TY  - JOUR
AU  - Lopes, Catarina L
AU  - Pereira, Eliana
AU  - Soković, Marina
AU  - Carvalho, Ana Maria
AU  - Barata, Ana Maria
AU  - Lopes, Violeta
AU  - Rocha, Filomena
AU  - Calhelha, Ricardo C
AU  - Barros, Lillian
AU  - Ferreira, Isabel C F R
PY  - 2018
UR  - http://www.mdpi.com/1420-3049/23/5/1037
UR  - http://www.ncbi.nlm.nih.gov/pubmed/29710781
UR  - https://radar.ibiss.bg.ac.rs/handle/123456789/3058
AB  - The aim of this study was to characterize the phenolic composition and evaluate the bioactivity of several samples of Lavandula pedunculata (Mill.) Cav, and to compare aqueous and hydroethanolic extracts. Plant materials were obtained by growing some accessions (seed samples) of various wild populations from different regions of Portugal conserved at the Portuguese Genebank in Braga. Phenolic compounds were analised by HPLC-DAD-ESI/MSn, antioxidant potential through in vitro assays (DPPH radical scavenging activity, reducing power and inhibition of lipid peroxidation), cytotoxicity on tumor cells (MCF-7, NCI-H460, HeLa and HepG2) and non-tumor (PLP2) cells, anti-inflammatory activity in rat RAW 264.7 macrophages, by the ability to inhibit NO production and antimicrobial potential by the microdilution method with INT dye (iodonitrotetrazolium chloride). Thirteen compounds were identified, being salvianolic acid B, rosmarinic acid and luteolin-7-O-glucuronide, the main compounds present, with values ranging between 44.3⁻582, 50.9⁻550, and 24.36⁻101.5 mg/g extract, respectively. L. pedunculata aqueous extract revealed a higher antioxidant potential (EC50 values between 14 to 530 μg/mL), which could be related to its higher concentration in phenolic compounds; however, the hydroethanolic extract showed a higher anti-inflammatory (lower EC50 values than 124 μg/mL) potential and antiproliferative capacity (lower GI50 values than 34 μg/mL). Thus, this study highlights the bioactive effects of this species and opens up possibilities of uses in food and pharmaceutical formulations. However, there are potential differences in such properties according to geographical origin of plant material, as in general, the samples from Alentejo presented higher results in all the bioactivities, compared with Trás-os-Montes samples.
T2  - Molecules (Basel, Switzerland)
T1  - Phenolic Composition and Bioactivity of Lavandula pedunculata (Mill.) Cav. Samples from Different Geographical Origin.
IS  - 5
VL  - 23
DO  - 10.3390/molecules23051037
SP  - 1037
ER  - 

@article{
author = "Lopes, Catarina L and Pereira, Eliana and Soković, Marina and Carvalho, Ana Maria and Barata, Ana Maria and Lopes, Violeta and Rocha, Filomena and Calhelha, Ricardo C and Barros, Lillian and Ferreira, Isabel C F R",
year = "2018",
abstract = "The aim of this study was to characterize the phenolic composition and evaluate the bioactivity of several samples of Lavandula pedunculata (Mill.) Cav, and to compare aqueous and hydroethanolic extracts. Plant materials were obtained by growing some accessions (seed samples) of various wild populations from different regions of Portugal conserved at the Portuguese Genebank in Braga. Phenolic compounds were analised by HPLC-DAD-ESI/MSn, antioxidant potential through in vitro assays (DPPH radical scavenging activity, reducing power and inhibition of lipid peroxidation), cytotoxicity on tumor cells (MCF-7, NCI-H460, HeLa and HepG2) and non-tumor (PLP2) cells, anti-inflammatory activity in rat RAW 264.7 macrophages, by the ability to inhibit NO production and antimicrobial potential by the microdilution method with INT dye (iodonitrotetrazolium chloride). Thirteen compounds were identified, being salvianolic acid B, rosmarinic acid and luteolin-7-O-glucuronide, the main compounds present, with values ranging between 44.3⁻582, 50.9⁻550, and 24.36⁻101.5 mg/g extract, respectively. L. pedunculata aqueous extract revealed a higher antioxidant potential (EC50 values between 14 to 530 μg/mL), which could be related to its higher concentration in phenolic compounds; however, the hydroethanolic extract showed a higher anti-inflammatory (lower EC50 values than 124 μg/mL) potential and antiproliferative capacity (lower GI50 values than 34 μg/mL). Thus, this study highlights the bioactive effects of this species and opens up possibilities of uses in food and pharmaceutical formulations. However, there are potential differences in such properties according to geographical origin of plant material, as in general, the samples from Alentejo presented higher results in all the bioactivities, compared with Trás-os-Montes samples.",
journal = "Molecules (Basel, Switzerland)",
title = "Phenolic Composition and Bioactivity of Lavandula pedunculata (Mill.) Cav. Samples from Different Geographical Origin.",
number = "5",
volume = "23",
doi = "10.3390/molecules23051037",
pages = "1037"
}

Lopes, C. L., Pereira, E., Soković, M., Carvalho, A. M., Barata, A. M., Lopes, V., Rocha, F., Calhelha, R. C., Barros, L.,& Ferreira, I. C. F. R.. (2018). Phenolic Composition and Bioactivity of Lavandula pedunculata (Mill.) Cav. Samples from Different Geographical Origin.. in Molecules (Basel, Switzerland), 23(5), 1037.
https://doi.org/10.3390/molecules23051037

Lopes CL, Pereira E, Soković M, Carvalho AM, Barata AM, Lopes V, Rocha F, Calhelha RC, Barros L, Ferreira ICFR. Phenolic Composition and Bioactivity of Lavandula pedunculata (Mill.) Cav. Samples from Different Geographical Origin.. in Molecules (Basel, Switzerland). 2018;23(5):1037.
doi:10.3390/molecules23051037 .

Lopes, Catarina L, Pereira, Eliana, Soković, Marina, Carvalho, Ana Maria, Barata, Ana Maria, Lopes, Violeta, Rocha, Filomena, Calhelha, Ricardo C, Barros, Lillian, Ferreira, Isabel C F R, "Phenolic Composition and Bioactivity of Lavandula pedunculata (Mill.) Cav. Samples from Different Geographical Origin." in Molecules (Basel, Switzerland), 23, no. 5 (2018):1037,
https://doi.org/10.3390/molecules23051037 . .