TY  - JOUR
AU  - Selaković, Vesna
AU  - Rauš Balind, Snežana
AU  - Radenović, Lidija
AU  - Prolić, Zlatko
AU  - Petković, Branka
PY  - 2013
UR  - https://link.springer.com/article/10.1007/s12013-012-9498-z
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3785
AB  - The aim of study was to investigate the effects of extremely low frequency magnetic field (ELF-MF; 50 Hz; 0.1, 0.25 and 0.5 mT) on oxidative stress in the brain of 3- (adult) and 10-month-old (middle-aged) gerbils. Nitric oxide (NO) level, superoxide (O2-) production, superoxide dismutase (SOD) activity, and index of lipid peroxidation (ILP) were measured in the forebrain cortex, striatum, hippocampus, and cerebellum immediately and 3 days after cessation of 7-day exposure. In all gerbils, ELF-MF significantly increased oxidative stress in all tested brain regions. This effect was correlated with the value of magnetic induction and was higher in middle-aged gerbils. Three days after cessation of exposure, the values of examined parameters were closer to control levels. In adult gerbils, the effect of ELF-MF of 0.1 mT on NO level, O2- production and SOD activity was almost fully disappeared, and ILP was at the control level regardless of the value of magnetic induction. In middle-aged gerbils, the effect of ELF-MF was still present but to a lesser degree than those observed immediately after cessation of exposure. These findings pointed out the ability of ELF-MF to induce age- and magnetic induction-dependent modification of oxidative stress in the brain.
PB  - Humana Press Inc.
T2  - Cell Biochemistry and Biophysics
T1  - Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils
IS  - 3
VL  - 66
DO  - 10.1007/s12013-012-9498-z
SP  - 513
EP  - 521
ER  - 

@article{
author = "Selaković, Vesna and Rauš Balind, Snežana and Radenović, Lidija and Prolić, Zlatko and Petković, Branka",
year = "2013",
abstract = "The aim of study was to investigate the effects of extremely low frequency magnetic field (ELF-MF; 50 Hz; 0.1, 0.25 and 0.5 mT) on oxidative stress in the brain of 3- (adult) and 10-month-old (middle-aged) gerbils. Nitric oxide (NO) level, superoxide (O2-) production, superoxide dismutase (SOD) activity, and index of lipid peroxidation (ILP) were measured in the forebrain cortex, striatum, hippocampus, and cerebellum immediately and 3 days after cessation of 7-day exposure. In all gerbils, ELF-MF significantly increased oxidative stress in all tested brain regions. This effect was correlated with the value of magnetic induction and was higher in middle-aged gerbils. Three days after cessation of exposure, the values of examined parameters were closer to control levels. In adult gerbils, the effect of ELF-MF of 0.1 mT on NO level, O2- production and SOD activity was almost fully disappeared, and ILP was at the control level regardless of the value of magnetic induction. In middle-aged gerbils, the effect of ELF-MF was still present but to a lesser degree than those observed immediately after cessation of exposure. These findings pointed out the ability of ELF-MF to induce age- and magnetic induction-dependent modification of oxidative stress in the brain.",
publisher = "Humana Press Inc.",
journal = "Cell Biochemistry and Biophysics",
title = "Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils",
number = "3",
volume = "66",
doi = "10.1007/s12013-012-9498-z",
pages = "513-521"
}

Selaković, V., Rauš Balind, S., Radenović, L., Prolić, Z.,& Petković, B.. (2013). Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils. in Cell Biochemistry and Biophysics
Humana Press Inc.., 66(3), 513-521.
https://doi.org/10.1007/s12013-012-9498-z

Selaković V, Rauš Balind S, Radenović L, Prolić Z, Petković B. Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils. in Cell Biochemistry and Biophysics. 2013;66(3):513-521.
doi:10.1007/s12013-012-9498-z .

Selaković, Vesna, Rauš Balind, Snežana, Radenović, Lidija, Prolić, Zlatko, Petković, Branka, "Age-Dependent Effects of ELF-MF on Oxidative Stress in the Brain of Mongolian Gerbils" in Cell Biochemistry and Biophysics, 66, no. 3 (2013):513-521,
https://doi.org/10.1007/s12013-012-9498-z . .

