TY  - JOUR
AU  - Useini, Liridona
AU  - Mojić, Marija
AU  - Laube, Markus
AU  - Lönnecke, Peter
AU  - Dahme, Jonas
AU  - Sárosi, Menyhárt B.
AU  - Mijatović, Sanja
AU  - Maksimović-Ivanić, Danijela
AU  - Pietzsch, Jens
AU  - Hey-Hawkins, Evamarie
PY  - 2022
UR  - https://pubs.acs.org/doi/10.1021/acsomega.2c01523
UR  - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9301635
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5075
AB  - Mefenamic acid represents a widely used nonsteroidal anti-inflammatory drug (NSAID) to treat the pain of postoperative surgery and heavy menstrual bleeding. Like other NSAIDs, mefenamic acid inhibits the synthesis of prostaglandins by nonselectively blocking cyclooxygenase (COX) isoforms COX-1 and COX-2. For the improved selectivity of the drug and, therefore, reduced related side effects, the carborane analogues of mefenamic acid were evaluated. The ortho-, meta-, and para-carborane derivatives were synthesized in three steps: halogenation of the respective cluster, followed by a Pd-catalyzed B-N coupling and hydrolysis of the nitrile derivatives under acidic conditions. The COX inhibitory activity and cytotoxicity for different cancer cell lines revealed that the carborane analogues have stronger antitumor potential compared to their parent organic compound.
PB  - Washington: American Chemical Society
T2  - ACS Omega
T1  - Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation.
IS  - 28
VL  - 7
DO  - 10.1021/acsomega.2c01523
SP  - 24282
EP  - 24291
ER  - 

@article{
author = "Useini, Liridona and Mojić, Marija and Laube, Markus and Lönnecke, Peter and Dahme, Jonas and Sárosi, Menyhárt B. and Mijatović, Sanja and Maksimović-Ivanić, Danijela and Pietzsch, Jens and Hey-Hawkins, Evamarie",
year = "2022",
abstract = "Mefenamic acid represents a widely used nonsteroidal anti-inflammatory drug (NSAID) to treat the pain of postoperative surgery and heavy menstrual bleeding. Like other NSAIDs, mefenamic acid inhibits the synthesis of prostaglandins by nonselectively blocking cyclooxygenase (COX) isoforms COX-1 and COX-2. For the improved selectivity of the drug and, therefore, reduced related side effects, the carborane analogues of mefenamic acid were evaluated. The ortho-, meta-, and para-carborane derivatives were synthesized in three steps: halogenation of the respective cluster, followed by a Pd-catalyzed B-N coupling and hydrolysis of the nitrile derivatives under acidic conditions. The COX inhibitory activity and cytotoxicity for different cancer cell lines revealed that the carborane analogues have stronger antitumor potential compared to their parent organic compound.",
publisher = "Washington: American Chemical Society",
journal = "ACS Omega",
title = "Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation.",
number = "28",
volume = "7",
doi = "10.1021/acsomega.2c01523",
pages = "24282-24291"
}

Useini, L., Mojić, M., Laube, M., Lönnecke, P., Dahme, J., Sárosi, M. B., Mijatović, S., Maksimović-Ivanić, D., Pietzsch, J.,& Hey-Hawkins, E.. (2022). Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation.. in ACS Omega
Washington: American Chemical Society., 7(28), 24282-24291.
https://doi.org/10.1021/acsomega.2c01523

Useini L, Mojić M, Laube M, Lönnecke P, Dahme J, Sárosi MB, Mijatović S, Maksimović-Ivanić D, Pietzsch J, Hey-Hawkins E. Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation.. in ACS Omega. 2022;7(28):24282-24291.
doi:10.1021/acsomega.2c01523 .

Useini, Liridona, Mojić, Marija, Laube, Markus, Lönnecke, Peter, Dahme, Jonas, Sárosi, Menyhárt B., Mijatović, Sanja, Maksimović-Ivanić, Danijela, Pietzsch, Jens, Hey-Hawkins, Evamarie, "Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation." in ACS Omega, 7, no. 28 (2022):24282-24291,
https://doi.org/10.1021/acsomega.2c01523 . .