TY  - DATA
AU  - Dinić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Uskoković, Aleksandra
AU  - Jovanović, Aleksandra
AU  - Grdović, Nevena
AU  - Rajić, Jovana
AU  - Đorđević, Marija
AU  - Sarić, Ana
AU  - Bugarski, Branko
AU  - Vidaković, Melita
AU  - Mihailović, Mirjana
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6982
AB  - This dataset is a supplementary document of the research article:Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin. It contains Table S1 with data about Encapsulation efficiency (EE), vesicle size, polydispersity index (PDI), zeta potential, and mobility of silibinin-loaded liposomes measured immediately after the preparation. Figure S1 is graphical presentation of silibinin-loaded liposome (A) size distribution by volume, (B) size distribution by intensity, (C) zeta potential distribution, and (D) mobility distribution measured using photon correlation spectroscopy (dynamic light scattering).
T1  - Supplementary data for the article: Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin
UR  - https://hdl.handle.net/21.15107/rcub_ibiss_6982
ER  - 

@misc{
author = "Dinić, Svetlana and Arambašić Jovanović, Jelena and Uskoković, Aleksandra and Jovanović, Aleksandra and Grdović, Nevena and Rajić, Jovana and Đorđević, Marija and Sarić, Ana and Bugarski, Branko and Vidaković, Melita and Mihailović, Mirjana",
year = "2024",
abstract = "This dataset is a supplementary document of the research article:Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin. It contains Table S1 with data about Encapsulation efficiency (EE), vesicle size, polydispersity index (PDI), zeta potential, and mobility of silibinin-loaded liposomes measured immediately after the preparation. Figure S1 is graphical presentation of silibinin-loaded liposome (A) size distribution by volume, (B) size distribution by intensity, (C) zeta potential distribution, and (D) mobility distribution measured using photon correlation spectroscopy (dynamic light scattering).",
title = "Supplementary data for the article: Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin",
url = "https://hdl.handle.net/21.15107/rcub_ibiss_6982"
}

Dinić, S., Arambašić Jovanović, J., Uskoković, A., Jovanović, A., Grdović, N., Rajić, J., Đorđević, M., Sarić, A., Bugarski, B., Vidaković, M.,& Mihailović, M.. (2024). Supplementary data for the article: Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin. .
https://hdl.handle.net/21.15107/rcub_ibiss_6982

Dinić S, Arambašić Jovanović J, Uskoković A, Jovanović A, Grdović N, Rajić J, Đorđević M, Sarić A, Bugarski B, Vidaković M, Mihailović M. Supplementary data for the article: Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin. 2024;.
https://hdl.handle.net/21.15107/rcub_ibiss_6982 .

Dinić, Svetlana, Arambašić Jovanović, Jelena, Uskoković, Aleksandra, Jovanović, Aleksandra, Grdović, Nevena, Rajić, Jovana, Đorđević, Marija, Sarić, Ana, Bugarski, Branko, Vidaković, Melita, Mihailović, Mirjana, "Supplementary data for the article: Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin" (2024),
https://hdl.handle.net/21.15107/rcub_ibiss_6982 .

TY  - JOUR
AU  - Dinić, Svetlana
AU  - Arambašić Jovanović, Jelena
AU  - Uskoković, Aleksandra
AU  - Jovanović, Aleksandra
AU  - Grdović, Nevena
AU  - Rajić, Jovana
AU  - Đorđević, Marija
AU  - Sarić, Ana
AU  - Bugarski, Branko
AU  - Vidaković, Melita
AU  - Mihailović, Mirjana
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6856
AB  - Silibinin has considerable therapeutic potential for the treatment of diabetes through anti-inflammatory, antioxidant, and immunomodulatory properties. However, the therapeutic application of silibinin is quite limited due to its poor bioavailability. In the present study, an attempt was made to improve the antidiabetic efficacy of silibinin by its encapsulation in liposomal vesicles. The liposomes with a high encapsulation efficiency of silibinin (96%) and a zeta potential of −26.2 ± 0.6 mV were developed and studied using nicotinamide/streptozotocin-induced diabetic rats. Administration of silibinin-loaded liposomes to diabetic rats lowered glucose levels, increased insulin levels, and improved pancreatic islet architecture. The anti-inflammatory effect of silibinin-loaded liposomes was demonstrated by a decrease in serum C-reactive protein (CRP) levels and a reduced deposition of collagen fibers in the islets of diabetic rats. Furthermore, silibinin-loaded liposomes were more efficient in lowering glucose, alanine transaminase, triglyceride, and creatinine levels in diabetic rats than pure silibinin. In addition, silibinin-loaded liposomes had a significantly better effect on beta-cell mass and Glut2 glucose receptor distribution in diabetic islets than pure silibinin. The present results clearly show that liposome encapsulation of silibinin enhances its antidiabetic efficacy, which may contribute to the therapeutic benefit of silibinin in the treatment of diabetes and its complications.
PB  - Basel: MDPI
T2  - Pharmaceutics
T1  - Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin
IS  - 6
VL  - 16
DO  - 10.3390/pharmaceutics16060801
SP  - 801
ER  - 

