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Oxidative stress-mediated hemolytic activity of solvent exchange-prepared fullerene (C-60) nanoparticles
dc.creator | Trpković, Andreja | |
dc.creator | Todorović-Marković, Biljana M | |
dc.creator | Kleut, Duska N | |
dc.creator | Misirkić Marjanović, Maja | |
dc.creator | Janjetović, Kristina | |
dc.creator | Vučićević, Ljubica | |
dc.creator | Pantović, Aleksandar C | |
dc.creator | Jovanović, Svetlana P | |
dc.creator | Dramicanin, Miroslav D | |
dc.creator | Marković, Zoran J | |
dc.creator | Trajković, Vladimir S | |
dc.date.accessioned | 2017-11-23T11:12:15Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2010 | sr |
dc.identifier.issn | 0957-4484 | sr |
dc.identifier.other | Rad_konverzija_3135 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1140 | |
dc.description.abstract | The present study investigated the hemolytic properties of fullerene (C-60) nanoparticles prepared by solvent exchange using tetrahydrofuran (nC(60)THF), or by mechanochemically assisted complexation with macrocyclic oligosaccharide gamma-cyclodextrin (nC(60)CDX) or the copolymer ethylene vinyl acetate-ethylene vinyl versatate (nC(60)EVA-EVV). The spectrophotometrical analysis of hemoglobin release revealed that only nC(60)THF, but not nC(60)CDX or nC(60)EVA-EVV, was able to cause lysis of human erythrocytes in a dose-and time-dependent manner. Atomic force microscopy revealed that nC(60)THF-mediated hemolysis was preceded by erythrocyte shrinkage and increase in cell surface roughness. A flow cytometric analysis confirmed a decrease in erythrocyte size and demonstrated a significant increase in reactive oxygen species production in red blood cells exposed to nC(60)THF. The nC(60)THF-triggered hemolytic activity was efficiently reduced by the antioxidants N-acetylcysteine and butylated hydroxyanisole, as well as by serum albumin, the most abundant protein in human blood plasma. These data indicate that nC(60)THF can cause serum albumin-preventable hemolysis through oxidative stress-mediated damage of the erythrocyte membrane. | en |
dc.description.sponsorship | Ministry of Science and Technological Development of the Republic of Serbia [145073] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Nanotechnology | sr |
dc.title | Oxidative stress-mediated hemolytic activity of solvent exchange-prepared fullerene (C-60) nanoparticles | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Трпковић, Aндреја; Вуцицевић, Љубица М; Драмицанин, Мирослав Д; Марковић, Зоран Ј; Клеут, Дуска Н; Мисиркић, Маја С; Јањетовић, Кристина Д.; Пантовић, Aлександар Ц; Трајковић, Владимир С; Тодоровић-Марковић, Биљана М; Јовановић, Светлана П; | |
dc.citation.issue | 37 | sr |
dc.citation.volume | 21 | sr |
dc.citation.spage | 601 | sr |
dc.citation.epage | na | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1140 |
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