounding soil; Cr and Ni levels affected by both atmospheric deposition and the surrounding soil; Cd, Pb, and Zn concentrations impacted by atmospheric deposition; and Cu levels affected by factors of a local character. No noncancer risk was found for any of the individual elements investigated, nor for any of the playgrounds being studied, while a minimal cancer risk was found from As with values greater than 1E−6 at almost all the sites. Based on the results obtained for the spatial distribution of individual PTE levels, it was determined that the surrounding soil and atmospheric deposition have an almost equal impact on noncancer risk values.",
journal = "Archives of Environmental Contamination and Toxicology",
title = "Sources and a Health Risk Assessment of Potentially Toxic Elements in Dust at Children’s Playgrounds with Artificial Surfaces: A Case Study in Belgrade",
number = "2",
volume = "78",
doi = "10.1007/s00244-019-00702-0",
pages = "190-205"
}

Čakmak, D., Perović, V., Kresović, M., Pavlović, D., Matić, M., Mitrović, M.,& Pavlović, P.. (2020). Sources and a Health Risk Assessment of Potentially Toxic Elements in Dust at Children’s Playgrounds with Artificial Surfaces: A Case Study in Belgrade. in Archives of Environmental Contamination and Toxicology, 78(2), 190-205.
https://doi.org/10.1007/s00244-019-00702-0

Čakmak D, Perović V, Kresović M, Pavlović D, Matić M, Mitrović M, Pavlović P. Sources and a Health Risk Assessment of Potentially Toxic Elements in Dust at Children’s Playgrounds with Artificial Surfaces: A Case Study in Belgrade. in Archives of Environmental Contamination and Toxicology. 2020;78(2):190-205.
doi:10.1007/s00244-019-00702-0 .

Čakmak, Dragan, Perović, Veljko, Kresović, Mirjana, Pavlović, Dragana, Matić, Marija, Mitrović, Miroslava, Pavlović, Pavle, "Sources and a Health Risk Assessment of Potentially Toxic Elements in Dust at Children’s Playgrounds with Artificial Surfaces: A Case Study in Belgrade" in Archives of Environmental Contamination and Toxicology, 78, no. 2 (2020):190-205,
https://doi.org/10.1007/s00244-019-00702-0 . .

TY  - JOUR
AU  - Stikić, Radmila I.
AU  - Milinčić, Danijel D.
AU  - Kostić, Aleksandar Ž.
AU  - Jovanović, Zorica B.
AU  - Gašić, Uroš
AU  - Tešić, Živoslav Lj.
AU  - Djordjević, Nataša Z.
AU  - Savić, Sladjana K.
AU  - Czekus, Borisz G.
AU  - Pešić, Mirjana
PY  - 2020
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/cche.10278
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3639
AB  - Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health‐promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. 13 phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration, and time‐dependent effects were more expressed in Puno extracts. The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT‐116, as well as the presence of 7 new phenolic and flavonoid compounds.
T2  - Cereal Chemistry
T1  - Polyphenolic profiles, antioxidant and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars
IS  - 3
VL  - 97
DO  - 10.1002/cche.10278
SP  - cche.10278
SP  - 626
EP  - 633
ER  - 

@article{
author = "Stikić, Radmila I. and Milinčić, Danijel D. and Kostić, Aleksandar Ž. and Jovanović, Zorica B. and Gašić, Uroš and Tešić, Živoslav Lj. and Djordjević, Nataša Z. and Savić, Sladjana K. and Czekus, Borisz G. and Pešić, Mirjana",
year = "2020",
abstract = "Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health‐promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. 13 phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration, and time‐dependent effects were more expressed in Puno extracts. The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT‐116, as well as the presence of 7 new phenolic and flavonoid compounds.",
journal = "Cereal Chemistry",
title = "Polyphenolic profiles, antioxidant and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars",
number = "3",
volume = "97",
doi = "10.1002/cche.10278",
pages = "cche.10278-626-633"
}

Stikić, R. I., Milinčić, D. D., Kostić, A. Ž., Jovanović, Z. B., Gašić, U., Tešić, Ž. Lj., Djordjević, N. Z., Savić, S. K., Czekus, B. G.,& Pešić, M.. (2020). Polyphenolic profiles, antioxidant and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry, 97(3), cche.10278-633.
https://doi.org/10.1002/cche.10278

Stikić RI, Milinčić DD, Kostić AŽ, Jovanović ZB, Gašić U, Tešić ŽL, Djordjević NZ, Savić SK, Czekus BG, Pešić M. Polyphenolic profiles, antioxidant and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry. 2020;97(3):cche.10278-633.
doi:10.1002/cche.10278 .

Stikić, Radmila I., Milinčić, Danijel D., Kostić, Aleksandar Ž., Jovanović, Zorica B., Gašić, Uroš, Tešić, Živoslav Lj., Djordjević, Nataša Z., Savić, Sladjana K., Czekus, Borisz G., Pešić, Mirjana, "Polyphenolic profiles, antioxidant and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars" in Cereal Chemistry, 97, no. 3 (2020):cche.10278-633,
https://doi.org/10.1002/cche.10278 . .

