The Demise of the Blood-Brain Barrier in Amyotrophic Lateral Sclerosis and the Role of Astrocytes
2011
Аутори:
Bataveljić, Danijela BKorenić, Andrej
Nikolić, Ljiljana
Todorović, Nataša
Moghaddam-Amiry, M
Anđus, Pavle R
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2011 Wiley‐Liss, Inc.
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Combined MRI and immunofluorescence studies on the brain of the transgenic hSOD1 G93A ALS rat model reveled astrogliosis near dilated lateral ventricles and blood-brain barrier (BBB) compromise. It was thus of particular interest to check the expression of glial aquaporins known to be specifically present in the astroglial endfeet of the BBB. Immunoflu-orescence revealed a more abundant expression of aquaporin 4 (AQP4) in the brainstem and cerebral cortex of ALS rats. Immunogold EM studies
also revealed a supramolecular change in the distribution of AQP4 in
astrocytic endfeet ensheathing blood vessels. A reverse expression was also observed for astrocytic AQP4 versus the Kir 4.1 channel-the two proteins known to form aggregates. Preliminary electrophysiological data on astrocytes in culture showed a different behavior of the Kir current as compared to the wild type. Thus, a role of glia in the demise of the BBB in the ALS brain was suggested with the AQP4 and Kir4. 1 complex being the molecular target for possible therapies.
У:
- 10th European meeting on Glial Cells in Health and Disease; 2011 Sep 13-17; Prague, Czech Republic. John Wiley and Sons; 2011. p. S83. (Glia; Vol 59; Suppl. 1).