TY  - JOUR
AU  - Katanić Stanković, Jelena S.
AU  - Đorović Jovanović, Jelena
AU  - Mišić, Danijela
AU  - Gašić, Uroš
AU  - Nikles, Stefanie
AU  - Marković, Zoran
AU  - Bauer, Rudolf
PY  - 2023
UR  - https://www.mdpi.com/1420-3049/28/3/1274
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9921532
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5482
AB  - Rabelera holostea (L.) M. T. Sharples & E. A. Tripp (Greater Stitchwort), formerly known as Stellaria holostea L., is widespread in the warm temperate areas of Europe and Western Asia, the Caucasus region, as well as in some countries of North Africa. Nowadays it is considered as a weed, but earlier it was often used raw in salads or for the treatment of various inflammatory disorders. The goal of this study was to determine the constituents of the methanol extract of R. holostea aerial parts and its biological potential in terms of antioxidant, antimicrobial, and anti-inflammatory properties. Until now, the constituents and biological activities of this plant were not reported in detail. A comprehensive phytochemical profiling of the extract has shown that phenolic acids, such as ferulic, chlorogenic, and p-coumaric acid, flavonoids and flavonoid glucosides, such as chrysoeriol, rutin, and naringin, are the most abundant compounds. The antioxidant activity of R. holostea extract towards DPPH and ABTS radicals, but also the total antioxidant capacity and the inhibition of lipid peroxidation were moderate. The antimicrobial potential was pronounced mostly towards some fungi such as F. oxysporum (MIC 1.25 mg/mL), whereas the capacity of R. holostea to affect the growth of bacteria was much less pronounced. R. holostea extract was most inclined to anti-inflammatory activity. At a concentration of 50 µg/mL, it significantly inhibited both cyclooxygenase enzymes (COX-1 and COX-2) by 71.24% and 72.83%, respectively. Molecular docking studies indicated that chlorogenic acid and chrysoeriol are the main contributors to COX-1 and COX-2 inhibitory activity.
PB  - Basel: MDPI
T2  - Molecules (Basel, Switzerland)
T1  - UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract
IS  - 3
VL  - 28
DO  - 10.3390/molecules28031274
SP  - 1274
ER  - 

@article{
author = "Katanić Stanković, Jelena S. and Đorović Jovanović, Jelena and Mišić, Danijela and Gašić, Uroš and Nikles, Stefanie and Marković, Zoran and Bauer, Rudolf",
year = "2023",
abstract = "Rabelera holostea (L.) M. T. Sharples & E. A. Tripp (Greater Stitchwort), formerly known as Stellaria holostea L., is widespread in the warm temperate areas of Europe and Western Asia, the Caucasus region, as well as in some countries of North Africa. Nowadays it is considered as a weed, but earlier it was often used raw in salads or for the treatment of various inflammatory disorders. The goal of this study was to determine the constituents of the methanol extract of R. holostea aerial parts and its biological potential in terms of antioxidant, antimicrobial, and anti-inflammatory properties. Until now, the constituents and biological activities of this plant were not reported in detail. A comprehensive phytochemical profiling of the extract has shown that phenolic acids, such as ferulic, chlorogenic, and p-coumaric acid, flavonoids and flavonoid glucosides, such as chrysoeriol, rutin, and naringin, are the most abundant compounds. The antioxidant activity of R. holostea extract towards DPPH and ABTS radicals, but also the total antioxidant capacity and the inhibition of lipid peroxidation were moderate. The antimicrobial potential was pronounced mostly towards some fungi such as F. oxysporum (MIC 1.25 mg/mL), whereas the capacity of R. holostea to affect the growth of bacteria was much less pronounced. R. holostea extract was most inclined to anti-inflammatory activity. At a concentration of 50 µg/mL, it significantly inhibited both cyclooxygenase enzymes (COX-1 and COX-2) by 71.24% and 72.83%, respectively. Molecular docking studies indicated that chlorogenic acid and chrysoeriol are the main contributors to COX-1 and COX-2 inhibitory activity.",
publisher = "Basel: MDPI",
journal = "Molecules (Basel, Switzerland)",
title = "UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract",
number = "3",
volume = "28",
doi = "10.3390/molecules28031274",
pages = "1274"
}

Katanić Stanković, J. S., Đorović Jovanović, J., Mišić, D., Gašić, U., Nikles, S., Marković, Z.,& Bauer, R.. (2023). UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract. in Molecules (Basel, Switzerland)
Basel: MDPI., 28(3), 1274.
https://doi.org/10.3390/molecules28031274

Katanić Stanković JS, Đorović Jovanović J, Mišić D, Gašić U, Nikles S, Marković Z, Bauer R. UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract. in Molecules (Basel, Switzerland). 2023;28(3):1274.
doi:10.3390/molecules28031274 .

Katanić Stanković, Jelena S., Đorović Jovanović, Jelena, Mišić, Danijela, Gašić, Uroš, Nikles, Stefanie, Marković, Zoran, Bauer, Rudolf, "UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract" in Molecules (Basel, Switzerland), 28, no. 3 (2023):1274,
https://doi.org/10.3390/molecules28031274 . .