@article{
author = "Dinić, Svetlana and Arambašić Jovanović, Jelena and Uskoković, Aleksandra and Jovanović, Aleksandra and Grdović, Nevena and Rajić, Jovana and Đorđević, Marija and Sarić, Ana and Bugarski, Branko and Vidaković, Melita and Mihailović, Mirjana",
year = "2024",
abstract = "Silibinin has considerable therapeutic potential for the treatment of diabetes through anti-inflammatory, antioxidant, and immunomodulatory properties. However, the therapeutic application of silibinin is quite limited due to its poor bioavailability. In the present study, an attempt was made to improve the antidiabetic efficacy of silibinin by its encapsulation in liposomal vesicles. The liposomes with a high encapsulation efficiency of silibinin (96%) and a zeta potential of −26.2 ± 0.6 mV were developed and studied using nicotinamide/streptozotocin-induced diabetic rats. Administration of silibinin-loaded liposomes to diabetic rats lowered glucose levels, increased insulin levels, and improved pancreatic islet architecture. The anti-inflammatory effect of silibinin-loaded liposomes was demonstrated by a decrease in serum C-reactive protein (CRP) levels and a reduced deposition of collagen fibers in the islets of diabetic rats. Furthermore, silibinin-loaded liposomes were more efficient in lowering glucose, alanine transaminase, triglyceride, and creatinine levels in diabetic rats than pure silibinin. In addition, silibinin-loaded liposomes had a significantly better effect on beta-cell mass and Glut2 glucose receptor distribution in diabetic islets than pure silibinin. The present results clearly show that liposome encapsulation of silibinin enhances its antidiabetic efficacy, which may contribute to the therapeutic benefit of silibinin in the treatment of diabetes and its complications.",
publisher = "Basel: MDPI",
journal = "Pharmaceutics",
title = "Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin",
number = "6",
volume = "16",
doi = "10.3390/pharmaceutics16060801",
pages = "801"
}

Dinić, S., Arambašić Jovanović, J., Uskoković, A., Jovanović, A., Grdović, N., Rajić, J., Đorđević, M., Sarić, A., Bugarski, B., Vidaković, M.,& Mihailović, M.. (2024). Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin. in Pharmaceutics
Basel: MDPI., 16(6), 801.
https://doi.org/10.3390/pharmaceutics16060801

Dinić S, Arambašić Jovanović J, Uskoković A, Jovanović A, Grdović N, Rajić J, Đorđević M, Sarić A, Bugarski B, Vidaković M, Mihailović M. Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin. in Pharmaceutics. 2024;16(6):801.
doi:10.3390/pharmaceutics16060801 .

Dinić, Svetlana, Arambašić Jovanović, Jelena, Uskoković, Aleksandra, Jovanović, Aleksandra, Grdović, Nevena, Rajić, Jovana, Đorđević, Marija, Sarić, Ana, Bugarski, Branko, Vidaković, Melita, Mihailović, Mirjana, "Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin" in Pharmaceutics, 16, no. 6 (2024):801,
https://doi.org/10.3390/pharmaceutics16060801 . .

