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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
dc.creator | McCubrey, James A | |
dc.creator | Steelman, Linda S | |
dc.creator | Chappell, William H | |
dc.creator | Abrams, Stephen L | |
dc.creator | Franklin, Richard A | |
dc.creator | Montalto, Giuseppe | |
dc.creator | Cervello, Melchiorre | |
dc.creator | Libra, Massimo | |
dc.creator | Candido, Saverio | |
dc.creator | Malaponte, Graziella | |
dc.creator | Mazzarino, Maria C | |
dc.creator | Fagone, Paolo | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Baesecke, Joerg | |
dc.creator | Mijatović, Sanja | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Milella, Michele | |
dc.creator | Tafuri, Agostino | |
dc.creator | Chiarini, Francesca | |
dc.creator | Evangelisti, Camilla | |
dc.creator | Cocco, Lucio | |
dc.creator | Martelli, Alberto M | |
dc.date.accessioned | 2017-11-23T11:12:10Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2012 | sr |
dc.identifier.issn | 1949-2553 | sr |
dc.identifier.other | Rad_konverzija_3091 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1096 | |
dc.description.abstract | The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Targeting these pathways is often complex and can result in pathway activation depending on the presence of upstream mutations (e.g., Raf inhibitors induce Raf activation in cells with wild type (WT) RAF in the presence of mutant, activated RAS) and rapamycin can induce Akt activation. Targeting with inhibitors directed at two constituents of the same pathway or two different signaling pathways may be a more effective approach. This review will first evaluate potential uses of Raf, MEK, PI3K, Akt and mTOR inhibitors that have been investigated in pre-clinical and clinical investigations and then discuss how cancers can become insensitive to various inhibitors and potential strategies to overcome this resistance. | en |
dc.description.sponsorship | Italian Ministero dellIstruzione, dellUniversita e della Ricerca (Ministry for Education, Universities and Research) - MIUR [2008THTNLC, RBAP10447J-003, RBAP11ZJFA_001]; FIRB-MERIT [RBNE08YYBM]; Italian Ministry of Economy and Finance; Italian Ministr | en |
dc.language.iso | English | sr |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Oncotarget | sr |
dc.title | Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance | en |
dc.type | review | |
dc.rights.license | BY | |
dcterms.abstract | Aбрамс, Степхен Л; Франклин, Рицхард A; Монталто, Гиусеппе; Цхиарини, Францесца; Тафури, Aгостино; Милелла, Мицхеле; Маззарино, Мариа Ц; Баесецке, Јоерг; Цоццо, Луцио; Малапонте, Гразиелла; Мијатовић, Сања A.; Евангелисти, Цамилла; Цхаппелл, Wиллиам Х; Стеелман, Линда С; Максимовић-Иванић, Данијела Д.; МцЦубреy, Јамес A; Мартелли, Aлберто М; Либра, Массимо; Цандидо, Саверио; Цервелло, Мелцхиорре; Ницолетти, Фердинандо; Фагоне, Паоло; | |
dc.rights.holder | © McCubrey et al. | |
dc.citation.issue | 10 | sr |
dc.citation.volume | 3 | sr |
dc.identifier.doi | 10.18632/oncotarget.659 | |
dc.identifier.pmid | 23085539 | |
dc.identifier.scopus | 2-s2.0-84871491627 | |
dc.identifier.wos | 000312410800009 | |
dc.citation.spage | 389 | sr |
dc.citation.epage | 1111 | sr |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/5696/659-5688-3-PB.pdf | |
dc.citation.rank | M21 |