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Genistein Affects Parathyroid Gland and Napi 2a Cotransporter in An Animal Model of the Andropause
dc.creator | Živanović, Jasmina | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Jarić, Ivana | |
dc.creator | Mojić, Marija | |
dc.creator | Trifunović, Svetlana | |
dc.creator | Milošević, Verica | |
dc.creator | Filipović, Branko | |
dc.date.accessioned | 2017-11-23T11:12:15Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2013 | sr |
dc.identifier.issn | 0867-5910 | sr |
dc.identifier.other | Rad_konverzija_2995 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1000 | |
dc.description.abstract | This study aimed to examine the effects of genistein on the structural and functional changes in parathyroid glands (PTG) and sodium phosphate cotransporter 2a (NaPi 2a) in orchidectomized rats. Sixteen-month-old Wistar rats were divided into sham-operated (SO), orchidectomized (Orx) and genistein-treated orchidectomized (Orx+G) groups. Genistein (30 mg/kg/day) was administered subcutaneously for 3 weeks, while the controls received vehicle alone. PTG was analyzed histomorphometrically, while the expressions of NaPi 2a mRNA/protein levels from kidneys were determined by real time PCR and Western blots. Serum and urine parameters were determined biochemically. The PTG volume in Orx rats was increased by 30% (p<0.05), compared to the SO group. Orx+G treatment increased the PTG volume by 35% and 75% (p<0.05) respectively, comparing to Orx and SO animals. Orchidectomy led to increment of serum PTH by 27% (p<0.05) compared to the SO group, Orx+G decreased it by 18% (p<0.05) comparing to Orx animals. NaPi 2a expression in Orx animals was reduced in regards to its abundance in SO animals, although it was increased in Orx+G group compared to the Orx. Phosphorus urine content of Orx animals was raised by 12% (p<0.05) compared to that for the SO group, while Orx+G induced a 17% reduction (p<0.05) in regards to Orx animals. Our study shows that Orx increases PTG volume and serum PTH level, while protein expression of NaPi 2a is reduced. Application of genistein attenuates the orchidectomy-induced changes in serum PTH level, stimulates the expression of NaPi 2a and reduces urinary Pi excretion, implying potential beneficial effects on andropausal symptoms. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the Republic of Serbia [173009] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Journal of Physiology and Pharmacology | sr |
dc.title | Genistein Affects Parathyroid Gland and Napi 2a Cotransporter in An Animal Model of the Andropause | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Филиповић, Бранко; Медиговић, Ивана М.; Aјджановић, Владимир; Трифуновић, Светлана Л; Пантелић, Јасмина Б; Милошевић, Верица Љ.; Мојић, Марија К.; | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 64 | sr |
dc.citation.spage | 55 | sr |
dc.citation.epage | 368 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1000 |
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