Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
2011
Аутори:
Steelman, Linda SChappell, William H
Abrams, Stephen L
Kempf, C Ruth
Long, Jacquelyn M
Laidler, Piotr
Mijatović, Sanja
Maksimović-Ivanić, Danijela
Stivala, Franca
Mazzarino, Maria C
Donia, Marco
Fagone, Paolo
Malaponte, Graziella
Nicoletti, Ferdinando
Libra, Massimo
Milella, Michele
Tafuri, Agostino
Bonati, Antonio
Baesecke, Joerg
Cocco, Lucio
Evangelisti, Camilla
Martelli, Alberto M
Montalto, Giuseppe
Cervello, Melchiorre
McCubrey, James A
Тип документа:
Приказ (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.
Кључне речи:
Raf; MEK; PI3K; mTOR; cancer; kinases; protein phosphorylation; signal transduction; apoptosisИзвор:
Aging-US, 2011, 3, 3, -222Финансирање / пројекти:
- Fondazione del Monte di Bologna e Ravenna (RBAP10447J)
DOI: 10.18632/aging.100296
ISSN: 1945-4589
PubMed: 21422497