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Immunomodulatory actions of central ghrelin in diet-induced energy imbalance
dc.creator | Stevanović, Darko M | |
dc.creator | Starčević, Vesna P. | |
dc.creator | Vilimanović, Uros | |
dc.creator | Nesić, Dejan M | |
dc.creator | Vučićević, Ljubica | |
dc.creator | Misirkić Marjanović, Maja | |
dc.creator | Janjetović, Kristina | |
dc.creator | Savić, Emina | |
dc.creator | Popadić, Dusan M | |
dc.creator | Sudar, Emina M | |
dc.creator | Micić, Dragan D | |
dc.creator | Sumarac-Dumanović, Mirjana S | |
dc.creator | Trajković, Vladimir S | |
dc.date.accessioned | 2017-11-23T11:08:08Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2012 | sr |
dc.identifier.issn | 0889-1591 | sr |
dc.identifier.other | Rad_konverzija_3233 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1238 | |
dc.description.abstract | We investigated the effects of centrally administered orexigenic hormone ghrelin on energy imbalance-induced inflammation. Rats were subjected for four weeks to three different dietary regimes: normal (standard food), high-fat (standard food with 30% lard) or food-restricted (70%, 50%, 40% and 40% of the expected food intake in 1st, 2nd, 3rd and 4th week, respectively). Compared to normal-weight controls, starved, but not obese rats had significantly higher levels of proinflammatory cytokines (TNF, IL-1 beta, IFN-gamma) in the blood. When compared to normally fed animals, the hearts of starved and obese animals expressed higher levels of mRNAs encoding proinflammatory mediators (TNF, IL-1 beta, IL-6, IFN-gamma, IL-17, IL-12, iNOS), while mRNA levels of the anti-inflammatory TGF-beta remained unchanged. Intracerebroventricular (ICV) injection of ghrelin (1 mu g/day) for five consecutive days significantly reduced TNF, IL-1 beta and IFN-gamma levels in the blood of starved rats, as well as TNF, IL-17 and IL-12p40 mRNA expression in the hearts of obese rats. Conversely, ICV ghrelin increased the levels of 1FN-gamma, IL-17,1L-12p35 and IL-12p40 mRNA in the heart tissue of food-restricted animals. This was associated with an increase of immunosuppressive ACTH/corticosterone production in starved animals and a decrease of the immunostimulatory adipokine leptin both in food-restricted and high-fat groups. Ghrelin activated the energy sensor AMP-activated protein kinase (AMPK) in the hypothalamus and inhibited extracellular signal-regulated kinase (ERK) in the hearts of obese, but not starved rats. Therefore, central ghrelin may play a complex role in energy imbalance-induced inflammation by modulating HPA axis, leptin and AMPK/ERK signaling pathways. (C) 2011 Elsevier Inc. All rights reserved. | en |
dc.description.sponsorship | Ministry of Science and Technological Development of the Republic of Serbia [41025, 175067] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | Brain Behavior and Immunity | sr |
dc.title | Immunomodulatory actions of central ghrelin in diet-induced energy imbalance | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Сумарац-Думановић, Мирјана С; Мицић, Драган Д; Вуцицевић, Љубица М; Судар, Емина М; Стевановић, Дарко М; Старчевић, Весна П.; Попадић, Дусан М; Трајковић, Владимир С; Несић, Дејан М; Савић, Емина; Вилимановић, Урос; Мисиркић, Маја С; Јањетовић, Кристина Д.; | |
dc.citation.issue | 1 | sr |
dc.citation.volume | 26 | sr |
dc.citation.epage | 158 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1238 |
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