TY  - JOUR
AU  - Janković, Aleksandra
AU  - Korać, Aleksandra
AU  - Buzadžić, Biljana
AU  - Stančić, Ana
AU  - Otašević, Vesna
AU  - Ferdinandy, Peter
AU  - Daiber, Andreas
AU  - Korać, Bato
PY  - 2017
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6734
AB  - Insulin sensitivity and metabolic homeostasis depend on the capacity of adipose tissue to take up and utilize excess glucose and fatty acids. The key aspects that determine the fuel‐buffering capacity of adipose tissue depend on the physiological levels of the small redox molecule, nitric oxide (NO). In addition to impairment of NO synthesis, excessive formation of the superoxide anion (О2 •–) in adipose tissue may be an important interfering factor diverting the signalling of NO and other reactive oxygen and nitrogen species in obesity, resulting in metabolic dysfunction of adipose tissue over time. Besides its role in relief from superoxide burst, enhanced NO signalling may be responsible for the therapeutic benefits of different superoxide dismutase mimetics, in obesity and experimental diabetes models. This review summarizes the role of NO in adipose tissue and highlights the effects of NO/О2 •– ratio ‘teetering’ as a promising pharmacological target in the metabolic syndrome.
PB  - John Wiley & Sons, Inc
T2  - British Journal of Pharmacology
T1  - Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management
IS  - 12
VL  - 174
DO  - 10.1111/bph.13498
SP  - 1570
EP  - 1590
ER  - 

@article{
author = "Janković, Aleksandra and Korać, Aleksandra and Buzadžić, Biljana and Stančić, Ana and Otašević, Vesna and Ferdinandy, Peter and Daiber, Andreas and Korać, Bato",
year = "2017",
abstract = "Insulin sensitivity and metabolic homeostasis depend on the capacity of adipose tissue to take up and utilize excess glucose and fatty acids. The key aspects that determine the fuel‐buffering capacity of adipose tissue depend on the physiological levels of the small redox molecule, nitric oxide (NO). In addition to impairment of NO synthesis, excessive formation of the superoxide anion (О2 •–) in adipose tissue may be an important interfering factor diverting the signalling of NO and other reactive oxygen and nitrogen species in obesity, resulting in metabolic dysfunction of adipose tissue over time. Besides its role in relief from superoxide burst, enhanced NO signalling may be responsible for the therapeutic benefits of different superoxide dismutase mimetics, in obesity and experimental diabetes models. This review summarizes the role of NO in adipose tissue and highlights the effects of NO/О2 •– ratio ‘teetering’ as a promising pharmacological target in the metabolic syndrome.",
publisher = "John Wiley & Sons, Inc",
journal = "British Journal of Pharmacology",
title = "Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management",
number = "12",
volume = "174",
doi = "10.1111/bph.13498",
pages = "1570-1590"
}

Janković, A., Korać, A., Buzadžić, B., Stančić, A., Otašević, V., Ferdinandy, P., Daiber, A.,& Korać, B.. (2017). Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management. in British Journal of Pharmacology
John Wiley & Sons, Inc., 174(12), 1570-1590.
https://doi.org/10.1111/bph.13498

Janković A, Korać A, Buzadžić B, Stančić A, Otašević V, Ferdinandy P, Daiber A, Korać B. Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management. in British Journal of Pharmacology. 2017;174(12):1570-1590.
doi:10.1111/bph.13498 .

Janković, Aleksandra, Korać, Aleksandra, Buzadžić, Biljana, Stančić, Ana, Otašević, Vesna, Ferdinandy, Peter, Daiber, Andreas, Korać, Bato, "Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management" in British Journal of Pharmacology, 174, no. 12 (2017):1570-1590,
https://doi.org/10.1111/bph.13498 . .