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Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction
dc.creator | Oreščanin Dušić, Zorana | |
dc.creator | Miljević, Cedo D | |
dc.creator | Slavić, Marija | |
dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Blagojević, Duško | |
dc.creator | Lecić-Tosevski, Dusica M | |
dc.creator | Spasić, Mihajlo | |
dc.date.accessioned | 2017-11-23T11:12:52Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2012 | sr |
dc.identifier.issn | 0231-424X | sr |
dc.identifier.other | Rad_konverzija_3167 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1172 | |
dc.description.abstract | Tianeptine is a novel anti-depressant with an efficacy equivalent to that of classical anti-depressants. Additional beneficial effects include neuroprotection, anti-stress and anti-ulcer properties whose molecular mechanisms are still not completely understood but may involve changes in the anti-oxidant defence system. Herein, we have studied the effects of tianeptine on both contractile activity of isolated rat uteri and components of the endogenous anti-oxidative defence system. Tianeptine-induced dose-dependent inhibition of both spontaneous and Ca2+-induced contraction of uterine smooth muscle. The effect was more pronounced in the latter. Tianeptine treatment increased glutathione-peroxidase (GSH-Px) and catalase (CAT) activities in spontaneous and Ca2+-stimulated uteri. A significant decrease in glutathione-reductase (GR) activity in both spontaneous and Ca2+-induced uterine contractions after tianeptine treatment indicated a reduction in reduced glutathione and consequently a shift toward a more oxidised state in the treated uteri. In spontaneously contracting uteri, tianeptine caused a decrease in copper-zinc SOD (CuZnSOD) activity. Tianeptine's anti-depressant effects may be accomplished by triggering a cascade of cellular adaptations including inhibition of smooth muscle contractility and an adequate anti-oxidative protection response. | en |
dc.description.sponsorship | Ministry of Science and Technological Development of the Republic of Serbia, University of Belgrade [173014] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Acta Physiologica Hungarica | sr |
dc.title | Tianeptine's effects on spontaneous and Ca2+-induced uterine smooth muscle contraction | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Орешчанин-Душић, Зорана С.; Миљевић, Цедо Д; Благојевић, Душко П.; Николић-Кокић, Aлександра; Лецић-Тосевски, Дусица М; Славић, Марија; Спасић, Михајло Б.; | |
dc.citation.issue | 2 | sr |
dc.citation.volume | 99 | sr |
dc.citation.epage | 147 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1172 |
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