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The effect of chronic food restriction on immunopositive ACTH cells in peripubertal female rats
dc.creator | Milošević, Verica | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Bogojević, Desanka | |
dc.creator | Jarić, Ivana | |
dc.creator | Ivanović Matić, Svetlana | |
dc.creator | Martinović, Vesna | |
dc.creator | Grigorov, Ilijana | |
dc.date.accessioned | 2017-11-23T11:08:17Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2011 | sr |
dc.identifier.issn | 0231-5882 | sr |
dc.identifier.other | Rad_konverzija_3261 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1266 | |
dc.description.abstract | In peripubertal female rats, we have previously found that 50% food restriction (FR) increases plasma IL-6, haptoglobin and both alanine transaminase (ALT) and alkaline phosphatase (AST) aminotransferases, indicating the existence of an inflammatory response. To study whether such FR influences the hypothalamic-pituitary-adrenal (HPA) axis, we examined by immunohistochemistry the morphofunctional features of pituitary adrenocorticotropic (ACTH) cells. In FR rats the volume and volume density of ACTH cells as well as plasma ACTH levels were increased by 17.6%, 12.5% and 13.4%, respectively, in comparison with controls (p < 0.05). We concluded that chronic FR is a systemic stressor in young females, capable to stimulate the HPA axis, probably as a result of IL-6 action. | en |
dc.description.sponsorship | Ministry for Education and Science of Republic of Serbia [173009, 173020] | sr |
dc.language.iso | English | sr |
dc.rights | restrictedAccess | |
dc.source | General Physiology and Biophysics | sr |
dc.title | The effect of chronic food restriction on immunopositive ACTH cells in peripubertal female rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Богојевић, Десанка Б.; Медиговић, Ивана М.; Aјджановић, Владимир; Григоров, Илијана И.; Мартиновић, Весна И; Ивановић-Матић, Светлана К.; Милошевић, Верица Љ.; | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 30 | sr |
dc.citation.epage | 324 | sr |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_1266 |
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