Terapijski efekat nukleozidnih analoga na eksperimentalni autoimunski encefalomijelitis kod dark agouti pacova
Therapeutic effect of nucleoside analogs on experimental autoimmune encephalomyelitis in dark agouti rats
Authors:
Savić, DanijelaLavrnja, Irena
Šubašić, Sanja
Bjelobaba, Ivana
Peković, Sanja
Gađanski, Ivana
Mostarica-Stojković, Marija B
Stošić-Grujičić, Stanislava
Rakić, Lj.
Stojiljković, Mirjana
Document Type:
Article (Published version)
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Show full item recordAbstract:
Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model of the human neurological disorder multiple sclerosis. The purpose of the present study was to investigate the effect of combined treatment with two nucleoside analogs, ribavirin and tiazofurin, on development of EAE actively induced in highly susceptible dark agouti rats. The obtained results showed that ribavirin and tiazofurin applied either separately or in combination from the onset of the firstsymptoms of EAE after its induction (therapeutic treatment) significantly suppressed EAE’s clinical symptoms. However, the most pronounced effect was gained with combined treatment, probably as a result of synergistic/additive action.