TY  - JOUR
AU  - Rauš Balind, Snežana
AU  - Selaković, Vesna
AU  - Manojlović-Stojanoski, Milica
AU  - Radenović, Lidija
AU  - Prolić, Zlatko
AU  - Petković, Branka
PY  - 2013
UR  - https://link.springer.com/article/10.1007/s12640-012-9333-8
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3783
AB  - The purpose of this study was to determine whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects the outcome of postischemic damage in the hippocampus of Mongolian gerbils. After 10-min bilateral carotid occlusion, the gerbils were continuously exposed to ELF-MF (average magnetic induction at the center of the cage was 0.5 mT) for 7 days. The impact of ELF-MF was estimated immediately (the 7th day after reperfusion) and 7 days after cessation of exposure (the 14th day after reperfusion) compared with ischemic gerbils without ELF-MF exposure. Applying stereological methods, histological evaluation of changes in the hippocampus was done for determining its volume, volume densities of degenerating neurons and astrocytes, as well as the number of microglial cells per unit area. ELF-MF per se did not induce any morphological changes, while 10-min global cerebral ischemia led to neuronal death, especially in CA1 region of the hippocampus, as expected. Ischemic gerbils exposed to ELF-MF had significantly a lower degree of cell loss in the examined structure and greater responses of astrocytes and microglial cells than postischemic gerbils without exposure on the seventh day after reperfusion (immediate effect of ELF-MF). Similar response was observed on the 14th day after reperfusion (delayed effect of ELF-MF); however, differences in measured parameters were low and insignificant. Applied ELF-MF has possible neuroprotective function in the hippocampus, as the most sensitive brain structure in the model of global cerebral ischemia, through reduction of neuronal death and activation of astrocytes and microglial cells.
PB  - Springer
T2  - Neurotoxicity Research
T1  - Response of Hippocampal Neurons and Glial Cells to Alternating Magnetic Field in Gerbils Submitted to Global Cerebral Ischemia
IS  - 1
VL  - 23
DO  - 10.1007/s12640-012-9333-8
SP  - 79
EP  - 91
ER  - 

@article{
author = "Rauš Balind, Snežana and Selaković, Vesna and Manojlović-Stojanoski, Milica and Radenović, Lidija and Prolić, Zlatko and Petković, Branka",
year = "2013",
abstract = "The purpose of this study was to determine whether exposure to an extremely low-frequency magnetic field (ELF-MF, 50 Hz) affects the outcome of postischemic damage in the hippocampus of Mongolian gerbils. After 10-min bilateral carotid occlusion, the gerbils were continuously exposed to ELF-MF (average magnetic induction at the center of the cage was 0.5 mT) for 7 days. The impact of ELF-MF was estimated immediately (the 7th day after reperfusion) and 7 days after cessation of exposure (the 14th day after reperfusion) compared with ischemic gerbils without ELF-MF exposure. Applying stereological methods, histological evaluation of changes in the hippocampus was done for determining its volume, volume densities of degenerating neurons and astrocytes, as well as the number of microglial cells per unit area. ELF-MF per se did not induce any morphological changes, while 10-min global cerebral ischemia led to neuronal death, especially in CA1 region of the hippocampus, as expected. Ischemic gerbils exposed to ELF-MF had significantly a lower degree of cell loss in the examined structure and greater responses of astrocytes and microglial cells than postischemic gerbils without exposure on the seventh day after reperfusion (immediate effect of ELF-MF). Similar response was observed on the 14th day after reperfusion (delayed effect of ELF-MF); however, differences in measured parameters were low and insignificant. Applied ELF-MF has possible neuroprotective function in the hippocampus, as the most sensitive brain structure in the model of global cerebral ischemia, through reduction of neuronal death and activation of astrocytes and microglial cells.",
publisher = "Springer",
journal = "Neurotoxicity Research",
title = "Response of Hippocampal Neurons and Glial Cells to Alternating Magnetic Field in Gerbils Submitted to Global Cerebral Ischemia",
number = "1",
volume = "23",
doi = "10.1007/s12640-012-9333-8",
pages = "79-91"
}