TY  - JOUR
AU  - Petković Cvetković, Jelena
AU  - Božić, Bojan Đ.
AU  - Banjac, Nebojša R.
AU  - Petrović, Jovana
AU  - Soković, Marina
AU  - Vitnik, Vesna D.
AU  - Vitnik, Željko J.
AU  - Ušćumlić, Gordana S.
AU  - Valentić, Nataša V.
PY  - 2019
UR  - https://www.sciencedirect.com/science/article/pii/S0022286018315163?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3239
AB  - The macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in inflammation, regulation of energy metabolism and glucocorticoid action. Chronic low-grade inflammation may be caused by fructose intake, contributing to visceral adipose tissue (VAT) dysfunction. Since MIF is a known antagonist of glucocorticoid signaling, and deregulated glucocorticoid signaling can contribute to lipid metabolism disturbances, we hypothesized that altered MIF signaling might underlie fructose-induced adiposity through glucocorticoid action. We analyzed physiological and biochemical parameters, adipose tissue histology, insulin sensitivity and lipid metabolism in wild type and MIF-/- C57Bl/6J mice consuming 20% fructose solution for 9 weeks. Glucocorticoid prereceptor metabolism and glucocorticoid receptor (GR) protein level were examined in VAT, together with the expression of glucocorticoid-target genes involved in lipid metabolism. The expression of adipogenic and lipogenic transcriptional regulators peroxisome proliferator activated receptor gamma (PPARG) and sterol regulatory element-binding protein 1c (SREBP1c) was also assessed. Results showed disturbed insulin sensitivity in all MIF-/- mice, regardless of the diet. Mice on fructose diet had increased energy intake, but increased visceral adiposity and enlarged adipocytes were observed only in fructose-fed MIF-/- mice. Increased VAT corticosterone level and 11 beta-hydroxysteroid dehydrogenase type 1, hexose-6-phosphate dehydrogenase and GR protein levels were observed in the same animals, together with induced expression of examined lipogenic genes and accumulation of PPARG and SREBP1c. In conclusion, the results showed that dietary fructose was associated with increased visceral adiposity through activation of GR-regulated lipogenic genes, but only in the absence of MIF, which set the state of hyperinsulinemia and insulin resistance.
T2  - Journal of Molecular Structure
T1  - Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives
VL  - 1181
DO  - 10.1016/j.molstruc.2018.12.083
SP  - 148
EP  - 156
ER  - 

@article{
author = "Petković Cvetković, Jelena and Božić, Bojan Đ. and Banjac, Nebojša R. and Petrović, Jovana and Soković, Marina and Vitnik, Vesna D. and Vitnik, Željko J. and Ušćumlić, Gordana S. and Valentić, Nataša V.",
year = "2019",
abstract = "The macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in inflammation, regulation of energy metabolism and glucocorticoid action. Chronic low-grade inflammation may be caused by fructose intake, contributing to visceral adipose tissue (VAT) dysfunction. Since MIF is a known antagonist of glucocorticoid signaling, and deregulated glucocorticoid signaling can contribute to lipid metabolism disturbances, we hypothesized that altered MIF signaling might underlie fructose-induced adiposity through glucocorticoid action. We analyzed physiological and biochemical parameters, adipose tissue histology, insulin sensitivity and lipid metabolism in wild type and MIF-/- C57Bl/6J mice consuming 20% fructose solution for 9 weeks. Glucocorticoid prereceptor metabolism and glucocorticoid receptor (GR) protein level were examined in VAT, together with the expression of glucocorticoid-target genes involved in lipid metabolism. The expression of adipogenic and lipogenic transcriptional regulators peroxisome proliferator activated receptor gamma (PPARG) and sterol regulatory element-binding protein 1c (SREBP1c) was also assessed. Results showed disturbed insulin sensitivity in all MIF-/- mice, regardless of the diet. Mice on fructose diet had increased energy intake, but increased visceral adiposity and enlarged adipocytes were observed only in fructose-fed MIF-/- mice. Increased VAT corticosterone level and 11 beta-hydroxysteroid dehydrogenase type 1, hexose-6-phosphate dehydrogenase and GR protein levels were observed in the same animals, together with induced expression of examined lipogenic genes and accumulation of PPARG and SREBP1c. In conclusion, the results showed that dietary fructose was associated with increased visceral adiposity through activation of GR-regulated lipogenic genes, but only in the absence of MIF, which set the state of hyperinsulinemia and insulin resistance.",
journal = "Journal of Molecular Structure",
title = "Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives",
volume = "1181",
doi = "10.1016/j.molstruc.2018.12.083",
pages = "148-156"
}

Petković Cvetković, J., Božić, B. Đ., Banjac, N. R., Petrović, J., Soković, M., Vitnik, V. D., Vitnik, Ž. J., Ušćumlić, G. S.,& Valentić, N. V.. (2019). Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives. in Journal of Molecular Structure, 1181, 148-156.
https://doi.org/10.1016/j.molstruc.2018.12.083

Petković Cvetković J, Božić BĐ, Banjac NR, Petrović J, Soković M, Vitnik VD, Vitnik ŽJ, Ušćumlić GS, Valentić NV. Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives. in Journal of Molecular Structure. 2019;1181:148-156.
doi:10.1016/j.molstruc.2018.12.083 .

Petković Cvetković, Jelena, Božić, Bojan Đ., Banjac, Nebojša R., Petrović, Jovana, Soković, Marina, Vitnik, Vesna D., Vitnik, Željko J., Ušćumlić, Gordana S., Valentić, Nataša V., "Synthesis, antimicrobial activity and quantum chemical investigation of novel succinimide derivatives" in Journal of Molecular Structure, 1181 (2019):148-156,
https://doi.org/10.1016/j.molstruc.2018.12.083 . .