TY  - JOUR
AU  - Patenković, Aleksandra
AU  - Stamenković-Radak, Marina
AU  - Banjanac, Tijana
AU  - Anđelković, Marko
PY  - 2009
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/5531
AB  - The present study assayed the antimutagenic potential of Salvia officinalis (sage) in the form of tea infusion, by the somatic mutation and recombination test (SMART) on Drosophila melanogaster. The use of herbal infusions is much common in the human diet, so the aim of the present study was to estimate the antimutagenic effects of the S. officinalis tea rather than essential oils. Methyl methanesulphonate (MMS) was used as the mutagen and positive control. Several types of treatment were performed: short acute treatment with sage infusion or MMS, longer (chronic) treatment with sage solution or MMS, and two combined treatments, i.e. short treatment with sage followed by a longer treatment with MMS and vice versa. Sage infusion used in our experiments showed a clear antimutagenic effect, reducing the frequency of mutations induced by MMS. The inhibition effect of sage tea is obtained and confirmed when pre- or post-treatments with mutagen were used. The results indicate that although sage in this regime decreases the number of mutation events, it is not efficient enough in case of the 2 h sage pre-treatment. Antioxidant activity, suppression of metabolic activation, could be mechanisms through which sage or some of its components act as desmutagen.
PB  - Oxford, UK: Pergamon-Elsevier Science Ltd.
T2  - Food and Chemical Toxicology
T1  - Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster
IS  - 1
VL  - 47
DO  - 10.1016/j.fct.2008.10.024
SP  - 180
EP  - 183
ER  - 

@article{
author = "Patenković, Aleksandra and Stamenković-Radak, Marina and Banjanac, Tijana and Anđelković, Marko",
year = "2009",
abstract = "The present study assayed the antimutagenic potential of Salvia officinalis (sage) in the form of tea infusion, by the somatic mutation and recombination test (SMART) on Drosophila melanogaster. The use of herbal infusions is much common in the human diet, so the aim of the present study was to estimate the antimutagenic effects of the S. officinalis tea rather than essential oils. Methyl methanesulphonate (MMS) was used as the mutagen and positive control. Several types of treatment were performed: short acute treatment with sage infusion or MMS, longer (chronic) treatment with sage solution or MMS, and two combined treatments, i.e. short treatment with sage followed by a longer treatment with MMS and vice versa. Sage infusion used in our experiments showed a clear antimutagenic effect, reducing the frequency of mutations induced by MMS. The inhibition effect of sage tea is obtained and confirmed when pre- or post-treatments with mutagen were used. The results indicate that although sage in this regime decreases the number of mutation events, it is not efficient enough in case of the 2 h sage pre-treatment. Antioxidant activity, suppression of metabolic activation, could be mechanisms through which sage or some of its components act as desmutagen.",
publisher = "Oxford, UK: Pergamon-Elsevier Science Ltd.",
journal = "Food and Chemical Toxicology",
title = "Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster",
number = "1",
volume = "47",
doi = "10.1016/j.fct.2008.10.024",
pages = "180-183"
}

Patenković, A., Stamenković-Radak, M., Banjanac, T.,& Anđelković, M.. (2009). Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster. in Food and Chemical Toxicology
Oxford, UK: Pergamon-Elsevier Science Ltd.., 47(1), 180-183.
https://doi.org/10.1016/j.fct.2008.10.024

Patenković A, Stamenković-Radak M, Banjanac T, Anđelković M. Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster. in Food and Chemical Toxicology. 2009;47(1):180-183.
doi:10.1016/j.fct.2008.10.024 .

Patenković, Aleksandra, Stamenković-Radak, Marina, Banjanac, Tijana, Anđelković, Marko, "Antimutagenic effect of sage tea in the wing spot test of Drosophila melanogaster" in Food and Chemical Toxicology, 47, no. 1 (2009):180-183,
https://doi.org/10.1016/j.fct.2008.10.024 . .