Rauš Balind, S., Selaković, V., Manojlović-Stojanoski, M., Radenović, L., Prolić, Z.,& Petković, B.. (2013). Response of Hippocampal Neurons and Glial Cells to Alternating Magnetic Field in Gerbils Submitted to Global Cerebral Ischemia. in Neurotoxicity Research
Springer., 23(1), 79-91.
https://doi.org/10.1007/s12640-012-9333-8

Rauš Balind S, Selaković V, Manojlović-Stojanoski M, Radenović L, Prolić Z, Petković B. Response of Hippocampal Neurons and Glial Cells to Alternating Magnetic Field in Gerbils Submitted to Global Cerebral Ischemia. in Neurotoxicity Research. 2013;23(1):79-91.
doi:10.1007/s12640-012-9333-8 .

Rauš Balind, Snežana, Selaković, Vesna, Manojlović-Stojanoski, Milica, Radenović, Lidija, Prolić, Zlatko, Petković, Branka, "Response of Hippocampal Neurons and Glial Cells to Alternating Magnetic Field in Gerbils Submitted to Global Cerebral Ischemia" in Neurotoxicity Research, 23, no. 1 (2013):79-91,
https://doi.org/10.1007/s12640-012-9333-8 . .

TY  - JOUR
AU  - Petković, Branka
AU  - Selaković, Vesna
AU  - Rauš Balind, Snežana
AU  - Radenović, Lidija
AU  - Zrnić, Mila
AU  - Prolić, Zlatko
PY  - 2012
UR  - https://www.tandfonline.com/doi/full/10.3109/09553002.2012.652725
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3802
AB  - Purpose: The aim of this study was to investigate the influence of extremely low frequency magnetic field (ELF-MF) on different behavior parameters (locomotion, stereotypy, and immobility) in 3- and 10-month-old male Mongolian gerbils. Materials and methods: The animals were continuously exposed to ELF-MF (50 Hz; 0.1, 0.25 and 0.5 mT) for seven days. Their behavior was monitored for 60 min in the open field after the 1st, 2nd, 4th, and 7th day of exposure (immediate effect), and three days after ELF-MF exposure had been ceased (delayed effect). Results : In 3-month-old gerbils, exposure to ELF-MF (0.1, 0.25 and 0.5 mT) increased motor behavior (locomotion and stereotypy), and consequently decreased immobility. Additionally, ELF-MF had delayed effect (except 0.25 mT) on stereotypy and immobility. In 10-month-old gerbils, ELF-MF of 0.1, 0.25 and 0.5 mT induced decrease, slight increase, and pronounced stimulation of motor behavior, respectively. Regardless of magnetic induction value, increased motor behavior was observed three days after ELF-MF exposure has been ceased (delayed effect). Conclusions: It can be proposed that the specific temporal patterns of ELF-MF-induced motor behavior changes in 3- and 10-month-old gerbils are a consequence of age-dependent morpho-functional differences in the brain structures responsible for a control of motor behavior.
PB  - Taylor & Francis Ltd
T2  - International Journal of Radiation Biology
T1  - Temporal patterns of extremely low frequency magnetic field-induced motor behavior changes in Mongolian gerbils of different age
IS  - 4
VL  - 88
DO  - 10.3109/09553002.2012.652725
SP  - 359
EP  - 366
ER  - 

