TY  - JOUR
AU  - Nikolić-Kokić, Aleksandra
AU  - Marinković, Dragan
AU  - Perić, Stojan
AU  - Stević, Zorica
AU  - Spasić, Mihajlo
AU  - Blagojević, Duško
AU  - Rakočević Stojanović, Vidosava
PY  - 2016
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6358
AB  - Objectives: The aim of our study was to determine if redox imbalance caused by the activities of antioxidant
enzymes existed in erythrocytes of type 1 myotonic dystrophy (DM1) patients.
Methods: The activities of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and
glutathione reductase were measured in 30 DM1 patients and 15 healthy controls (HCs). The obtained
values were correlated with the Muscular Impairment Rating Scale (MIRS) score and creatine kinase (CK).
Results: Superoxide dismutase and catalase activities were lower in DM1 patients compared to HCs. A
positive correlation was found between disease duration and MIRS score as well as with glutathione
reductase activity. In DM1 patients, there were positive correlations between catalase, glutathione
peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients according to CK levels,
superoxide dismutase activity was still statistically different from HCs. However, catalase activity was
significantly lower only in DM1 patients with increased CK.
Discussion: Undesirable alterations in antioxidant enzyme activities during DM1 disease progression may
result in conditions favoring oxidative stress and changes in metabolism which together could contribute
to muscle wasting.
PB  - Abingdon: Taylor and Francis
T2  - Redox Report
T1  - Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients
IS  - 5
VL  - 21
DO  - 10.1080/13510002.2015.1107311
SP  - 232
EP  - 237
ER  - 

@article{
author = "Nikolić-Kokić, Aleksandra and Marinković, Dragan and Perić, Stojan and Stević, Zorica and Spasić, Mihajlo and Blagojević, Duško and Rakočević Stojanović, Vidosava",
year = "2016",
abstract = "Objectives: The aim of our study was to determine if redox imbalance caused by the activities of antioxidant
enzymes existed in erythrocytes of type 1 myotonic dystrophy (DM1) patients.
Methods: The activities of erythrocyte superoxide dismutase, catalase, glutathione peroxidase, and
glutathione reductase were measured in 30 DM1 patients and 15 healthy controls (HCs). The obtained
values were correlated with the Muscular Impairment Rating Scale (MIRS) score and creatine kinase (CK).
Results: Superoxide dismutase and catalase activities were lower in DM1 patients compared to HCs. A
positive correlation was found between disease duration and MIRS score as well as with glutathione
reductase activity. In DM1 patients, there were positive correlations between catalase, glutathione
peroxidase, and glutathione reductase activities. After sub-dividing DM1 patients according to CK levels,
superoxide dismutase activity was still statistically different from HCs. However, catalase activity was
significantly lower only in DM1 patients with increased CK.
Discussion: Undesirable alterations in antioxidant enzyme activities during DM1 disease progression may
result in conditions favoring oxidative stress and changes in metabolism which together could contribute
to muscle wasting.",
publisher = "Abingdon: Taylor and Francis",
journal = "Redox Report",
title = "Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients",
number = "5",
volume = "21",
doi = "10.1080/13510002.2015.1107311",
pages = "232-237"
}

Nikolić-Kokić, A., Marinković, D., Perić, S., Stević, Z., Spasić, M., Blagojević, D.,& Rakočević Stojanović, V.. (2016). Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients. in Redox Report
Abingdon: Taylor and Francis., 21(5), 232-237.
https://doi.org/10.1080/13510002.2015.1107311

Nikolić-Kokić A, Marinković D, Perić S, Stević Z, Spasić M, Blagojević D, Rakočević Stojanović V. Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients. in Redox Report. 2016;21(5):232-237.
doi:10.1080/13510002.2015.1107311 .

Nikolić-Kokić, Aleksandra, Marinković, Dragan, Perić, Stojan, Stević, Zorica, Spasić, Mihajlo, Blagojević, Duško, Rakočević Stojanović, Vidosava, "Redox imbalance in peripheral blood of type 1 myotonic dystrophy patients" in Redox Report, 21, no. 5 (2016):232-237,
https://doi.org/10.1080/13510002.2015.1107311 . .

TY  - JOUR
AU  - Nikolić-Kokić, Aleksandra
AU  - Oreščanin-Dušić, Zorana
AU  - Spasojević, Ivan
AU  - Blagojević, Duško
AU  - Stević, Zorica
AU  - Anđus, Pavle
AU  - Spasić, Mihajlo
PY  - 2015
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6080
AB  - In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS.
PB  - Belgrade: Serbian Biological Society
T2  - Archives of Biological Sciences
T1  - The Effects of Wild-Type and Mutant SOD1 on Smooth Muscle Contraction
IS  - 1
VL  - 67
DO  - 10.2298/ABS141006023N
SP  - 187
EP  - 192
ER  - 

@article{
author = "Nikolić-Kokić, Aleksandra and Oreščanin-Dušić, Zorana and Spasojević, Ivan and Blagojević, Duško and Stević, Zorica and Anđus, Pavle and Spasić, Mihajlo",
year = "2015",
abstract = "In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS.",
publisher = "Belgrade: Serbian Biological Society",
journal = "Archives of Biological Sciences",
title = "The Effects of Wild-Type and Mutant SOD1 on Smooth Muscle Contraction",
number = "1",
volume = "67",
doi = "10.2298/ABS141006023N",
pages = "187-192"
}

Nikolić-Kokić, A., Oreščanin-Dušić, Z., Spasojević, I., Blagojević, D., Stević, Z., Anđus, P.,& Spasić, M.. (2015). The Effects of Wild-Type and Mutant SOD1 on Smooth Muscle Contraction. in Archives of Biological Sciences
Belgrade: Serbian Biological Society., 67(1), 187-192.
https://doi.org/10.2298/ABS141006023N

Nikolić-Kokić A, Oreščanin-Dušić Z, Spasojević I, Blagojević D, Stević Z, Anđus P, Spasić M. The Effects of Wild-Type and Mutant SOD1 on Smooth Muscle Contraction. in Archives of Biological Sciences. 2015;67(1):187-192.
doi:10.2298/ABS141006023N .

Nikolić-Kokić, Aleksandra, Oreščanin-Dušić, Zorana, Spasojević, Ivan, Blagojević, Duško, Stević, Zorica, Anđus, Pavle, Spasić, Mihajlo, "The Effects of Wild-Type and Mutant SOD1 on Smooth Muscle Contraction" in Archives of Biological Sciences, 67, no. 1 (2015):187-192,
https://doi.org/10.2298/ABS141006023N . .