TY  - JOUR
AU  - Miljković, Đorđe
AU  - Stanisavljević, Suzana
AU  - Jensen, Isaac J
AU  - Griffith, Thomas S
AU  - Badovinac, Vladimir P
PY  - 2021
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0165247821001176
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/4455
AB  - Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.
PB  - Amsterdam: Elsevier B.V.
T2  - Immunology Letters
T1  - Sepsis and multiple sclerosis: Causative links and outcomes
VL  - 238
DO  - 10.1016/j.imlet.2021.07.008
SP  - 40
EP  - 46
ER  - 

@article{
author = "Miljković, Đorđe and Stanisavljević, Suzana and Jensen, Isaac J and Griffith, Thomas S and Badovinac, Vladimir P",
year = "2021",
abstract = "Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.",
publisher = "Amsterdam: Elsevier B.V.",
journal = "Immunology Letters",
title = "Sepsis and multiple sclerosis: Causative links and outcomes",
volume = "238",
doi = "10.1016/j.imlet.2021.07.008",
pages = "40-46"
}

Miljković, Đ., Stanisavljević, S., Jensen, I. J., Griffith, T. S.,& Badovinac, V. P.. (2021). Sepsis and multiple sclerosis: Causative links and outcomes. in Immunology Letters
Amsterdam: Elsevier B.V.., 238, 40-46.
https://doi.org/10.1016/j.imlet.2021.07.008

Miljković Đ, Stanisavljević S, Jensen IJ, Griffith TS, Badovinac VP. Sepsis and multiple sclerosis: Causative links and outcomes. in Immunology Letters. 2021;238:40-46.
doi:10.1016/j.imlet.2021.07.008 .

Miljković, Đorđe, Stanisavljević, Suzana, Jensen, Isaac J, Griffith, Thomas S, Badovinac, Vladimir P, "Sepsis and multiple sclerosis: Causative links and outcomes" in Immunology Letters, 238 (2021):40-46,
https://doi.org/10.1016/j.imlet.2021.07.008 . .