@article{
author = "Petković, Branka and Selaković, Vesna and Rauš Balind, Snežana and Radenović, Lidija and Zrnić, Mila and Prolić, Zlatko",
year = "2012",
abstract = "Purpose: The aim of this study was to investigate the influence of extremely low frequency magnetic field (ELF-MF) on different behavior parameters (locomotion, stereotypy, and immobility) in 3- and 10-month-old male Mongolian gerbils. Materials and methods: The animals were continuously exposed to ELF-MF (50 Hz; 0.1, 0.25 and 0.5 mT) for seven days. Their behavior was monitored for 60 min in the open field after the 1st, 2nd, 4th, and 7th day of exposure (immediate effect), and three days after ELF-MF exposure had been ceased (delayed effect). Results : In 3-month-old gerbils, exposure to ELF-MF (0.1, 0.25 and 0.5 mT) increased motor behavior (locomotion and stereotypy), and consequently decreased immobility. Additionally, ELF-MF had delayed effect (except 0.25 mT) on stereotypy and immobility. In 10-month-old gerbils, ELF-MF of 0.1, 0.25 and 0.5 mT induced decrease, slight increase, and pronounced stimulation of motor behavior, respectively. Regardless of magnetic induction value, increased motor behavior was observed three days after ELF-MF exposure has been ceased (delayed effect). Conclusions: It can be proposed that the specific temporal patterns of ELF-MF-induced motor behavior changes in 3- and 10-month-old gerbils are a consequence of age-dependent morpho-functional differences in the brain structures responsible for a control of motor behavior.",
publisher = "Taylor & Francis Ltd",
journal = "International Journal of Radiation Biology",
title = "Temporal patterns of extremely low frequency magnetic field-induced motor behavior changes in Mongolian gerbils of different age",
number = "4",
volume = "88",
doi = "10.3109/09553002.2012.652725",
pages = "359-366"
}

Petković, B., Selaković, V., Rauš Balind, S., Radenović, L., Zrnić, M.,& Prolić, Z.. (2012). Temporal patterns of extremely low frequency magnetic field-induced motor behavior changes in Mongolian gerbils of different age. in International Journal of Radiation Biology
Taylor & Francis Ltd., 88(4), 359-366.
https://doi.org/10.3109/09553002.2012.652725

Petković B, Selaković V, Rauš Balind S, Radenović L, Zrnić M, Prolić Z. Temporal patterns of extremely low frequency magnetic field-induced motor behavior changes in Mongolian gerbils of different age. in International Journal of Radiation Biology. 2012;88(4):359-366.
doi:10.3109/09553002.2012.652725 .

Petković, Branka, Selaković, Vesna, Rauš Balind, Snežana, Radenović, Lidija, Zrnić, Mila, Prolić, Zlatko, "Temporal patterns of extremely low frequency magnetic field-induced motor behavior changes in Mongolian gerbils of different age" in International Journal of Radiation Biology, 88, no. 4 (2012):359-366,
https://doi.org/10.3109/09553002.2012.652725 . .

TY  - JOUR
AU  - Rauš Balind, Snežana
AU  - Selaković, Vesna
AU  - Radenović, Lidija
AU  - Prolić, Zlatko
AU  - Petković, Branka
PY  - 2012
UR  - https://www.sciencedirect.com/science/article/pii/S0166432811007790?via%3Dihub
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3801
AB  - The purpose of this study was to evaluate behavioural effects of an extremely low frequency magnetic field (ELF-MF) in 3-month-old Mongolian gerbils submitted to global cerebral ischemia. After 10-min occlusion of both common carotid arteries, the gerbils were placed in the vicinity of an electromagnet and continuously exposed to ELF-MF (50 Hz, 0.5 mT) for 7 days. Their behaviour (locomotion, stereotypy, rotations, and immobility) was monitored on days 1, 2, 4, 7, and 14 after reperfusion for 60 min in the open field. It was shown that the 10-min global cerebral ischemia per se induced a significant motor activity increase (locomotion, stereotypy and rotations), and consequently immobility decrease until day 4 after reperfusion, compared to control gerbils. Exposure to ELF-MF inhibited development of ischemia-induced motor hyperactivity during the whole period of registration, but significantly in the first 2 days after reperfusion, when the postischemic hyperactivity was most evident. Motor activity of these gerbils was still significantly increased compared to control ones, but only on day 1 after reperfusion. Our results revealed that the applied ELF-MF (50 Hz, 0.5 mT) decreased motor hyperactivity induced by the 10-min global cerebral ischemia, via modulation of the processes that underlie this behavioural response.
PB  - Elsevier Science BV
T2  - Behavioural Brain Research
T1  - Extremely low frequency magnetic field induced changes in motor behaviour of gerbils submitted to global cerebral ischemia
IS  - 2
VL  - 228
DO  - 10.1016/j.bbr.2011.10.046
SP  - 241
EP  - 246
ER  - 

