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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
dc.creator | Chappell, William H | |
dc.creator | Steelman, Linda S | |
dc.creator | Long, Jacquelyn M | |
dc.creator | Kempf, Ruth C | |
dc.creator | Abrams, Stephen L | |
dc.creator | Franklin, Richard A | |
dc.creator | Baesecke, Joerg | |
dc.creator | Stivala, Franca | |
dc.creator | Donia, Marco | |
dc.creator | Fagone, Paolo | |
dc.creator | Malaponte, Graziella | |
dc.creator | Mazzarino, Maria C | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Libra, Massimo | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mijatović, Sanja | |
dc.creator | Montalto, Giuseppe | |
dc.creator | Cervello, Melchiorre | |
dc.creator | Laidler, Piotr | |
dc.creator | Milella, Michele | |
dc.creator | Tafuri, Agostino | |
dc.creator | Bonati, Antonio | |
dc.creator | Evangelisti, Camilla | |
dc.creator | Cocco, Lucio | |
dc.creator | Martelli, Alberto M | |
dc.creator | McCubrey, James A | |
dc.date.accessioned | 2017-11-23T11:08:37Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2011 | sr |
dc.identifier.issn | 1949-2553 | sr |
dc.identifier.other | Rad_konverzija_3295 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1300 | |
dc.description.abstract | The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, PI3K, and PTEN are also activated/inactivated by mutations. These pathways have profound effects on proliferative, apoptotic and differentiation pathways. Dysregulation of these pathways can contribute to chemotherapeutic drug resistance, proliferation of cancer initiating cells (CICs) and premature aging. This review will evaluate more recently described potential uses of MEK, PI3K, Akt and mTOR inhibitors in the proliferation of malignant cells, suppression of CICs, cellular senescence and prevention of aging. Ras/Raf/MEK/ERK and Ras/PI3K/PTEN/Akt/mTOR pathways play key roles in the regulation of normal and malignant cell growth. Inhibitors targeting these pathways have many potential uses from suppression of cancer, proliferative diseases as well as aging. | en |
dc.description.sponsorship | Fondazione del Monte di Bologna e Ravenna [IGF-1, RBAP10447J] | sr |
dc.language.iso | English | sr |
dc.relation | Fondazione del Monte di Bologna e Ravenna (IGF-1 RBAP10447J) | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Oncotarget | sr |
dc.title | Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health | en |
dc.type | review | |
dc.rights.license | BY | |
dcterms.abstract | МцЦубреy, Јамес A; Фагоне, Паоло; Дониа, Марцо; Стеелман, Линда С; Стивала, Франца; Максимовић-Иванић, Данијела Д.; Баесецке, Јоерг; Франклин, Рицхард A; Aбрамс, Степхен Л; Кемпф, Рутх Ц; Лонг, Јацqуелyн М; Монталто, Гиусеппе; Лаидлер, Пиотр; Милелла, Мицхеле; Тафури, Aгостино; Бонати, Aнтонио; Евангелисти, Цамилла; Цоццо, Луцио; Мартелли, Aлберто М; Мијатовић, Сања A.; Цхаппелл, Wиллиам Х; Малапонте, Гразиелла; Маззарино, Мариа Ц; Ницолетти, Фердинандо; Либра, Массимо; Цервелло, Мелцхиорре; | |
dc.rights.holder | © Chappell et al. | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 2 | sr |
dc.identifier.doi | 10.18632/oncotarget.240 | |
dc.identifier.pmid | 21411864 | |
dc.identifier.scopus | 2-s2.0-79959712087 | |
dc.identifier.wos | 000293509000007 | |
dc.citation.epage | 164 | sr |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/5689/240-1225-4-PB.pdf | |
dc.citation.rank | M21 | |
dc.citation.rank | M21 |