TY  - JOUR
AU  - Batinić, Petar
AU  - Jovanović, Aleksandra
AU  - Stojković, Dejan
AU  - Zengin, Gokhan
AU  - Cvijetić, Ilija
AU  - Gašić, Uroš
AU  - Čutović, Natalija
AU  - Pešić, Mirjana
AU  - Milinčić, Danijel
AU  - Carević, Tamara
AU  - Marinković, Aleksandar
AU  - Bugarski, Branko
AU  - Marković, Tatjana
PY  - 2024
UR  - http://radar.ibiss.bg.ac.rs/handle/123456789/6687
AB  - Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended for use in human therapy require specific knowledge about the chemistry of peony roots and their biological activities. In this study, ethanol–water extracts were prepared by maceration and microwave- and ultrasound-assisted extractions (MAE and UAE, respectively) in order to obtain bioactive molecules from the roots of Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L. wild growing in Serbia. Chemical characterization; polyphenol and flavonoid content; antioxidant, multianti-enzymatic, and antibacterial activities of extracts; and in vitro gastrointestinal digestion (GID) of hot water extracts were performed. The strongest anti-cholinesterase activity was observed in PT extracts. The highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical potential was observed in PP extracts, whereas against DPPH (2,2-diphenyl-1-picrylhydrazyl radicals), the best results were achieved with PO extracts. Regarding antibacterial activity, extracts were strongly potent against Bacillus cereus. A molecular docking simulation was conducted to gather insights into the binding affinity and interactions of polyphenols and other Paeonia-specific molecules in the active sites of tested enzymes. In vitro GID of Paeonia teas showed a different recovery and behavior of the individual bioactives, with an increased recovery of methyl gallate and digallate and a decreased recovery of paeoniflorin and its derivatives. PT (Gulenovci) and PP (Pirot) extracts obtained by UAE and M were more efficient in the majority of the bioactivity assays. This study represents an initial step toward the possible application of Paeonia root extracts in pharmacy, medicine, and food technologies.
PB  - Basel: MDPI
T2  - Pharmaceuticals
T1  - Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia
IS  - 4
VL  - 17
DO  - 10.3390/ph17040518
SP  - 518
ER  - 

@article{
author = "Batinić, Petar and Jovanović, Aleksandra and Stojković, Dejan and Zengin, Gokhan and Cvijetić, Ilija and Gašić, Uroš and Čutović, Natalija and Pešić, Mirjana and Milinčić, Danijel and Carević, Tamara and Marinković, Aleksandar and Bugarski, Branko and Marković, Tatjana",
year = "2024",
abstract = "Without being aware of their chemical composition, many cultures have used herbaceous peony roots for medicinal purposes. Modern phytopreparations intended for use in human therapy require specific knowledge about the chemistry of peony roots and their biological activities. In this study, ethanol–water extracts were prepared by maceration and microwave- and ultrasound-assisted extractions (MAE and UAE, respectively) in order to obtain bioactive molecules from the roots of Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L. wild growing in Serbia. Chemical characterization; polyphenol and flavonoid content; antioxidant, multianti-enzymatic, and antibacterial activities of extracts; and in vitro gastrointestinal digestion (GID) of hot water extracts were performed. The strongest anti-cholinesterase activity was observed in PT extracts. The highest anti-ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical potential was observed in PP extracts, whereas against DPPH (2,2-diphenyl-1-picrylhydrazyl radicals), the best results were achieved with PO extracts. Regarding antibacterial activity, extracts were strongly potent against Bacillus cereus. A molecular docking simulation was conducted to gather insights into the binding affinity and interactions of polyphenols and other Paeonia-specific molecules in the active sites of tested enzymes. In vitro GID of Paeonia teas showed a different recovery and behavior of the individual bioactives, with an increased recovery of methyl gallate and digallate and a decreased recovery of paeoniflorin and its derivatives. PT (Gulenovci) and PP (Pirot) extracts obtained by UAE and M were more efficient in the majority of the bioactivity assays. This study represents an initial step toward the possible application of Paeonia root extracts in pharmacy, medicine, and food technologies.",
publisher = "Basel: MDPI",
journal = "Pharmaceuticals",
title = "Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia",
number = "4",
volume = "17",
doi = "10.3390/ph17040518",
pages = "518"
}

Batinić, P., Jovanović, A., Stojković, D., Zengin, G., Cvijetić, I., Gašić, U., Čutović, N., Pešić, M., Milinčić, D., Carević, T., Marinković, A., Bugarski, B.,& Marković, T.. (2024). Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia. in Pharmaceuticals
Basel: MDPI., 17(4), 518.
https://doi.org/10.3390/ph17040518

Batinić P, Jovanović A, Stojković D, Zengin G, Cvijetić I, Gašić U, Čutović N, Pešić M, Milinčić D, Carević T, Marinković A, Bugarski B, Marković T. Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia. in Pharmaceuticals. 2024;17(4):518.
doi:10.3390/ph17040518 .

Batinić, Petar, Jovanović, Aleksandra, Stojković, Dejan, Zengin, Gokhan, Cvijetić, Ilija, Gašić, Uroš, Čutović, Natalija, Pešić, Mirjana, Milinčić, Danijel, Carević, Tamara, Marinković, Aleksandar, Bugarski, Branko, Marković, Tatjana, "Phytochemical Analysis, Biological Activities, and Molecular Docking Studies of Root Extracts from Paeonia Species in Serbia" in Pharmaceuticals, 17, no. 4 (2024):518,
https://doi.org/10.3390/ph17040518 . .