@article{
author = "Rauš Balind, Snežana and Selaković, Vesna and Radenović, Lidija and Prolić, Zlatko and Petković, Branka",
year = "2012",
abstract = "The purpose of this study was to evaluate behavioural effects of an extremely low frequency magnetic field (ELF-MF) in 3-month-old Mongolian gerbils submitted to global cerebral ischemia. After 10-min occlusion of both common carotid arteries, the gerbils were placed in the vicinity of an electromagnet and continuously exposed to ELF-MF (50 Hz, 0.5 mT) for 7 days. Their behaviour (locomotion, stereotypy, rotations, and immobility) was monitored on days 1, 2, 4, 7, and 14 after reperfusion for 60 min in the open field. It was shown that the 10-min global cerebral ischemia per se induced a significant motor activity increase (locomotion, stereotypy and rotations), and consequently immobility decrease until day 4 after reperfusion, compared to control gerbils. Exposure to ELF-MF inhibited development of ischemia-induced motor hyperactivity during the whole period of registration, but significantly in the first 2 days after reperfusion, when the postischemic hyperactivity was most evident. Motor activity of these gerbils was still significantly increased compared to control ones, but only on day 1 after reperfusion. Our results revealed that the applied ELF-MF (50 Hz, 0.5 mT) decreased motor hyperactivity induced by the 10-min global cerebral ischemia, via modulation of the processes that underlie this behavioural response.",
publisher = "Elsevier Science BV",
journal = "Behavioural Brain Research",
title = "Extremely low frequency magnetic field induced changes in motor behaviour of gerbils submitted to global cerebral ischemia",
number = "2",
volume = "228",
doi = "10.1016/j.bbr.2011.10.046",
pages = "241-246"
}

Rauš Balind, S., Selaković, V., Radenović, L., Prolić, Z.,& Petković, B.. (2012). Extremely low frequency magnetic field induced changes in motor behaviour of gerbils submitted to global cerebral ischemia. in Behavioural Brain Research
Elsevier Science BV., 228(2), 241-246.
https://doi.org/10.1016/j.bbr.2011.10.046

Rauš Balind S, Selaković V, Radenović L, Prolić Z, Petković B. Extremely low frequency magnetic field induced changes in motor behaviour of gerbils submitted to global cerebral ischemia. in Behavioural Brain Research. 2012;228(2):241-246.
doi:10.1016/j.bbr.2011.10.046 .

Rauš Balind, Snežana, Selaković, Vesna, Radenović, Lidija, Prolić, Zlatko, Petković, Branka, "Extremely low frequency magnetic field induced changes in motor behaviour of gerbils submitted to global cerebral ischemia" in Behavioural Brain Research, 228, no. 2 (2012):241-246,
https://doi.org/10.1016/j.bbr.2011.10.046 . .

TY  - JOUR
AU  - Radenović, Lidija
AU  - Selaković, Vesna
AU  - Petković, Branka
AU  - Anđus, Pavle R.
PY  - 2011
UR  - https://akjournals.com/view/journals/036/98/1/article-p32.xml
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3799
AB  - The purpose of this study was to investigate neuroprotective efficiency of N-methyl D-aspartate (NMDA) receptor (NMDAR) blockade on the neuronal damage in the less studied and allegedly less affected CA3 hippocampus and striatum in the Mongolian gerbil model of global cerebral ischemia. The common carotid arteries of gerbils were occluded for 5, 10 or 15 minutes. Gerbils were given a low dose of non-competitive NMDA antagonist (MK-801, 3 mg/kg i.p.) or saline immediately after the occlusion in normothermic conditions. Neuronal damage was examined on 4(th), 14(th) and 28(th) day after reperfusion. The effect of NMDAR blockade was followed in vivo by monitoring the neurological status of whole animals or at the cellular level by standard light- and confocal-microscopy on brain slices. Increased duration of cerebral ischemia resulted in a progressive loss of striatal and CA3 hippocampal neurons. The most beneficial NMDAR blockade effect was observed when the neuronal damage was most severe - on the 28(th) day after 15-min ischemia. As judged by morphological and neurological data, the effect of ischemia is also apparent in the presumed less vulnerable regions (CA3 and striatum) which are functionally important in stroke plasticity. So, NMDAR blockade in normothermic conditions showed neuroprotective efficiency.
PB  - Akadémiai Kiadó Zrt
T2  - Acta Physiologica Hungarica
T1  - Neuroprotective efficiency of NMDA receptor blockade in the striatum and CA3 hippocampus after various durations of cerebral ischemia in gerbils
IS  - 1
VL  - 98
DO  - 10.1556/APhysiol.98.2011.1.5
SP  - 32
EP  - 44
ER  - 

