TY  - JOUR
AU  - Blagojević, Duško
AU  - Grubor-Lajšić, Gordana
AU  - Spasić, Mihajlo
PY  - 2011
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4053
AB  - Low temperatures provoke increased production of heat accompanied by increased respiration, oxygen consumption and the production of partially reduced oxygen species called ROS. ROS induce different forms of cellular oxidative damage, disturb the redox state and can change the activity of several metabolic enzymes. Organisms have developed a functionally connected set of anti-oxidant enzymes and low molecular mass compounds (together termed the ADS) that metabolise primary ROS. If ROS production within cells overwhelms the ADS, oxidative damage arises and oxidative stress can occur. Short-term cold exposure in endotherms leads to oxidative stress. As cold exposure persists organisms develop adaptive changes toward reducing ROS production and increasing the ADS. In contrast, heterotherms and ectotherms as a normal part of their over-wintering strategy slow down metabolism, oxygen consumption and subsequently cause ROS production. Increased baseline activity of key anti-oxidant enzymes as well as 'secondary' enzymatic defence and/or glutathione levels in preparation for a putative oxidative stressful situation arising from tissue re-oxygenation seems to be the preferred evolutionary adaptation of such animals exposed to low environmental temperatures.
PB  - Frontiers in Bioscience
T2  - Frontiers in bioscience (Scholar edition)
T1  - Cold defence responses: The role of oxidative stress
IS  - 2
VL  - 3
DO  - 10.2741/s161
SP  - 416
EP  - 417
ER  - 

@article{
author = "Blagojević, Duško and Grubor-Lajšić, Gordana and Spasić, Mihajlo",
year = "2011",
abstract = "Low temperatures provoke increased production of heat accompanied by increased respiration, oxygen consumption and the production of partially reduced oxygen species called ROS. ROS induce different forms of cellular oxidative damage, disturb the redox state and can change the activity of several metabolic enzymes. Organisms have developed a functionally connected set of anti-oxidant enzymes and low molecular mass compounds (together termed the ADS) that metabolise primary ROS. If ROS production within cells overwhelms the ADS, oxidative damage arises and oxidative stress can occur. Short-term cold exposure in endotherms leads to oxidative stress. As cold exposure persists organisms develop adaptive changes toward reducing ROS production and increasing the ADS. In contrast, heterotherms and ectotherms as a normal part of their over-wintering strategy slow down metabolism, oxygen consumption and subsequently cause ROS production. Increased baseline activity of key anti-oxidant enzymes as well as 'secondary' enzymatic defence and/or glutathione levels in preparation for a putative oxidative stressful situation arising from tissue re-oxygenation seems to be the preferred evolutionary adaptation of such animals exposed to low environmental temperatures.",
publisher = "Frontiers in Bioscience",
journal = "Frontiers in bioscience (Scholar edition)",
title = "Cold defence responses: The role of oxidative stress",
number = "2",
volume = "3",
doi = "10.2741/s161",
pages = "416-417"
}

Blagojević, D., Grubor-Lajšić, G.,& Spasić, M.. (2011). Cold defence responses: The role of oxidative stress. in Frontiers in bioscience (Scholar edition)
Frontiers in Bioscience., 3(2), 416-417.
https://doi.org/10.2741/s161

Blagojević D, Grubor-Lajšić G, Spasić M. Cold defence responses: The role of oxidative stress. in Frontiers in bioscience (Scholar edition). 2011;3(2):416-417.
doi:10.2741/s161 .

Blagojević, Duško, Grubor-Lajšić, Gordana, Spasić, Mihajlo, "Cold defence responses: The role of oxidative stress" in Frontiers in bioscience (Scholar edition), 3, no. 2 (2011):416-417,
https://doi.org/10.2741/s161 . .