Antioksidacioni efrekat koenzima Q10 u krvi pacova izlaganih kadmijumu
Antioxidant effect of coenzyme Q10 in blood from cadmium-exposed rats
2004
Authors:
Ognjanović, Branka I.Maletić, Snežana D.
Žikić, Radoslav V.
Štajn, Andraš Š.
Pavlović, Slađan
Saičić, Zorica
Document Type:
Article (Published version)
,
© 2004 Unija bioloških naučnih društava Jugoslavije
Metadata
Show full item recordAbstract:
The effects of acute exposure to cadmium (Cd) on the blood antioxidant defense system (AOS), lipid peroxide (LP) concentration and hematological parameters, and the possible protective role of coenzyme Q10 (CoQ10) was studied. Male Wistar albino rats 3 months old were treated with cadmium as CdCl2 (0,4mg Cd/kg b.m., i.p., 24h before the sacrificing) or with coenzyme Q10 + Cd (20mg CoQ10/kg b.m., i.m., 48h + 0,4 mg Cd/kg b.m., i.p., 24h before the sacrificing). The hematological parameters: red blood cells count (RBCs), hemoglobin (Hb) concentration and hematocrite (Ht) value were significantly decreased in the blood of Cd treated rats. Intoxication with Cd was also followed by significantly increased of LP concentration. We also observed increased concentrations of non-enzymatic components of antioxidant defense system (AOS): reduced glutathione (GSH), vitamin C (Vit C) and vitamin E (Vit E). Pretreatment with CoQ10 exhibited a protective role on the toxic effects of Cd on the hematological values, LP concentration as well as on endogeneous antioxidant components.
Keywords:
coenzyme Q10; koenzim Q10; cadmium; kadmijum; blood; krv; rat; pacovSource:
Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 2004, 40, 1-3, 81-88Funding / projects:
- This research was supported by the Ministry of Science, Technologies and Development of Serbia, Grant No 1669.