@article{
author = "Žikić, Radoslav V. and Štajn, Andraš Š. and Ognjanović, Branka and Saičić, Zorica and Kostić, Milosav M. and Pavlović, Slađan and Petrović, Vojislav M.",
year = "1998",
abstract = "Two month-old Wistar male albino rats were exposed during a 30-day period to a daily oral intake ad libitum of either 200 Fig/mL Cd (as CdClt), 0.1 Fig/ mL Se (as Na-selenite), or the same dosages of Cd + Se in drinking water. The daily intake from the water was calculated to be 15 mg Cd/kg and 7 kg Se/kg. Cadmium (Cd) accumulates in the heart p < 0.005) and, in rats, decreases both body mass growth p < 0.005) and heart mass (p < 0.02). Selenium (Se) significantly decreases the negative effect of Cd on body mass growth. In the hearts of Cd-treated rats, cadmium caused the decrease (p < 0.05) of selenium-dependent glutathione peroxidase (GSH-Px, EC 1.11.1.9) activity. At the same time, the activities of total superoxide dismutase (total SOD, EC 1.15.1. 1), manganese-containing superoxide dismutase (Mn SOD), and copper-zinc-containing superoxide dismutase (CuZn SOD) were increased (p < 0.005).
The activities of total SOD, CuZn SOD (p < 0.005), GSH-Px (p < 0.02), and glutathione-S-transferase (GST, p < 0.005) were increased in the hearts of Se- treated rats. However, by concomitant administration of Cd and Se, these changes were diminished (total SOD, GST) or were completely eliminated (Mn SOD, GSH-Px). These results indicate that Se only partly diminishes the effects of Cd cardiotoxicity.",
publisher = "Begell House, Inc.",
journal = "Journal of Environmental Pathology, Toxicology and Oncology",
title = "The Effect of Cadmium and Selenium on the Antioxidant Enzyme Activities in Rat Heart",
number = "3-4",
volume = "17",
pages = "259-264",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_5898"
}