@article{
author = "Radenović, Lidija and Selaković, Vesna and Petković, Branka and Anđus, Pavle R.",
year = "2011",
abstract = "The purpose of this study was to investigate neuroprotective efficiency of N-methyl D-aspartate (NMDA) receptor (NMDAR) blockade on the neuronal damage in the less studied and allegedly less affected CA3 hippocampus and striatum in the Mongolian gerbil model of global cerebral ischemia. The common carotid arteries of gerbils were occluded for 5, 10 or 15 minutes. Gerbils were given a low dose of non-competitive NMDA antagonist (MK-801, 3 mg/kg i.p.) or saline immediately after the occlusion in normothermic conditions. Neuronal damage was examined on 4(th), 14(th) and 28(th) day after reperfusion. The effect of NMDAR blockade was followed in vivo by monitoring the neurological status of whole animals or at the cellular level by standard light- and confocal-microscopy on brain slices. Increased duration of cerebral ischemia resulted in a progressive loss of striatal and CA3 hippocampal neurons. The most beneficial NMDAR blockade effect was observed when the neuronal damage was most severe - on the 28(th) day after 15-min ischemia. As judged by morphological and neurological data, the effect of ischemia is also apparent in the presumed less vulnerable regions (CA3 and striatum) which are functionally important in stroke plasticity. So, NMDAR blockade in normothermic conditions showed neuroprotective efficiency.",
publisher = "Akadémiai Kiadó Zrt",
journal = "Acta Physiologica Hungarica",
title = "Neuroprotective efficiency of NMDA receptor blockade in the striatum and CA3 hippocampus after various durations of cerebral ischemia in gerbils",
number = "1",
volume = "98",
doi = "10.1556/APhysiol.98.2011.1.5",
pages = "32-44"
}

Radenović, L., Selaković, V., Petković, B.,& Anđus, P. R.. (2011). Neuroprotective efficiency of NMDA receptor blockade in the striatum and CA3 hippocampus after various durations of cerebral ischemia in gerbils. in Acta Physiologica Hungarica
Akadémiai Kiadó Zrt., 98(1), 32-44.
https://doi.org/10.1556/APhysiol.98.2011.1.5

Radenović L, Selaković V, Petković B, Anđus PR. Neuroprotective efficiency of NMDA receptor blockade in the striatum and CA3 hippocampus after various durations of cerebral ischemia in gerbils. in Acta Physiologica Hungarica. 2011;98(1):32-44.
doi:10.1556/APhysiol.98.2011.1.5 .

Radenović, Lidija, Selaković, Vesna, Petković, Branka, Anđus, Pavle R., "Neuroprotective efficiency of NMDA receptor blockade in the striatum and CA3 hippocampus after various durations of cerebral ischemia in gerbils" in Acta Physiologica Hungarica, 98, no. 1 (2011):32-44,
https://doi.org/10.1556/APhysiol.98.2011.1.5 . .

