Terapijski efekat nukleozidnih analoga na eksperimentalni autoimunski encefalomijelitis kod dark agouti pacova

Abstract

Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model of the human neurological disorder multiple sclerosis. The purpose of the present study was to investigate the effect of combined treatment with two nucleoside analogs, ribavirin and tiazofurin, on development of EAE actively induced in highly susceptible dark agouti rats. The obtained results showed that ribavirin and tiazofurin applied either separately or in combination from the onset of the firstsymptoms of EAE after its induction (therapeutic treatment) significantly suppressed EAE’s clinical symptoms. However, the most pronounced effect was gained with combined treatment, probably as a result of synergistic/additive action.

Eksperimentalni autoimunski encefalomijelitis (EAE) je animalni model koji se obično koristi kao prototip humanog neurološkog oboljenja - multiple skleroze. Cilj ove studije bio je ispitivanje efekta kombinovane terapije sa dva nukleozidna analoga, ribavirina i tiazofurina, na razvoj EAE, aktivno izazvanog kod veoma osetljivog dark aguti soja pacova. Dobijeni rezultati pokazali su da ribavirin i tiazofurin, primenjeni pojedinačno ili u kombinaciji, od pojave prvog simptoma EAE (terapijski tretman), značajno suprimiraju težinu ove bolesti. Međutim, najbolji efekti su postignuti kombinovanim tretmanom, što je verovatno posledica sinergističkog ili aditivnog delovanja ribavirina i tiazofurina.