dc.creator | Steelman, Linda S | |
dc.creator | Chappell, William H | |
dc.creator | Abrams, Stephen L | |
dc.creator | Kempf, C Ruth | |
dc.creator | Long, Jacquelyn M | |
dc.creator | Laidler, Piotr | |
dc.creator | Mijatović, Sanja | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Stivala, Franca | |
dc.creator | Mazzarino, Maria C | |
dc.creator | Donia, Marco | |
dc.creator | Fagone, Paolo | |
dc.creator | Malaponte, Graziella | |
dc.creator | Nicoletti, Ferdinando | |
dc.creator | Libra, Massimo | |
dc.creator | Milella, Michele | |
dc.creator | Tafuri, Agostino | |
dc.creator | Bonati, Antonio | |
dc.creator | Baesecke, Joerg | |
dc.creator | Cocco, Lucio | |
dc.creator | Evangelisti, Camilla | |
dc.creator | Martelli, Alberto M | |
dc.creator | Montalto, Giuseppe | |
dc.creator | Cervello, Melchiorre | |
dc.creator | McCubrey, James A | |
dc.date.accessioned | 2017-11-23T11:08:37Z | |
dc.date.available | 2015-11-17T10:26:51Z | |
dc.date.issued | 2011 | sr |
dc.identifier.issn | 1945-4589 | sr |
dc.identifier.other | Rad_konverzija_3297 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/1302 | |
dc.identifier.uri | https://www.aging-us.com/article/100296 | |
dc.description.abstract | Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health. | en |
dc.description.sponsorship | Fondazione del Monte di Bologna e Ravenna [RBAP10447J] | sr |
dc.language.iso | English | sr |
dc.relation | Fondazione del Monte di Bologna e Ravenna
(RBAP10447J) | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Aging-US | sr |
dc.subject | Raf | |
dc.subject | MEK | |
dc.subject | PI3K | |
dc.subject | mTOR | |
dc.subject | cancer | |
dc.subject | kinases | |
dc.subject | protein phosphorylation | |
dc.subject | signal transduction | |
dc.subject | apoptosis | |
dc.title | Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging | en |
dc.type | review | |
dc.rights.license | BY | |
dcterms.abstract | Евангелисти, Цамилла; Цхаппелл, Wиллиам Х; Стеелман, Линда С; Aбрамс, Степхен Л; Кемпф, Ц Рутх; Лонг, Јацqуелyн М; Лаидлер, Пиотр; Стивала, Франца; Маззарино, Мариа Ц; Дониа, Марцо; Фагоне, Паоло; Малапонте, Гразиелла; Ницолетти, Фердинандо; Либра, Массимо; Милелла, Мицхеле; Тафури, Aгостино; Бонати, Aнтонио; Баесецке, Јоерг; Цоццо, Луцио; Мартелли, Aлберто М; Монталто, Гиусеппе; Цервелло, Мелцхиорре; МцЦубреy, Јамес A; Мијатовић, Сања A.; Максимовић-Иванић, Данијела Д.; | |
dc.rights.holder | © Steelman et al. | |
dc.citation.issue | 3 | sr |
dc.citation.volume | 3 | sr |
dc.identifier.doi | 10.18632/aging.100296 | |
dc.identifier.pmid | 21422497 | |
dc.identifier.scopus | 2-s2.0-79961173138 | |
dc.identifier.wos | 000289311900007 | |
dc.citation.epage | 222 | sr |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/5688/98FYyd8vrZaFXQbTX.pdf | |
dc.citation.rank | M21 | |
dc.citation.rank | aM21 | |