TY  - JOUR
AU  - Selaković, Vesna
AU  - Petković, Branka
AU  - Radenović, Lidija
PY  - 2010
UR  - https://link.springer.com/article/10.1007%2Fs11010-010-0466-x
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3797
AB  - We investigated MK-801 effect on ischemia-induced oxidative stress-the most important factor that exacerbates brain damage by reperfusion. The common carotid arteries of gerbils were occluded for 5, 10, or 15 min. Immediately after the occlusion, MK-801 (3 mg/kg i.p.) or saline were given in normothermic conditions. The MK-801 effects were followed in vivo by monitoring the neurological status of animals and at the intracellular level by standard biochemical assays. We investigated nitric oxide levels, superoxide production, superoxide dismutase activity, index of lipid peroxidation (ILP), and reduced glutathione content in hippocampus, striatum, forebrain cortex, and cerebellum. The measurements took place at different times (1, 2, 4, 7, 14, and 28 days) after reperfusion. Increased duration of cerebral ischemia resulted in a progressive induction of oxidative stress. Our results revealed pattern of dynamic changes in each oxidative stress parameter level which corresponded with ischemia duration in all tested brain structures. Most sensitive oxidative stress parameters were ILP and superoxide production. Our study confirmed spatial distribution of ischemia-induced oxidative stress. Tested brain structures showed different sensitivity to each oxidative stress parameter. As judged by biochemical and neurological data, applied MK-801 showed neuroprotective efficiency by reduction of ischemia-induced oxidative stress in brain.
PB  - Springer
T2  - Molecular and Cellular Biochemistry
T1  - MK-801 effect on regional cerebral oxidative stress rate induced by different duration of global ischemia in gerbils
IS  - 1-2
VL  - 342
DO  - 10.1007/s11010-010-0466-x
SP  - 35
EP  - 50
ER  - 

@article{
author = "Selaković, Vesna and Petković, Branka and Radenović, Lidija",
year = "2010",
abstract = "We investigated MK-801 effect on ischemia-induced oxidative stress-the most important factor that exacerbates brain damage by reperfusion. The common carotid arteries of gerbils were occluded for 5, 10, or 15 min. Immediately after the occlusion, MK-801 (3 mg/kg i.p.) or saline were given in normothermic conditions. The MK-801 effects were followed in vivo by monitoring the neurological status of animals and at the intracellular level by standard biochemical assays. We investigated nitric oxide levels, superoxide production, superoxide dismutase activity, index of lipid peroxidation (ILP), and reduced glutathione content in hippocampus, striatum, forebrain cortex, and cerebellum. The measurements took place at different times (1, 2, 4, 7, 14, and 28 days) after reperfusion. Increased duration of cerebral ischemia resulted in a progressive induction of oxidative stress. Our results revealed pattern of dynamic changes in each oxidative stress parameter level which corresponded with ischemia duration in all tested brain structures. Most sensitive oxidative stress parameters were ILP and superoxide production. Our study confirmed spatial distribution of ischemia-induced oxidative stress. Tested brain structures showed different sensitivity to each oxidative stress parameter. As judged by biochemical and neurological data, applied MK-801 showed neuroprotective efficiency by reduction of ischemia-induced oxidative stress in brain.",
publisher = "Springer",
journal = "Molecular and Cellular Biochemistry",
title = "MK-801 effect on regional cerebral oxidative stress rate induced by different duration of global ischemia in gerbils",
number = "1-2",
volume = "342",
doi = "10.1007/s11010-010-0466-x",
pages = "35-50"
}

Selaković, V., Petković, B.,& Radenović, L.. (2010). MK-801 effect on regional cerebral oxidative stress rate induced by different duration of global ischemia in gerbils. in Molecular and Cellular Biochemistry
Springer., 342(1-2), 35-50.
https://doi.org/10.1007/s11010-010-0466-x

Selaković V, Petković B, Radenović L. MK-801 effect on regional cerebral oxidative stress rate induced by different duration of global ischemia in gerbils. in Molecular and Cellular Biochemistry. 2010;342(1-2):35-50.
doi:10.1007/s11010-010-0466-x .

Selaković, Vesna, Petković, Branka, Radenović, Lidija, "MK-801 effect on regional cerebral oxidative stress rate induced by different duration of global ischemia in gerbils" in Molecular and Cellular Biochemistry, 342, no. 1-2 (2010):35-50,
https://doi.org/10.1007/s11010-010-0466-x . .